The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Papain-like viral protease, thumb domain

All coronaviruses such as the SARS virus and the Middle East Respiratory Syndrome (MERS) virus encode in their genomes at least one papain-like protease (PLpro) enzyme which cleaves the viral replicase polyproteins at three sites releasing non-structural protein 1 (nsp1), nsp2 and nsp3. PLpro also possesses deubiquitinating and deISGylating activities. These have been suggested to suppress the host antiviral response by counteracting the post-translational modification of signalling molecules that activate the innate immune response. PLpro is made up of an N-terminal ubiquitin-like domain (found in many ubiquitin-specific proteases or USPs) and a C-terminal catalytic domain containing a right-handed fingers, palm, and thumb domain organisation.

This entry represents the thumb domain which consists of 6 alpha-helices.


GO Diversity

Unique GO annotations
5 Unique GO terms

EC Diversity

Unique EC annotations
5 Unique EC terms

Species Diversity

Unique species annotations
146 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 38
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 26
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 6
Unique EC: 5
Unique GO: 5
Unique Species: 146