The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 537: 5-hydroxytryptamine (Serotonin) receptor 2A, isofo...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Gq/11-coupled serotonin receptor activity GO:0001587
Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels.
|
6 | A8JQT4 (/NAS) E1JJ46 (/NAS) Q24511 (/NAS) Q6AWQ4 (/NAS) Q8IPN2 (/NAS) Q9VN38 (/NAS) |
|
G protein-coupled serotonin receptor activity GO:0004993
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
|
6 | A8JQT4 (/IDA) E1JJ46 (/IDA) Q24511 (/IDA) Q6AWQ4 (/IDA) Q8IPN2 (/IDA) Q9VN38 (/IDA) |
|
G protein-coupled serotonin receptor activity GO:0004993
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
|
6 | A8JQT4 (/ISS) E1JJ46 (/ISS) Q24511 (/ISS) Q6AWQ4 (/ISS) Q8IPN2 (/ISS) Q9VN38 (/ISS) |
|
G protein-coupled serotonin receptor activity GO:0004993
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
|
6 | A8JQT4 (/TAS) E1JJ46 (/TAS) Q24511 (/TAS) Q6AWQ4 (/TAS) Q8IPN2 (/TAS) Q9VN38 (/TAS) |
|
G protein-coupled amine receptor activity GO:0008227
Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
6 | A8JQT4 (/ISS) E1JJ46 (/ISS) Q24511 (/ISS) Q6AWQ4 (/ISS) Q8IPN2 (/ISS) Q9VN38 (/ISS) |
There are 6 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Serotonin receptor signaling pathway GO:0007210
The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.
|
6 | A8JQT4 (/IDA) E1JJ46 (/IDA) Q24511 (/IDA) Q6AWQ4 (/IDA) Q8IPN2 (/IDA) Q9VN38 (/IDA) |
|
Serotonin receptor signaling pathway GO:0007210
The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.
|
6 | A8JQT4 (/IMP) E1JJ46 (/IMP) Q24511 (/IMP) Q6AWQ4 (/IMP) Q8IPN2 (/IMP) Q9VN38 (/IMP) |
|
Serotonin receptor signaling pathway GO:0007210
The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.
|
6 | A8JQT4 (/ISS) E1JJ46 (/ISS) Q24511 (/ISS) Q6AWQ4 (/ISS) Q8IPN2 (/ISS) Q9VN38 (/ISS) |
|
Serotonin receptor signaling pathway GO:0007210
The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.
|
6 | A8JQT4 (/TAS) E1JJ46 (/TAS) Q24511 (/TAS) Q6AWQ4 (/TAS) Q8IPN2 (/TAS) Q9VN38 (/TAS) |
|
Germ-band extension GO:0007377
Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further.
|
6 | A8JQT4 (/IMP) E1JJ46 (/IMP) Q24511 (/IMP) Q6AWQ4 (/IMP) Q8IPN2 (/IMP) Q9VN38 (/IMP) |
|
Positive regulation of feeding behavior GO:2000253
Any process that activates or increases the frequency, rate or extent of feeding behavior.
|
6 | A8JQT4 (/IMP) E1JJ46 (/IMP) Q24511 (/IMP) Q6AWQ4 (/IMP) Q8IPN2 (/IMP) Q9VN38 (/IMP) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
6 | A8JQT4 (/IDA) E1JJ46 (/IDA) Q24511 (/IDA) Q6AWQ4 (/IDA) Q8IPN2 (/IDA) Q9VN38 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
6 | A8JQT4 (/ISS) E1JJ46 (/ISS) Q24511 (/ISS) Q6AWQ4 (/ISS) Q8IPN2 (/ISS) Q9VN38 (/ISS) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
6 | A8JQT4 (/ISS) E1JJ46 (/ISS) Q24511 (/ISS) Q6AWQ4 (/ISS) Q8IPN2 (/ISS) Q9VN38 (/ISS) |