The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

VPS9 domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: VPS9 domain

Rab proteins are a family of signal-transducing GTPases that cycle between active GTP-bound and inactive GDP-bound states. The Rab5 GTPase is an essential regulator of endocytosis and endosome biogenesis. Rab5 is activated by GDP-GTP exchange factors (GEFs) that contain a VPS9 domain and generate the Rab5-GTP complex PMID:16330212. The VPS9 domain catalyzes nucleotide exchange on Rab5 or the yeast homologue VPS21. This domain constitutes the central part of the yeast VPS9 (vacuolar protein sorting-associated) protein, a GEF for VPS21 PMID:17450153. Members of this superfamily share the structure of the VPS9 domain.

GO Diversity

Unique GO annotations
138 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1546 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 12
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 8
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 27
Unique EC:
Unique GO: 138
Unique Species: 1546