The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 77: Melanocortin receptor 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 18 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
11 P32245 (/IPI) P32245 (/IPI) P32245 (/IPI) P33032 (/IPI) P33032 (/IPI) P33033 (/IPI) P33033 (/IPI) P41968 (/IPI) P56450 (/IPI) P56450 (/IPI)
(1 more)
Melanocyte-stimulating hormone receptor activity GO:0004980
Combining with melanocyte-stimulating hormone to initiate a change in cell activity.
7 P32245 (/IDA) P32245 (/IDA) P32245 (/IDA) P33033 (/IDA) P33033 (/IDA) P56450 (/IDA) P56450 (/IDA)
Melanocortin receptor activity GO:0004977
Combining with melanocortin to initiate a change in cell activity.
6 B0V1P1 (/IDA) P32244 (/IDA) P35345 (/IDA) P56450 (/IDA) P56450 (/IDA) P70596 (/IDA)
Melanocortin receptor activity GO:0004977
Combining with melanocortin to initiate a change in cell activity.
6 P32245 (/TAS) P32245 (/TAS) P32245 (/TAS) P33032 (/TAS) P33032 (/TAS) P41968 (/TAS)
Melanocortin receptor activity GO:0004977
Combining with melanocortin to initiate a change in cell activity.
5 P33033 (/ISO) P33033 (/ISO) P41149 (/ISO) P56450 (/ISO) P56450 (/ISO)
Melanocyte-stimulating hormone receptor activity GO:0004980
Combining with melanocyte-stimulating hormone to initiate a change in cell activity.
4 P32245 (/IPI) P32245 (/IPI) P32245 (/IPI) P41968 (/IPI)
Melanocyte-stimulating hormone receptor activity GO:0004980
Combining with melanocyte-stimulating hormone to initiate a change in cell activity.
4 P33033 (/ISO) P33033 (/ISO) P56450 (/ISO) P56450 (/ISO)
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
4 P33033 (/ISO) P33033 (/ISO) P56450 (/ISO) P56450 (/ISO)
Neuropeptide binding GO:0042923
Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators).
4 P32245 (/IMP) P32245 (/IMP) P32245 (/IMP) P41968 (/IMP)
Neuropeptide binding GO:0042923
Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators).
4 P33033 (/ISO) P33033 (/ISO) P56450 (/ISO) P56450 (/ISO)
Melanocortin receptor activity GO:0004977
Combining with melanocortin to initiate a change in cell activity.
3 P32244 (/IMP) P35345 (/IMP) P70596 (/IMP)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
3 P32245 (/IPI) P32245 (/IPI) P32245 (/IPI)
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
3 P41149 (/ISO) P56450 (/ISO) P56450 (/ISO)
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
2 P32244 (/IDA) P70596 (/IDA)
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
2 P32244 (/IMP) P70596 (/IMP)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
2 P56450 (/ISO) P56450 (/ISO)
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
2 P35345 (/IDA) P70596 (/IDA)
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
1 P35345 (/IMP)

There are 41 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
7 B0V1P1 (/IDA) P32245 (/IDA) P32245 (/IDA) P32245 (/IDA) P33032 (/IDA) P33032 (/IDA) P41968 (/IDA)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
6 P32245 (/TAS) P32245 (/TAS) P32245 (/TAS) P33032 (/TAS) P33032 (/TAS) P41968 (/TAS)
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
5 P33033 (/ISO) P33033 (/ISO) P41149 (/ISO) P56450 (/ISO) P56450 (/ISO)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
5 P32245 (/IMP) P32245 (/IMP) P32245 (/IMP) P56450 (/IMP) P56450 (/IMP)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.
3 P33032 (/TAS) P33032 (/TAS) P41968 (/TAS)
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP).
3 P32245 (/TAS) P32245 (/TAS) P32245 (/TAS)
Feeding behavior GO:0007631
Behavior associated with the intake of food.
3 P32245 (/TAS) P32245 (/TAS) P32245 (/TAS)
Regulation of feeding behavior GO:0060259
Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.
3 P33033 (/IMP) P33033 (/IMP) P70596 (/IMP)
Diet induced thermogenesis GO:0002024
The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system.
2 P56450 (/ISO) P56450 (/ISO)
Regulation of heart rate GO:0002027
Any process that modulates the frequency or rate of heart contraction.
2 P33033 (/ISO) P33033 (/ISO)
Energy reserve metabolic process GO:0006112
The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen.
2 B0V1P1 (/IDA) P70596 (/IDA)
Energy reserve metabolic process GO:0006112
The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen.
2 P56450 (/ISO) P56450 (/ISO)
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP).
2 P33033 (/ISO) P33033 (/ISO)
Feeding behavior GO:0007631
Behavior associated with the intake of food.
2 P56450 (/IMP) P56450 (/IMP)
Feeding behavior GO:0007631
Behavior associated with the intake of food.
2 P56450 (/ISO) P56450 (/ISO)
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
2 P33033 (/ISO) P33033 (/ISO)
Regulation of metabolic process GO:0019222
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
2 P56450 (/IMP) P56450 (/IMP)
Insulin secretion GO:0030073
The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.
2 P56450 (/IGI) P56450 (/IGI)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
2 P56450 (/IMP) P56450 (/IMP)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
2 P33033 (/IMP) P33033 (/IMP)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
2 P32244 (/ISS) P41968 (/ISS)
Homoiothermy GO:0042309
Any homoeostatic process in which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment.
2 P33033 (/ISO) P33033 (/ISO)
Locomotor rhythm GO:0045475
The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
2 P33033 (/IMP) P33033 (/IMP)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
2 P56450 (/ISO) P56450 (/ISO)
Regulation of feeding behavior GO:0060259
Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.
2 P56450 (/ISO) P56450 (/ISO)
Negative regulation of feeding behavior GO:2000252
Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior.
2 B0V1P1 (/IMP) P70596 (/IMP)
Negative regulation of feeding behavior GO:2000252
Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior.
2 P56450 (/ISO) P56450 (/ISO)
Regulation of grooming behavior GO:2000821
Any process that modulates the frequency, rate or extent of grooming behavior.
2 P56450 (/ISO) P56450 (/ISO)
Diet induced thermogenesis GO:0002024
The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system.
1 P70596 (/IDA)
Regulation of heart rate GO:0002027
Any process that modulates the frequency or rate of heart contraction.
1 P32244 (/IMP)
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP).
1 P32244 (/IDA)
Phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
1 P41968 (/TAS)
Feeding behavior GO:0007631
Behavior associated with the intake of food.
1 P70596 (/IDA)
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
1 P32244 (/IMP)
Regulation of growth GO:0040008
Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.
1 B0V1P1 (/IGI)
Homoiothermy GO:0042309
Any homoeostatic process in which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment.
1 P32244 (/IMP)
Locomotor rhythm GO:0045475
The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
1 P32244 (/ISS)
Sodium ion homeostasis GO:0055078
Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell.
1 P32244 (/IEP)
Regulation of feeding behavior GO:0060259
Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.
1 P32244 (/ISS)
Energy homeostasis GO:0097009
Any process involved in the balance between food intake (energy input) and energy expenditure.
1 B0V1P1 (/IDA)
Regulation of grooming behavior GO:2000821
Any process that modulates the frequency, rate or extent of grooming behavior.
1 P70596 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P32245 (/TAS) P32245 (/TAS) P32245 (/TAS) P33032 (/TAS) P33032 (/TAS) P41968 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 P32244 (/TAS) P33032 (/TAS) P33032 (/TAS) P41968 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 P32245 (/TAS) P32245 (/TAS) P32245 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P56450 (/ISO) P56450 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P70596 (/IDA) Q7ZTA3 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P56450 (/ISO) P56450 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P70596 (/IDA)