The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 361: Dopamine receptor D4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591
Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity.
2 P21917 (/IDA) P21917 (/IDA)
Dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591
Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity.
2 P21917 (/IMP) P21917 (/IMP)
Dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591
Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity.
2 P21917 (/ISS) P21917 (/ISS)
Dopamine neurotransmitter receptor activity GO:0004952
Combining with the neurotransmitter dopamine to initiate a change in cell activity.
2 P21917 (/IDA) P21917 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P21917 (/IPI) P21917 (/IPI)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
2 P21917 (/IDA) P21917 (/IDA)
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
2 P21917 (/NAS) P21917 (/NAS)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
2 P21917 (/IDA) P21917 (/IDA)
Dopamine binding GO:0035240
Interacting selectively and non-covalently with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine.
2 P21917 (/IDA) P21917 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P21917 (/IPI) P21917 (/IPI)
Epinephrine binding GO:0051379
Interacting selectively and non-covalently with epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine.
2 P21917 (/IDA) P21917 (/IDA)
Norepinephrine binding GO:0051380
Interacting selectively and non-covalently with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.
2 P21917 (/IDA) P21917 (/IDA)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
2 P21917 (/IDA) P21917 (/IDA)
Behavioral fear response GO:0001662
An acute behavioral change resulting from a perceived external threat.
2 P21917 (/NAS) P21917 (/NAS)
Response to amphetamine GO:0001975
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine.
2 P21917 (/ISS) P21917 (/ISS)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
2 P21917 (/IC) P21917 (/IC)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P21917 (/TAS) P21917 (/TAS)
Adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195
The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).
2 P21917 (/IDA) P21917 (/IDA)
Adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195
The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).
2 P21917 (/IMP) P21917 (/IMP)
Dopamine receptor signaling pathway GO:0007212
The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.
2 P21917 (/IDA) P21917 (/IDA)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
2 P21917 (/ISS) P21917 (/ISS)
Positive regulation of sodium:proton antiporter activity GO:0032417
Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
2 P21917 (/IDA) P21917 (/IDA)
Positive regulation of kinase activity GO:0033674
Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
2 P21917 (/IDA) P21917 (/IDA)
Response to histamine GO:0034776
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.
2 P21917 (/IDA) P21917 (/IDA)
Social behavior GO:0035176
Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group.
2 P21917 (/NAS) P21917 (/NAS)
Regulation of dopamine metabolic process GO:0042053
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine.
2 P21917 (/ISS) P21917 (/ISS)
Dopamine metabolic process GO:0042417
The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.
2 P21917 (/IC) P21917 (/IC)
Fear response GO:0042596
The response of an organism to a perceived external threat.
2 P21917 (/ISS) P21917 (/ISS)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
2 P21917 (/ISS) P21917 (/ISS)
Behavioral response to cocaine GO:0048148
Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus.
2 P21917 (/ISS) P21917 (/ISS)
Behavioral response to ethanol GO:0048149
Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.
2 P21917 (/TAS) P21917 (/TAS)
Arachidonic acid secretion GO:0050482
The controlled release of arachidonic acid from a cell or a tissue.
2 P21917 (/IDA) P21917 (/IDA)
Negative regulation of protein secretion GO:0050709
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
2 P21917 (/IDA) P21917 (/IDA)
Positive regulation of dopamine uptake involved in synaptic transmission GO:0051586
Any process that activates or increases the frequency, rate or extent of the directed movement of dopamine into a cell.
2 P21917 (/IC) P21917 (/IC)
Inhibitory postsynaptic potential GO:0060080
A process that causes a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.
2 P21917 (/ISS) P21917 (/ISS)
Negative regulation of voltage-gated calcium channel activity GO:1901386
Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated calcium channel activity.
2 P21917 (/IDA) P21917 (/IDA)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P21917 (/IDA) P21917 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P21917 (/TAS) P21917 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P21917 (/IDA) P21917 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P21917 (/IDA) P21917 (/IDA)