The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glycerol uptake facilitator protein.
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 29: Aquaporin NIP1-1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Arsenite transmembrane transporter activity GO:0015105
Enables the transfer of arsenite from one side of a membrane to the other.
4 Q8LFP7 (/IDA) Q8VZW1 (/IDA) Q8VZW1 (/IDA) Q8VZW1 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q8VZW1 (/IPI) Q8VZW1 (/IPI) Q8VZW1 (/IPI)
Water channel activity GO:0015250
Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
3 Q8VZW1 (/IDA) Q8VZW1 (/IDA) Q8VZW1 (/IDA)
Lactate transmembrane transporter activity GO:0015129
Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.
2 Q8W037 (/IDA) Q8W037 (/IDA)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Arsenite transport GO:0015700
The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 Q8LFP7 (/IDA) Q8VZW1 (/IDA) Q8VZW1 (/IDA) Q8VZW1 (/IDA)
Response to arsenic-containing substance GO:0046685
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
4 Q8LFP7 (/IMP) Q8VZW1 (/IMP) Q8VZW1 (/IMP) Q8VZW1 (/IMP)
Hydrogen peroxide transmembrane transport GO:0080170
The process in which hydrogen peroxide is transported across a membrane.
4 Q8LFP7 (/IDA) Q8VZW1 (/IDA) Q8VZW1 (/IDA) Q8VZW1 (/IDA)
Water transport GO:0006833
The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 Q9ATN4 (/RCA) Q9ATN4 (/RCA) Q9LKJ5 (/RCA)
Glycerol transport GO:0015793
The directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
3 Q9ATN4 (/RCA) Q9ATN4 (/RCA) Q9LKJ5 (/RCA)
Regulation of defense response GO:0031347
Any process that modulates the frequency, rate or extent of a defense response.
3 Q8VZW1 (/IMP) Q8VZW1 (/IMP) Q8VZW1 (/IMP)
Hydrogen peroxide transmembrane transport GO:0080170
The process in which hydrogen peroxide is transported across a membrane.
3 Q8VZW1 (/IMP) Q8VZW1 (/IMP) Q8VZW1 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 Q8W037 (/IEP) Q8W037 (/IEP)
Lactate transport GO:0015727
The directed movement of lactate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.
2 Q8W037 (/IDA) Q8W037 (/IDA)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 Q8LFP7 (/IDA) Q8VZW1 (/IDA) Q8VZW1 (/IDA) Q8VZW1 (/IDA) Q8W037 (/IDA) Q8W037 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 Q9ATN4 (/TAS) Q9ATN4 (/TAS) Q9LKJ5 (/TAS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
2 Q8W037 (/IDA) Q8W037 (/IDA)