CATH Superfamily 1.20.1250.10
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 24: Interleukin-23 subunit alpha
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 1 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | Q9EQ14 (/IPI) Q9NPF7 (/IPI) Q9NPF7 (/IPI) Q9NPF7 (/IPI) |
There are 62 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
|
4 | Q9EQ14 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) |
|
Positive regulation of T-helper 1 type immune response GO:0002827
Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response.
|
4 | Q9EQ14 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) |
|
Positive regulation of T cell mediated cytotoxicity GO:0001916
Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.
|
3 | Q9NPF7 (/ISS) Q9NPF7 (/ISS) Q9NPF7 (/ISS) |
|
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
|
3 | Q9NPF7 (/ISS) Q9NPF7 (/ISS) Q9NPF7 (/ISS) |
|
Positive regulation of T-helper 1 type immune response GO:0002827
Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response.
|
3 | Q9NPF7 (/ISS) Q9NPF7 (/ISS) Q9NPF7 (/ISS) |
|
Positive regulation of T-helper 1 type immune response GO:0002827
Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response.
|
3 | Q9NPF7 (/NAS) Q9NPF7 (/NAS) Q9NPF7 (/NAS) |
|
Positive regulation of T-helper 1 type immune response GO:0002827
Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response.
|
3 | Q9NPF7 (/TAS) Q9NPF7 (/TAS) Q9NPF7 (/TAS) |
|
Positive regulation of activation of Janus kinase activity GO:0010536
Any process that increases the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.
|
3 | Q9NPF7 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) |
|
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | Q9NPF7 (/TAS) Q9NPF7 (/TAS) Q9NPF7 (/TAS) |
|
Negative regulation of interleukin-10 production GO:0032693
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.
|
3 | Q9NPF7 (/IMP) Q9NPF7 (/IMP) Q9NPF7 (/IMP) |
|
Positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725
Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.
|
3 | Q9NPF7 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) |
|
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
|
3 | Q9NPF7 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) |
|
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
|
3 | Q9NPF7 (/TAS) Q9NPF7 (/TAS) Q9NPF7 (/TAS) |
|
Positive regulation of interleukin-10 production GO:0032733
Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
|
3 | Q9NPF7 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) |
|
Positive regulation of interleukin-10 production GO:0032733
Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
|
3 | Q9NPF7 (/TAS) Q9NPF7 (/TAS) Q9NPF7 (/TAS) |
|
Positive regulation of interleukin-12 production GO:0032735
Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
|
3 | Q9NPF7 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) |
|
Positive regulation of interleukin-17 production GO:0032740
Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
|
3 | Q9NPF7 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) |
|
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
|
3 | Q9NPF7 (/IMP) Q9NPF7 (/IMP) Q9NPF7 (/IMP) |
|
Positive regulation of natural killer cell activation GO:0032816
Any process that activates or increases the frequency, rate or extent of natural killer cell activation.
|
3 | Q9NPF7 (/IC) Q9NPF7 (/IC) Q9NPF7 (/IC) |
|
Positive regulation of natural killer cell proliferation GO:0032819
Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation.
|
3 | Q9NPF7 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) |
|
Positive regulation of tissue remodeling GO:0034105
Any process that activates or increases the frequency, rate, or extent of tissue remodeling.
|
3 | Q9NPF7 (/IC) Q9NPF7 (/IC) Q9NPF7 (/IC) |
|
Interleukin-23-mediated signaling pathway GO:0038155
A series of molecular signals initiated by the binding of interleukin-23 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | Q9NPF7 (/TAS) Q9NPF7 (/TAS) Q9NPF7 (/TAS) |
|
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
|
3 | Q9NPF7 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) |
|
Positive regulation of activated T cell proliferation GO:0042104
Any process that activates or increases the rate or extent of activated T cell proliferation.
|
3 | Q9NPF7 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) |
|
Regulation of tyrosine phosphorylation of STAT protein GO:0042509
Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
3 | Q9NPF7 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) |
|
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
3 | Q9NPF7 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) |
|
Positive regulation of memory T cell differentiation GO:0043382
Any process that activates or increases the frequency, rate or extent of memory T cell differentiation.
|
3 | Q9NPF7 (/ISS) Q9NPF7 (/ISS) Q9NPF7 (/ISS) |
|
Positive regulation of osteoclast differentiation GO:0045672
Any process that activates or increases the frequency, rate or extent of osteoclast differentiation.
|
3 | Q9NPF7 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) |
|
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
|
3 | Q9NPF7 (/IC) Q9NPF7 (/IC) Q9NPF7 (/IC) |
|
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
|
3 | Q9NPF7 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) |
|
Positive regulation of NK T cell activation GO:0051135
Any process that activates or increases the frequency, rate or extent of natural killer T cell activation.
|
3 | Q9NPF7 (/IC) Q9NPF7 (/IC) Q9NPF7 (/IC) |
|
Positive regulation of NK T cell activation GO:0051135
Any process that activates or increases the frequency, rate or extent of natural killer T cell activation.
|
3 | Q9NPF7 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) |
|
Positive regulation of NK T cell proliferation GO:0051142
Any process that activates or increases the frequency, rate or extent of natural killer T cell proliferation.
|
3 | Q9NPF7 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) |
|
Positive regulation of NIK/NF-kappaB signaling GO:1901224
Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
|
3 | Q9NPF7 (/TAS) Q9NPF7 (/TAS) Q9NPF7 (/TAS) |
|
Positive regulation of T-helper 17 type immune response GO:2000318
Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response.
|
3 | Q9NPF7 (/ISS) Q9NPF7 (/ISS) Q9NPF7 (/ISS) |
|
Positive regulation of T-helper 17 cell lineage commitment GO:2000330
Any process that activates or increases the frequency, rate or extent of T-helper 17 cell lineage commitment.
|
3 | Q9NPF7 (/ISS) Q9NPF7 (/ISS) Q9NPF7 (/ISS) |
|
Positive regulation of T cell mediated cytotoxicity GO:0001916
Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.
|
1 | Q9EQ14 (/IDA) |
|
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
|
1 | Q9EQ14 (/ISO) |
|
Positive regulation of T-helper 1 type immune response GO:0002827
Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response.
|
1 | Q9EQ14 (/ISO) |
|
Positive regulation of activation of Janus kinase activity GO:0010536
Any process that increases the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.
|
1 | Q9EQ14 (/ISO) |
|
Negative regulation of interleukin-10 production GO:0032693
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.
|
1 | Q9EQ14 (/ISO) |
|
Positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725
Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.
|
1 | Q9EQ14 (/ISO) |
|
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
|
1 | Q9EQ14 (/ISO) |
|
Positive regulation of interleukin-10 production GO:0032733
Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
|
1 | Q9EQ14 (/ISO) |
|
Positive regulation of interleukin-12 production GO:0032735
Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
|
1 | Q9EQ14 (/ISO) |
|
Positive regulation of interleukin-17 production GO:0032740
Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.
|
1 | Q9EQ14 (/ISO) |
|
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
|
1 | Q9EQ14 (/ISO) |
|
Positive regulation of natural killer cell proliferation GO:0032819
Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation.
|
1 | Q9EQ14 (/ISO) |
|
T cell proliferation GO:0042098
The expansion of a T cell population by cell division. Follows T cell activation.
|
1 | Q9EQ14 (/IDA) |
|
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
|
1 | Q9EQ14 (/ISO) |
|
Positive regulation of activated T cell proliferation GO:0042104
Any process that activates or increases the rate or extent of activated T cell proliferation.
|
1 | Q9EQ14 (/ISO) |
|
Regulation of tyrosine phosphorylation of STAT protein GO:0042509
Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
1 | Q9EQ14 (/ISO) |
|
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
1 | Q9EQ14 (/ISO) |
|
Positive regulation of memory T cell differentiation GO:0043382
Any process that activates or increases the frequency, rate or extent of memory T cell differentiation.
|
1 | Q9EQ14 (/IDA) |
|
Positive regulation of osteoclast differentiation GO:0045672
Any process that activates or increases the frequency, rate or extent of osteoclast differentiation.
|
1 | Q9EQ14 (/ISO) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q9EQ14 (/IGI) |
|
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
|
1 | Q9EQ14 (/ISO) |
|
Positive regulation of NK T cell activation GO:0051135
Any process that activates or increases the frequency, rate or extent of natural killer T cell activation.
|
1 | Q9EQ14 (/ISO) |
|
Positive regulation of NK T cell proliferation GO:0051142
Any process that activates or increases the frequency, rate or extent of natural killer T cell proliferation.
|
1 | Q9EQ14 (/ISO) |
|
Positive regulation of neutrophil chemotaxis GO:0090023
Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
|
1 | Q9EQ14 (/IDA) |
|
Positive regulation of T-helper 17 type immune response GO:2000318
Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response.
|
1 | Q9EQ14 (/IDA) |
|
Positive regulation of T-helper 17 cell lineage commitment GO:2000330
Any process that activates or increases the frequency, rate or extent of T-helper 17 cell lineage commitment.
|
1 | Q9EQ14 (/IDA) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
4 | Q9EQ14 (/TAS) Q9NPF7 (/TAS) Q9NPF7 (/TAS) Q9NPF7 (/TAS) |
|
Interleukin-23 complex GO:0070743
A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space.
|
4 | Q9EQ14 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) Q9NPF7 (/IDA) |
|
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
|
3 | Q9NPF7 (/TAS) Q9NPF7 (/TAS) Q9NPF7 (/TAS) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q9EQ14 (/IDA) |
|
Interleukin-23 complex GO:0070743
A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space.
|
1 | Q9EQ14 (/ISO) |