The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 211: Melanocyte-stimulating hormone receptor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q01726 (/IPI) Q01726 (/IPI) Q01727 (/IPI) Q01727 (/IPI)
Melanocortin receptor activity GO:0004977
Combining with melanocortin to initiate a change in cell activity.
3 A7Y4C2 (/IDA) Q01727 (/IDA) Q01727 (/IDA)
Melanocortin receptor activity GO:0004977
Combining with melanocortin to initiate a change in cell activity.
2 Q01727 (/ISO) Q01727 (/ISO)
Melanocortin receptor activity GO:0004977
Combining with melanocortin to initiate a change in cell activity.
2 Q01726 (/TAS) Q01726 (/TAS)
Corticotropin receptor activity GO:0004978
Combining with corticotropin to initiate a change in cell activity.
2 F1Q9X5 (/IDA) Q7ZTA2 (/IDA)
Melanocyte-stimulating hormone receptor activity GO:0004980
Combining with melanocyte-stimulating hormone to initiate a change in cell activity.
2 Q01727 (/IDA) Q01727 (/IDA)
Melanocyte-stimulating hormone receptor activity GO:0004980
Combining with melanocyte-stimulating hormone to initiate a change in cell activity.
2 Q01726 (/IPI) Q01726 (/IPI)
Melanocyte-stimulating hormone receptor activity GO:0004980
Combining with melanocyte-stimulating hormone to initiate a change in cell activity.
2 Q01727 (/ISO) Q01727 (/ISO)
G protein-coupled peptide receptor activity GO:0008528
Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
2 Q01726 (/TAS) Q01726 (/TAS)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
2 Q01726 (/IPI) Q01726 (/IPI)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
2 Q01727 (/ISO) Q01727 (/ISO)
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
2 Q01727 (/ISO) Q01727 (/ISO)
Melanocortin receptor activity GO:0004977
Combining with melanocortin to initiate a change in cell activity.
1 B6ZGR5 (/IMP)
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
1 B6ZGR5 (/IMP)

There are 30 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
4 F1Q9X5 (/IDA) Q01726 (/IDA) Q01726 (/IDA) Q7ZTA2 (/IDA)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 Q01726 (/TAS) Q01726 (/TAS)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.
2 Q01726 (/TAS) Q01726 (/TAS)
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
2 Q01727 (/ISO) Q01727 (/ISO)
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
2 Q01726 (/TAS) Q01726 (/TAS)
UV protection GO:0009650
Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV.
2 Q01726 (/TAS) Q01726 (/TAS)
Positive regulation of protein kinase A signaling GO:0010739
Any process that increases the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
2 Q01727 (/IDA) Q01727 (/IDA)
Positive regulation of protein kinase A signaling GO:0010739
Any process that increases the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
2 Q01726 (/ISS) Q01726 (/ISS)
Sensory perception of pain GO:0019233
The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
2 Q01727 (/IMP) Q01727 (/IMP)
Adrenal gland development GO:0030325
The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.
2 F1Q9X5 (/IMP) Q7ZTA2 (/IMP)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
2 Q01726 (/IMP) Q01726 (/IMP)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
2 Q01727 (/ISO) Q01727 (/ISO)
Multicellular organismal response to stress GO:0033555
Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
2 F1Q9X5 (/IEP) Q7ZTA2 (/IEP)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2 Q01727 (/IDA) Q01727 (/IDA)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2 Q01726 (/ISS) Q01726 (/ISS)
Melanin biosynthetic process GO:0042438
The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
2 Q01727 (/IMP) Q01727 (/IMP)
Pigmentation GO:0043473
The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
2 Q01727 (/IMP) Q01727 (/IMP)
Pigmentation GO:0043473
The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
2 Q01726 (/TAS) Q01726 (/TAS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 Q01727 (/IDA) Q01727 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 Q01726 (/ISS) Q01726 (/ISS)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
2 Q01727 (/IDA) Q01727 (/IDA)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
2 Q01726 (/ISS) Q01726 (/ISS)
Regulation of feeding behavior GO:0060259
Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.
2 Q01727 (/ISO) Q01727 (/ISO)
UV-damage excision repair GO:0070914
A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs).
2 Q01726 (/IDA) Q01726 (/IDA)
UV-damage excision repair GO:0070914
A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs).
2 Q01727 (/ISO) Q01727 (/ISO)
Positive regulation of protein kinase C signaling GO:0090037
Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
2 Q01727 (/IDA) Q01727 (/IDA)
Positive regulation of protein kinase C signaling GO:0090037
Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
2 Q01726 (/ISS) Q01726 (/ISS)
Positive regulation of feeding behavior GO:2000253
Any process that activates or increases the frequency, rate or extent of feeding behavior.
2 Q01727 (/ISO) Q01727 (/ISO)
Regulation of feeding behavior GO:0060259
Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.
1 B6ZGR5 (/IMP)
Positive regulation of feeding behavior GO:2000253
Any process that activates or increases the frequency, rate or extent of feeding behavior.
1 B6ZGR5 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 F1Q9X5 (/IDA) Q01726 (/IDA) Q01726 (/IDA) Q7ZTA2 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 F1Q9X5 (/IDA) Q7ZTA2 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q01727 (/ISO) Q01727 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q01726 (/TAS) Q01726 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q01726 (/TAS) Q01726 (/TAS)