The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: Olfactory receptor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Olfactory receptor activity GO:0004984
Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.
113 A0A0N4SVP2 (/ISA) A0A1L1SQF6 (/ISA) A0A1L1SSB4 (/ISA) A0A2I3BRQ0 (/ISA) A0A2I3BRV8 (/ISA) A0AUK6 (/ISA) A1L1B1 (/ISA) A1L3R5 (/ISA) A1L3R8 (/ISA) A2ACY7 (/ISA)
(103 more)
Olfactory receptor activity GO:0004984
Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.
4 P58181 (/NAS) P58181 (/NAS) Q96R27 (/NAS) Q96R27 (/NAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q8N349 (/IPI) Q8N349 (/IPI) Q9H205 (/IPI) Q9H205 (/IPI)
Olfactory receptor activity GO:0004984
Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.
2 P34984 (/ISO) P34984 (/ISO)
Olfactory receptor activity GO:0004984
Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.
1 G3V922 (/ISS)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
113 A0A0N4SVP2 (/ISA) A0A1L1SQF6 (/ISA) A0A1L1SSB4 (/ISA) A0A2I3BRQ0 (/ISA) A0A2I3BRV8 (/ISA) A0AUK6 (/ISA) A1L1B1 (/ISA) A1L3R5 (/ISA) A1L3R8 (/ISA) A2ACY7 (/ISA)
(103 more)
Sensory perception of smell GO:0007608
The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
113 A0A0N4SVP2 (/ISA) A0A1L1SQF6 (/ISA) A0A1L1SSB4 (/ISA) A0A2I3BRQ0 (/ISA) A0A2I3BRV8 (/ISA) A0AUK6 (/ISA) A1L1B1 (/ISA) A1L3R5 (/ISA) A1L3R8 (/ISA) A2ACY7 (/ISA)
(103 more)
Sensory perception of smell GO:0007608
The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
4 P58181 (/NAS) P58181 (/NAS) Q96R27 (/NAS) Q96R27 (/NAS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P34984 (/ISO) P34984 (/ISO)
Sensory perception of smell GO:0007608
The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
2 P34984 (/ISO) P34984 (/ISO)
Positive regulation of cytokinesis GO:0032467
Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
2 O95047 (/IMP) O95047 (/IMP)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
2 O95047 (/IMP) O95047 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
113 A0A0N4SVP2 (/ISA) A0A1L1SQF6 (/ISA) A0A1L1SSB4 (/ISA) A0A2I3BRQ0 (/ISA) A0A2I3BRV8 (/ISA) A0AUK6 (/ISA) A1L1B1 (/ISA) A1L3R5 (/ISA) A1L3R8 (/ISA) A2ACY7 (/ISA)
(103 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
67 A3KFT3 (/TAS) A4D2G3 (/TAS) A4D2G3 (/TAS) A6NH00 (/TAS) A6NM03 (/TAS) A6NM03 (/TAS) O43869 (/TAS) O43869 (/TAS) O95047 (/TAS) O95047 (/TAS)
(57 more)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P34984 (/ISO) P34984 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q96R27 (/NAS) Q96R27 (/NAS)
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
2 O95047 (/IDA) O95047 (/IDA)
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
2 P34984 (/ISO) P34984 (/ISO)
Recycling endosome GO:0055037
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
2 O95047 (/IDA) O95047 (/IDA)
Recycling endosome GO:0055037
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
2 P34984 (/ISO) P34984 (/ISO)
Flemming body GO:0090543
A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge.
2 O95047 (/IDA) O95047 (/IDA)
Flemming body GO:0090543
A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge.
2 P34984 (/ISO) P34984 (/ISO)
Mitotic spindle pole GO:0097431
Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
2 O95047 (/IDA) O95047 (/IDA)
Mitotic spindle pole GO:0097431
Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
2 P34984 (/ISO) P34984 (/ISO)
Mitotic spindle midzone GO:1990023
The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner.
2 O95047 (/IDA) O95047 (/IDA)
Mitotic spindle midzone GO:1990023
The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner.
2 P34984 (/ISO) P34984 (/ISO)