The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SAP domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 8: Myocardin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q8IZQ8 (/IPI) Q8R5I7 (/IPI) Q8VIM5 (/IPI)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 Q8IZQ8 (/IDA) Q8VIM5 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 Q8IZQ8 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 Q8VIM5 (/ISO)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q8VIM5 (/ISO)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
1 Q8VIM5 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 Q8IZQ8 (/IPI)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 Q8VIM5 (/ISO)
Histone acetyltransferase binding GO:0035035
Interacting selectively and non-covalently with the enzyme histone acetyltransferase.
1 Q8VIM5 (/IPI)
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
1 Q8VIM5 (/IPI)
RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629
Interacting selectively and non-covalently with a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.
1 Q8VIM5 (/IPI)
RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629
Interacting selectively and non-covalently with a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.
1 Q8IZQ8 (/ISS)
R-SMAD binding GO:0070412
Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein.
1 Q8VIM5 (/IPI)

There are 74 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of histone acetylation GO:0035065
Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein.
3 Q7YR76 (/ISS) Q8IZQ8 (/ISS) Q8R5I7 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 Q8IZQ8 (/IDA) Q8R5I7 (/IDA) Q8VIM5 (/IDA)
Smooth muscle cell differentiation GO:0051145
The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary.
3 Q8IZQ8 (/IMP) Q8R5I7 (/IMP) Q8VIM5 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 Q8IZQ8 (/IDA) Q8VIM5 (/IDA)
Positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation GO:2000721
Any positive regulation of transcription from RNA polymerase II promoter that is involved in smooth muscle cell differentiation.
2 Q8IZQ8 (/IDA) Q8R5I7 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q8VIM5 (/IGI)
Regulation of cell growth by extracellular stimulus GO:0001560
Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.
1 Q8VIM5 (/IDA)
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
1 Q8VIM5 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q8IZQ8 (/IEP)
Cardiac ventricle development GO:0003231
The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
1 Q8VIM5 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation GO:0003257
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell.
1 Q8IZQ8 (/IDA)
Positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation GO:0003257
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell.
1 Q8VIM5 (/ISO)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q8VIM5 (/IDA)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 Q8VIM5 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q8VIM5 (/IDA)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q8IZQ8 (/IDA)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q8VIM5 (/ISO)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q8VIM5 (/IDA)
Negative regulation of cardiac muscle cell apoptotic process GO:0010667
Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
1 Q8VIM5 (/IMP)
Positive regulation of epithelial to mesenchymal transition GO:0010718
Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
1 Q8R5I7 (/IMP)
Positive regulation of epithelial to mesenchymal transition GO:0010718
Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
1 Q8VIM5 (/ISO)
Negative regulation of myotube differentiation GO:0010832
Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
1 Q8VIM5 (/IMP)
Positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511
Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.
1 Q8VIM5 (/IDA)
Cardiocyte differentiation GO:0035051
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual.
1 Q8IZQ8 (/NAS)
Regulation of histone acetylation GO:0035065
Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein.
1 Q8VIM5 (/IDA)
Hepatic stellate cell activation GO:0035733
A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor.
1 Q8R5I7 (/IMP)
Hepatic stellate cell activation GO:0035733
A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor.
1 Q8VIM5 (/ISO)
Vascular smooth muscle cell differentiation GO:0035886
The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell.
1 Q8VIM5 (/IGI)
Muscle cell differentiation GO:0042692
The process in which a relatively unspecialized cell acquires specialized features of a muscle cell.
1 Q8VIM5 (/IMP)
Positive regulation of DNA binding GO:0043388
Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
1 Q8VIM5 (/IGI)
Cellular component maintenance GO:0043954
The organization process that preserves a cellular component in a stable functional or structural state.
1 Q8VIM5 (/IMP)
Regulation of myoblast differentiation GO:0045661
Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
1 Q8VIM5 (/IMP)
Negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736
Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
1 Q8IZQ8 (/IDA)
Negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736
Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
1 Q8VIM5 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8VIM5 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q8VIM5 (/IGI)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q8VIM5 (/ISO)
Positive regulation of smooth muscle contraction GO:0045987
Any process that activates or increases the frequency, rate or extent of smooth muscle contraction.
1 Q8IZQ8 (/IDA)
Positive regulation of smooth muscle contraction GO:0045987
Any process that activates or increases the frequency, rate or extent of smooth muscle contraction.
1 Q8VIM5 (/ISO)
Lung alveolus development GO:0048286
The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.
1 Q8VIM5 (/IMP)
Digestive tract development GO:0048565
The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.
1 Q8VIM5 (/IMP)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q8IZQ8 (/IDA)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q8VIM5 (/ISO)
Smooth muscle cell differentiation GO:0051145
The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary.
1 Q8VIM5 (/ISO)
Regulation of smooth muscle cell differentiation GO:0051150
Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation.
1 Q8R5I7 (/IMP)
Regulation of smooth muscle cell differentiation GO:0051150
Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation.
1 Q8VIM5 (/ISO)
Regulation of smooth muscle cell differentiation GO:0051150
Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation.
1 Q8IZQ8 (/TAS)
Positive regulation of smooth muscle cell differentiation GO:0051152
Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation.
1 Q8IZQ8 (/IDA)
Positive regulation of smooth muscle cell differentiation GO:0051152
Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation.
1 Q8VIM5 (/ISO)
Cardiac muscle cell differentiation GO:0055007
The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
1 Q8VIM5 (/IMP)
Cardiac muscle cell differentiation GO:0055007
The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
1 Q8IZQ8 (/ISS)
Ventricular cardiac muscle cell differentiation GO:0055012
The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ.
1 Q8VIM5 (/IMP)
Uterus development GO:0060065
The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure.
1 Q8VIM5 (/IMP)
Urinary bladder development GO:0060157
The process whose specific outcome is the progression of the urinary bladder over time, from its formation to the mature structure. The urinary bladder is an elastic, muscular sac situated in the anterior part of the pelvic cavity in which urine collects before excretion.
1 Q8VIM5 (/IMP)
Cell growth involved in cardiac muscle cell development GO:0061049
The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.
1 Q8R5I7 (/IMP)
Cell growth involved in cardiac muscle cell development GO:0061049
The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.
1 Q8VIM5 (/ISO)
Cellular response to growth factor stimulus GO:0071363
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
1 Q8R5I7 (/IEP)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q8R5I7 (/IEP)
Ductus arteriosus closure GO:0097070
The morphogenesis process in which the ductus arteriosus changes to no longer permit blood flow after birth. The ductus arteriosus is the shunt between the aorta and the pulmonary artery which allows blood to bypass the fetus' lungs.
1 Q8VIM5 (/IMP)
Negative regulation of amyloid-beta clearance GO:1900222
Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta clearance.
1 Q8IZQ8 (/IMP)
Negative regulation of amyloid-beta clearance GO:1900222
Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta clearance.
1 Q8VIM5 (/ISO)
Regulation of phenotypic switching GO:1900239
Any process that modulates the frequency, rate or extent of phenotypic switching.
1 Q8VIM5 (/IGI)
Positive regulation of transcription from RNA polymerase II promoter involved in heart development GO:1901228
Any positive regulation of transcription from RNA polymerase II promoter that is involved in heart development.
1 Q8VIM5 (/IDA)
Negative regulation of vascular smooth muscle cell proliferation GO:1904706
Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation.
1 Q8VIM5 (/IDA)
Negative regulation of vascular associated smooth muscle cell migration GO:1904753
Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration.
1 Q8VIM5 (/IDA)
Negative regulation of platelet-derived growth factor receptor-beta signaling pathway GO:2000587
Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway.
1 Q8VIM5 (/IDA)
Positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation GO:2000721
Any positive regulation of transcription from RNA polymerase II promoter that is involved in smooth muscle cell differentiation.
1 Q8VIM5 (/ISO)
Positive regulation of cardiac vascular smooth muscle cell differentiation GO:2000724
Any process that activates or increases the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation.
1 Q8R5I7 (/IDA)
Positive regulation of cardiac vascular smooth muscle cell differentiation GO:2000724
Any process that activates or increases the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation.
1 Q8VIM5 (/ISO)
Positive regulation of cardiac vascular smooth muscle cell differentiation GO:2000724
Any process that activates or increases the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation.
1 Q8IZQ8 (/ISS)
Positive regulation of cardiac muscle cell differentiation GO:2000727
Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation.
1 Q8IZQ8 (/IDA)
Positive regulation of cardiac muscle cell differentiation GO:2000727
Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation.
1 Q8VIM5 (/ISO)
Negative regulation of skeletal muscle cell differentiation GO:2001015
Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation.
1 Q8IZQ8 (/IDA)
Negative regulation of skeletal muscle cell differentiation GO:2001015
Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation.
1 Q8VIM5 (/ISO)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q8IZQ8 (/IDA) Q8VIM5 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q7YR76 (/ISS) Q8R5I7 (/ISS)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 Q8VIM5 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8VIM5 (/ISO)
SRF-myogenin-E12 complex GO:0070514
A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes.
1 Q8VIM5 (/IC)