The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Glutathione S-transferase 1-1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
27 A1ZB68 (/IDA) A1ZB69 (/IDA) A1ZB70 (/IDA) A1ZB71 (/IDA) A1ZB72 (/IDA) B7Z0S9 (/IDA) P20432 (/IDA) Q4V6J1 (/IDA) Q5BI69 (/IDA) Q7JVI6 (/IDA)
(17 more)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
10 A1ZB73 (/ISS) O76483 (/ISS) O76483 (/ISS) O76483 (/ISS) O76483 (/ISS) O77473 (/ISS) Q6NP69 (/ISS) Q8INS9 (/ISS) Q8T0X2 (/ISS) Q8T8R2 (/ISS)
Nucleic acid binding GO:0003676
Interacting selectively and non-covalently with any nucleic acid.
2 Q6NP69 (/ISS) Q8INS9 (/ISS)
Glutathione peroxidase activity GO:0004602
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
2 Q9VG92 (/TAS) Q9VG98 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q9VG94 (/IPI) Q9VG96 (/IPI)
Glutathione binding GO:0043295
Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.
2 Q6NP69 (/IDA) Q8INS9 (/IDA)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
1 Q9VG97 (/NAS)
DDT-dehydrochlorinase activity GO:0018833
Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+).
1 P20432 (/IDA)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
27 A1ZB68 (/IDA) A1ZB69 (/IDA) A1ZB70 (/IDA) A1ZB71 (/IDA) A1ZB72 (/IDA) B7Z0S9 (/IDA) P20432 (/IDA) Q4V6J1 (/IDA) Q5BI69 (/IDA) Q7JVI6 (/IDA)
(17 more)
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
8 A1ZB73 (/ISS) O76483 (/ISS) O76483 (/ISS) O76483 (/ISS) O76483 (/ISS) O77473 (/ISS) Q8T0X2 (/ISS) Q8T8R2 (/ISS)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 Q7KK90 (/NAS)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
1 Q7KK90 (/IEP)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
1 Q7JYX0 (/IMP)
Ecdysteroid biosynthetic process GO:0045456
The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development.
1 Q7JYX0 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
31 A1ZB68 (/ISS) A1ZB69 (/ISS) A1ZB70 (/ISS) A1ZB71 (/ISS) A1ZB72 (/ISS) A1ZB73 (/ISS) B7Z0S9 (/ISS) P20432 (/ISS) Q4V6J1 (/ISS) Q5BI69 (/ISS)
(21 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
5 O76483 (/ISS) O76483 (/ISS) O76483 (/ISS) O76483 (/ISS) O77473 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q6NP69 (/IDA) Q8INS9 (/IDA)