The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 170: Free fatty acid receptor 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fatty acid binding GO:0005504
Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
5 C8YUV0 (/ISS) C8YUV0 (/ISS) C8YUV0 (/ISS) Q2AC31 (/ISS) Q5NUL3 (/ISS)
Taste receptor activity GO:0008527
Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste.
5 I6QEA2 (/IMP) Q7TMA4 (/IMP) Q7TMA4 (/IMP) Q7TMA4 (/IMP) R4GKJ9 (/IMP)
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
3 Q7TMA4 (/IDA) Q7TMA4 (/IDA) Q7TMA4 (/IDA)
Fatty acid binding GO:0005504
Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
3 Q7TMA4 (/IDA) Q7TMA4 (/IDA) Q7TMA4 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q7TMA4 (/IPI) Q7TMA4 (/IPI) Q7TMA4 (/IPI)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of glucose transmembrane transport GO:0010827
Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
5 C8YUV0 (/ISS) C8YUV0 (/ISS) C8YUV0 (/ISS) Q2AC31 (/ISS) Q5NUL3 (/ISS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
5 C8YUV0 (/ISS) C8YUV0 (/ISS) C8YUV0 (/ISS) Q2AC31 (/ISS) Q5NUL3 (/ISS)
Negative regulation of cytokine secretion GO:0050710
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell.
5 C8YUV0 (/ISS) C8YUV0 (/ISS) C8YUV0 (/ISS) Q2AC31 (/ISS) Q5NUL3 (/ISS)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
5 C8YUV0 (/ISS) C8YUV0 (/ISS) C8YUV0 (/ISS) Q2AC31 (/ISS) Q5NUL3 (/ISS)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
5 C8YUV0 (/ISS) C8YUV0 (/ISS) C8YUV0 (/ISS) Q2AC31 (/ISS) Q5NUL3 (/ISS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
4 Q2AC31 (/IDA) Q7TMA4 (/IDA) Q7TMA4 (/IDA) Q7TMA4 (/IDA)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
3 Q7TMA4 (/ISO) Q7TMA4 (/ISO) Q7TMA4 (/ISO)
Regulation of glucose transmembrane transport GO:0010827
Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 Q7TMA4 (/IDA) Q7TMA4 (/IDA) Q7TMA4 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
3 Q7TMA4 (/IMP) Q7TMA4 (/IMP) Q7TMA4 (/IMP)
Fat cell differentiation GO:0045444
The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
3 Q7TMA4 (/IMP) Q7TMA4 (/IMP) Q7TMA4 (/IMP)
Hormone secretion GO:0046879
The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.
3 Q7TMA4 (/IDA) Q7TMA4 (/IDA) Q7TMA4 (/IDA)
Negative regulation of cytokine secretion GO:0050710
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell.
3 Q7TMA4 (/IDA) Q7TMA4 (/IDA) Q7TMA4 (/IDA)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
3 Q7TMA4 (/IDA) Q7TMA4 (/IDA) Q7TMA4 (/IDA)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
3 Q7TMA4 (/IMP) Q7TMA4 (/IMP) Q7TMA4 (/IMP)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
3 Q7TMA4 (/IMP) Q7TMA4 (/IMP) Q7TMA4 (/IMP)
Response to oleic acid GO:0034201
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus.
2 I6QEA2 (/IDA) R4GKJ9 (/IDA)
Response to linoleic acid GO:0070543
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus.
2 I6QEA2 (/IDA) R4GKJ9 (/IDA)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
2 Q2AC31 (/ISS) Q5NUL3 (/ISS)
Calcium ion import into cytosol GO:1902656
The directed movement of calcium ion into a cytosol.
2 I6QEA2 (/IMP) R4GKJ9 (/IMP)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 Q5NUL3 (/TAS)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 C8YUV0 (/ISS) C8YUV0 (/ISS) C8YUV0 (/ISS) Q2AC31 (/ISS) Q5NUL3 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 Q5NUL3 (/TAS) Q7TMA4 (/TAS) Q7TMA4 (/TAS) Q7TMA4 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q7TMA4 (/IDA) Q7TMA4 (/IDA) Q7TMA4 (/IDA)
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
3 Q7TMA4 (/IDA) Q7TMA4 (/IDA) Q7TMA4 (/IDA)