The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Rhodopsin 7-helix transmembrane proteins
".
FunFam 157: C-X-C chemokine receptor type 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 13 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Interleukin-8 receptor activity GO:0004918
Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
5 | P25024 (/IDA) P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | P25025 (/IPI) P25025 (/IPI) P25025 (/IPI) P25025 (/IPI) P35343 (/IPI) |
|
Interleukin-8 binding GO:0019959
Interacting selectively and non-covalently with interleukin-8.
|
5 | P25024 (/IPI) P25025 (/IPI) P25025 (/IPI) P25025 (/IPI) P25025 (/IPI) |
|
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
4 | P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) |
|
C-X-C chemokine receptor activity GO:0016494
Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif.
|
4 | P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) |
|
Interleukin-8 receptor activity GO:0004918
Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
2 | P35343 (/ISO) Q810W6 (/ISO) |
|
Chemokine receptor activity GO:0004950
Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
|
2 | P25024 (/TAS) P35343 (/TAS) |
|
Interleukin-8 binding GO:0019959
Interacting selectively and non-covalently with interleukin-8.
|
2 | P35343 (/ISO) Q810W6 (/ISO) |
|
Interleukin-8 receptor activity GO:0004918
Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
1 | P35343 (/TAS) |
|
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
1 | P35343 (/ISO) |
|
G protein-coupled receptor activity GO:0004930
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
|
1 | P25024 (/TAS) |
|
Chemokine receptor activity GO:0004950
Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
|
1 | P35343 (/IDA) |
|
C-X-C chemokine receptor activity GO:0016494
Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif.
|
1 | P35343 (/ISO) |
There are 46 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Dendritic cell chemotaxis GO:0002407
The movement of a dendritic cell in response to an external stimulus.
|
5 | P25024 (/TAS) P25025 (/TAS) P25025 (/TAS) P25025 (/TAS) P25025 (/TAS) |
|
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
5 | P25024 (/IDA) P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) |
|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
5 | P25024 (/TAS) P25025 (/TAS) P25025 (/TAS) P25025 (/TAS) P25025 (/TAS) |
|
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
|
5 | P25024 (/IDA) P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) |
|
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
|
5 | P25024 (/TAS) P25025 (/TAS) P25025 (/TAS) P25025 (/TAS) P25025 (/TAS) |
|
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
4 | P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) |
|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
4 | P25025 (/TAS) P25025 (/TAS) P25025 (/TAS) P25025 (/TAS) |
|
Cellular defense response GO:0006968
A defense response that is mediated by cells.
|
4 | P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) |
|
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
4 | P25025 (/TAS) P25025 (/TAS) P25025 (/TAS) P25025 (/TAS) |
|
Phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
|
4 | P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
4 | P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) |
|
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
|
4 | P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) |
|
Interleukin-8-mediated signaling pathway GO:0038112
A series of molecular signals initiated by the binding of interleukin-8 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
4 | P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) |
|
Neutrophil activation GO:0042119
The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
|
4 | P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) |
|
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
2 | P35343 (/ISO) Q810W6 (/ISO) |
|
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
|
2 | P35343 (/ISO) Q810W6 (/ISO) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
2 | P35343 (/IMP) P35407 (/IMP) |
|
Acute inflammatory response to antigenic stimulus GO:0002438
An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
|
1 | P35407 (/IMP) |
|
Acute inflammatory response to antigenic stimulus GO:0002438
An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
|
1 | P35343 (/ISO) |
|
Positive regulation of leukocyte chemotaxis GO:0002690
Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.
|
1 | P35407 (/IMP) |
|
Positive regulation of leukocyte chemotaxis GO:0002690
Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.
|
1 | P35343 (/ISO) |
|
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
1 | P35343 (/ISO) |
|
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
1 | P35343 (/TAS) |
|
Cellular defense response GO:0006968
A defense response that is mediated by cells.
|
1 | P35343 (/ISO) |
|
Phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
|
1 | P35343 (/ISO) |
|
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
1 | P35407 (/IDA) |
|
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
1 | P35343 (/ISO) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | P35343 (/ISO) |
|
Positive regulation of cardiac muscle cell apoptotic process GO:0010666
Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
|
1 | P35407 (/IMP) |
|
Positive regulation of cardiac muscle cell apoptotic process GO:0010666
Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
|
1 | P35343 (/ISO) |
|
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
|
1 | P35407 (/IMP) |
|
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
|
1 | P35343 (/ISO) |
|
Midbrain development GO:0030901
The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).
|
1 | P35407 (/IEP) |
|
Negative regulation of neutrophil apoptotic process GO:0033030
Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process.
|
1 | P35407 (/IMP) |
|
Negative regulation of neutrophil apoptotic process GO:0033030
Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process.
|
1 | P35343 (/ISO) |
|
Interleukin-8-mediated signaling pathway GO:0038112
A series of molecular signals initiated by the binding of interleukin-8 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | P35343 (/ISO) |
|
Neutrophil activation GO:0042119
The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
|
1 | P35343 (/ISO) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | P35343 (/ISO) |
|
Positive regulation of vascular permeability GO:0043117
Any process that increases the extent to which blood vessels can be pervaded by fluid.
|
1 | P35407 (/IMP) |
|
Positive regulation of vascular permeability GO:0043117
Any process that increases the extent to which blood vessels can be pervaded by fluid.
|
1 | P35343 (/ISO) |
|
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
|
1 | P35407 (/IMP) |
|
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
|
1 | P35343 (/ISO) |
|
Metanephric tubule morphogenesis GO:0072173
The process in which the anatomical structures of a metanephric tubule are generated and organized from an epithelium. A metanephric tubule is an epithelial tube that is part of the metanephros.
|
1 | P35407 (/IMP) |
|
Metanephric tubule morphogenesis GO:0072173
The process in which the anatomical structures of a metanephric tubule are generated and organized from an epithelium. A metanephric tubule is an epithelial tube that is part of the metanephros.
|
1 | P35343 (/ISO) |
|
Positive regulation of neutrophil chemotaxis GO:0090023
Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
|
1 | P35407 (/IMP) |
|
Positive regulation of neutrophil chemotaxis GO:0090023
Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
|
1 | P35343 (/ISO) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | P25024 (/TAS) P25025 (/TAS) P25025 (/TAS) P25025 (/TAS) P25025 (/TAS) |
|
Secretory granule membrane GO:0030667
The lipid bilayer surrounding a secretory granule.
|
5 | P25024 (/TAS) P25025 (/TAS) P25025 (/TAS) P25025 (/TAS) P25025 (/TAS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
4 | P25025 (/TAS) P25025 (/TAS) P25025 (/TAS) P25025 (/TAS) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
4 | P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
4 | P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) |
|
Mast cell granule GO:0042629
Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase.
|
4 | P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) P25025 (/IDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | P35343 (/ISO) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | P35343 (/ISO) |
|
Mast cell granule GO:0042629
Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase.
|
1 | P35343 (/ISO) |