The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 212: Prostaglandin E2 receptor EP2 subtype

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Prostaglandin E receptor activity GO:0004957
Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity.
3 Q2MV23 (/IDA) Q62928 (/IDA) Q6PFT8 (/IDA)
Prostaglandin E receptor activity GO:0004957
Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity.
2 Q62053 (/ISO) Q62053 (/ISO)
Prostaglandin E receptor activity GO:0004957
Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity.
1 P43116 (/TAS)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
2 Q62053 (/IDA) Q62053 (/IDA)
Exocrine pancreas development GO:0031017
The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells.
2 Q2MV23 (/IGI) Q6PFT8 (/IGI)
Exocrine pancreas development GO:0031017
The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells.
2 Q2MV23 (/IMP) Q6PFT8 (/IMP)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 Q62053 (/IMP) Q62053 (/IMP)
Response to progesterone GO:0032570
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.
2 Q62053 (/IDA) Q62053 (/IDA)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
2 Q62053 (/IGI) Q62053 (/IGI)
Pronephros development GO:0048793
The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.
2 Q2MV23 (/IMP) Q6PFT8 (/IMP)
Cellular response to prostaglandin E stimulus GO:0071380
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.
2 Q62053 (/IDA) Q62053 (/IDA)
Positive regulation of gastric mucosal blood circulation GO:1904346
Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation.
2 Q62053 (/ISO) Q62053 (/ISO)
Embryonic liver development GO:1990402
The process occurring during the embryonic phase whose specific outcome is the progression of the liver over time, from its formation to the mature structure.
2 Q2MV23 (/IGI) Q6PFT8 (/IGI)
Embryonic liver development GO:1990402
The process occurring during the embryonic phase whose specific outcome is the progression of the liver over time, from its formation to the mature structure.
2 Q2MV23 (/IMP) Q6PFT8 (/IMP)
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
1 Q62928 (/NAS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 P43116 (/TAS)
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
1 P43116 (/ISS)
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
1 Q9XT82 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q9XT82 (/IMP)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
1 Q9XT82 (/IMP)
Cellular response to prostaglandin E stimulus GO:0071380
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.
1 P43116 (/ISS)
Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress GO:1902219
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress.
1 Q9XT82 (/IMP)
Positive regulation of gastric mucosal blood circulation GO:1904346
Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation.
1 Q62928 (/IDA)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P43116 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P43116 (/TAS)