The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 181: Thyrotropin receptor
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
3 | Q8SX01 (/IDA) Q94979 (/IDA) Q9VEG4 (/IDA) |
|
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
3 | Q8SX01 (/ISS) Q94979 (/ISS) Q9VEG4 (/ISS) |
|
Neuropeptide receptor activity GO:0008188
Combining with a neuropeptide to initiate a change in cell activity.
|
3 | Q8SX01 (/ISM) Q94979 (/ISM) Q9VEG4 (/ISM) |
|
Protein-hormone receptor activity GO:0016500
Combining with a protein hormone to initiate a change in cell activity.
|
3 | Q8SX01 (/IDA) Q94979 (/IDA) Q9VEG4 (/IDA) |
|
Protein-hormone receptor activity GO:0016500
Combining with a protein hormone to initiate a change in cell activity.
|
3 | Q8SX01 (/ISS) Q94979 (/ISS) Q9VEG4 (/ISS) |
|
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
|
3 | Q8SX01 (/IPI) Q94979 (/IPI) Q9VEG4 (/IPI) |
|
Luteinizing hormone receptor activity GO:0004964
Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity.
|
1 | Q98T85 (/IDA) |
|
Luteinizing hormone receptor activity GO:0004964
Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity.
|
1 | Q98T85 (/IMP) |
|
Choriogonadotropin hormone binding GO:0038106
Interacting selectively and non-covalently with choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit.
|
1 | Q98T85 (/IDA) |
There are 6 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
3 | Q8SX01 (/IDA) Q94979 (/IDA) Q9VEG4 (/IDA) |
|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
3 | Q8SX01 (/ISM) Q94979 (/ISM) Q9VEG4 (/ISM) |
|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
3 | Q8SX01 (/ISS) Q94979 (/ISS) Q9VEG4 (/ISS) |
|
Hormone-mediated signaling pathway GO:0009755
A series of molecular signals mediated by the detection of a hormone.
|
3 | Q8SX01 (/IDA) Q94979 (/IDA) Q9VEG4 (/IDA) |
|
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
|
3 | Q8SX01 (/IDA) Q94979 (/IDA) Q9VEG4 (/IDA) |
|
Response to human chorionic gonadotropin GO:0044752
Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus.
|
1 | Q98T85 (/IMP) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | Q8SX01 (/IDA) Q94979 (/IDA) Q9VEG4 (/IDA) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | Q8SX01 (/ISM) Q94979 (/ISM) Q9VEG4 (/ISM) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | Q8SX01 (/ISS) Q94979 (/ISS) Q9VEG4 (/ISS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q98T85 (/IC) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q98T85 (/IDA) |