The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Rhodopsin 7-helix transmembrane proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 161: type-2 angiotensin II receptor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Angiotensin type II receptor activity GO:0004945
An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms.
4 P35351 (/TAS) P35351 (/TAS) P50052 (/TAS) P50052 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P35351 (/IPI) P35351 (/IPI) P50052 (/IPI) P50052 (/IPI)
Angiotensin type II receptor activity GO:0004945
An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms.
3 P35374 (/IPI) P50052 (/IPI) P50052 (/IPI)
G-protein alpha-subunit binding GO:0001965
Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.
2 P35351 (/TAS) P35351 (/TAS)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
2 P35351 (/IPI) P35351 (/IPI)
Receptor antagonist activity GO:0048019
The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor.
2 P50052 (/TAS) P50052 (/TAS)
Angiotensin type II receptor activity GO:0004945
An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms.
1 P35374 (/IDA)
Angiotensin type II receptor activity GO:0004945
An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms.
1 P35374 (/ISO)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 P35374 (/ISO)

There are 77 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of branching involved in ureteric bud morphogenesis GO:0090190
Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
3 P35351 (/IMP) P35351 (/IMP) P35374 (/IMP)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
2 P35351 (/IEP) P35351 (/IEP)
Blood vessel remodeling GO:0001974
The reorganization or renovation of existing blood vessels.
2 P50052 (/TAS) P50052 (/TAS)
Regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991
The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen.
2 P50052 (/ISS) P50052 (/ISS)
Renin-angiotensin regulation of aldosterone production GO:0002018
The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone.
2 P35351 (/IMP) P35351 (/IMP)
Cellular sodium ion homeostasis GO:0006883
Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
2 P35351 (/IMP) P35351 (/IMP)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
2 P35351 (/IDA) P35351 (/IDA)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2 P50052 (/IDA) P50052 (/IDA)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2 P50052 (/TAS) P50052 (/TAS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P50052 (/IC) P50052 (/IC)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P50052 (/TAS) P50052 (/TAS)
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger GO:0007199
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP).
2 P50052 (/ISS) P50052 (/ISS)
Nitric oxide mediated signal transduction GO:0007263
Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.
2 P50052 (/IC) P50052 (/IC)
Nitric oxide mediated signal transduction GO:0007263
Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.
2 P50052 (/TAS) P50052 (/TAS)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
2 P50052 (/NAS) P50052 (/NAS)
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
2 P50052 (/TAS) P50052 (/TAS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 P35351 (/IMP) P35351 (/IMP)
Response to organonitrogen compound GO:0010243
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
2 P35351 (/IEP) P35351 (/IEP)
Negative regulation of heart rate GO:0010459
Any process that stops, prevents or reduces the frequency or rate of heart contraction.
2 P50052 (/ISS) P50052 (/ISS)
Negative regulation of norepinephrine secretion GO:0010700
Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine.
2 P35351 (/IDA) P35351 (/IDA)
Cerebellar cortex development GO:0021695
The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
2 P35351 (/IMP) P35351 (/IMP)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
2 P35351 (/TAS) P35351 (/TAS)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
2 P50052 (/TAS) P50052 (/TAS)
Negative regulation of icosanoid secretion GO:0032304
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell.
2 P35351 (/IMP) P35351 (/IMP)
Positive regulation of phosphoprotein phosphatase activity GO:0032516
Any process that activates or increases the activity of a phosphoprotein phosphatase.
2 P50052 (/IDA) P50052 (/IDA)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2 P50052 (/ISS) P50052 (/ISS)
Positive regulation of renal sodium excretion GO:0035815
Any process that increases the amount of sodium excreted in urine over a unit of time.
2 P35351 (/IMP) P35351 (/IMP)
Aldosterone secretion GO:0035932
The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.
2 P35351 (/IMP) P35351 (/IMP)
Regulation of protein import into nucleus GO:0042306
Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus.
2 P35351 (/IDA) P35351 (/IDA)
Vasodilation GO:0042311
An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure.
2 P50052 (/IDA) P50052 (/IDA)
Dopamine biosynthetic process GO:0042416
The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.
2 P35351 (/IMP) P35351 (/IMP)
Negative regulation of blood vessel endothelial cell migration GO:0043537
Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
2 P50052 (/NAS) P50052 (/NAS)
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
2 P50052 (/IC) P50052 (/IC)
Negative regulation of fibroblast proliferation GO:0048147
Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
2 P35351 (/IMP) P35351 (/IMP)
Positive regulation of cytokine secretion GO:0050715
Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.
2 P35351 (/IMP) P35351 (/IMP)
Positive regulation of nitric-oxide synthase activity GO:0051000
Any process that activates or increases the activity of the enzyme nitric-oxide synthase.
2 P50052 (/ISS) P50052 (/ISS)
Negative regulation of neurotrophin TRK receptor signaling pathway GO:0051387
Any process that stops, prevents, or reduces the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway.
2 P50052 (/IMP) P50052 (/IMP)
Kidney morphogenesis GO:0060993
Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.
2 P35351 (/IMP) P35351 (/IMP)
Cell growth involved in cardiac muscle cell development GO:0061049
The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.
2 P35351 (/IMP) P35351 (/IMP)
Cellular response to dexamethasone stimulus GO:0071549
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
2 P35351 (/IDA) P35351 (/IDA)
Positive regulation of blood vessel diameter GO:0097755
Any process that increases the diameter of blood vessels.
2 P35351 (/IMP) P35351 (/IMP)
Positive regulation of extrinsic apoptotic signaling pathway GO:2001238
Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway.
2 P50052 (/IMP) P50052 (/IMP)
Regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991
The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen.
1 P35374 (/IMP)
Renin-angiotensin regulation of aldosterone production GO:0002018
The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone.
1 P35374 (/ISO)
Angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0002033
The process that increases the diameter of a blood vessel via the renin-angiotensin system.
1 P35374 (/IMP)
Brain renin-angiotensin system GO:0002035
The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system.
1 P35374 (/IDA)
Cellular sodium ion homeostasis GO:0006883
Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
1 P35374 (/ISO)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 P35374 (/IGI)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 P35374 (/ISO)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 P35374 (/ISO)
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger GO:0007199
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP).
1 P35374 (/IDA)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P35374 (/ISO)
Negative regulation of heart rate GO:0010459
Any process that stops, prevents or reduces the frequency or rate of heart contraction.
1 P35374 (/IMP)
Negative regulation of norepinephrine secretion GO:0010700
Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine.
1 P35374 (/ISO)
Cerebellar cortex development GO:0021695
The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
1 P35374 (/ISO)
Negative regulation of icosanoid secretion GO:0032304
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell.
1 P35374 (/ISO)
Positive regulation of phosphoprotein phosphatase activity GO:0032516
Any process that activates or increases the activity of a phosphoprotein phosphatase.
1 P35374 (/ISO)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 P35374 (/IDA)
Regulation of metanephros size GO:0035566
Any process that modulates the size of a metanephric kidney.
1 P35374 (/IMP)
Exploration behavior GO:0035640
The specific behavior of an organism in response to a novel environment or stimulus.
1 P35374 (/IMP)
Positive regulation of renal sodium excretion GO:0035815
Any process that increases the amount of sodium excreted in urine over a unit of time.
1 P35374 (/ISO)
Aldosterone secretion GO:0035932
The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.
1 P35374 (/ISO)
Regulation of protein import into nucleus GO:0042306
Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus.
1 P35374 (/ISO)
Vasodilation GO:0042311
An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure.
1 P35374 (/ISO)
Dopamine biosynthetic process GO:0042416
The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.
1 P35374 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 P35374 (/IMP)
Negative regulation of fibroblast proliferation GO:0048147
Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
1 P35374 (/ISO)
Positive regulation of cytokine secretion GO:0050715
Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.
1 P35374 (/ISO)
Positive regulation of nitric-oxide synthase activity GO:0051000
Any process that activates or increases the activity of the enzyme nitric-oxide synthase.
1 P35374 (/IDA)
Negative regulation of neurotrophin TRK receptor signaling pathway GO:0051387
Any process that stops, prevents, or reduces the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway.
1 P35374 (/ISO)
Kidney morphogenesis GO:0060993
Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.
1 P35374 (/ISO)
Cell growth involved in cardiac muscle cell development GO:0061049
The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.
1 P35374 (/ISO)
Cellular response to dexamethasone stimulus GO:0071549
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
1 P35374 (/ISO)
Positive regulation of metanephric glomerulus development GO:0072300
Any process that increases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros.
1 P35374 (/IMP)
Positive regulation of branching involved in ureteric bud morphogenesis GO:0090190
Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
1 P35374 (/ISO)
Positive regulation of blood vessel diameter GO:0097755
Any process that increases the diameter of blood vessels.
1 P35374 (/ISO)
Positive regulation of extrinsic apoptotic signaling pathway GO:2001238
Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway.
1 P35374 (/ISO)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P35351 (/IDA) P35351 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P50052 (/TAS) P50052 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P50052 (/IC) P50052 (/IC)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P50052 (/TAS) P50052 (/TAS)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 P35351 (/IDA) P35351 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P35374 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P35374 (/ISO)