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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Cytochrome P450 76C4

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Geraniol 8-hydroxylase. [EC: 1.14.14.83]
Geraniol + [reduced NADPH--hemoprotein reductase] + O(2) = (6E)-8- hydroxygeraniol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • A cytochrome P450 (heme thiolate) protein found in plants.
  • Also hydroxylates nerol and citronellol, cf. EC 1.14.14.84.
  • The recommended numbering of geraniol gives 8-hydroxygeraniol as the product rather than 10-hydroxygeraniol.
  • The cloned enzyme also catalyzed, but less efficiently, the 3'-hydroxylation of naringenin (cf. EC 1.14.14.82).
  • Formerly EC 1.14.13.152.
 5 A0A067YEW2 A0A067YEW2 D1MI46 Q8VWZ7 Q8VWZ7
Oryzalexin E synthase. [EC: 1.14.14.122]
Ent-sandaracopimaradien-3-beta-ol + [reduced NADPH--hemoprotein reductase] + O(2) = oryzalexin E + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • A cytochrome P450 (heme-thiolate) protein isolated from Oryza sativa (rice).
  • Oryzalexin E is a phytoalexin.
  • Formerly EC 1.14.13.192.
 5 A0A0E0NGP7 A0A0E0NGP7 Q6YTF5 Q6Z5I7 Q6Z5I7
Ent-cassa-12,15-diene 11-hydroxylase. [EC: 1.14.14.112]
Ent-cassa-12,15-diene + O(2) + [reduced NADPH--hemoprotein reductase] = ent-11-beta-hydroxycassa-12,15-diene + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • A cytochrome P450 (heme-thiolate) protein.
  • The enzyme from rice (Oryza sativa) is involved in the biosynthesis of the antifungal phytocassanes.
  • Formerly EC 1.14.13.145.
 5 I1P1H1 I1P1H1 Q69X58 Q6YTF1 Q6YTF1
Oryzalexin D synthase. [EC: 1.14.14.123]
Ent-sandaracopimaradien-3-beta-ol + [reduced NADPH--hemoprotein reductase] + O(2) = oryzalexin D + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • A cytochrome P450 (heme-thiolate) protein isolated from Oryza sativa (rice).
  • Oryzalexin D is a phytoalexin.
  • Formerly EC 1.14.13.193.
 4 I1P1H1 I1P1H1 Q6YTF1 Q6YTF1
Nepetalactol monooxygenase. [EC: 1.14.14.161]
(+)-cis,trans-nepetalactol + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = 7-deoxyloganetate + 3 [oxidized NADPH--hemoprotein reductase] + 4 H(2)O.
  • The enzyme, characterized from the plant Catharanthus roseus, is a cytochrome P450 (heme thiolate) protein.
  • It catalyzes three successive reactions in the pathway leading to biosynthesis of monoterpenoid indole alkaloids.
 1 W8JIS5