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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 65: Cytochrome P450 family 7 subfamily B member 1

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
25/26-hydroxycholesterol 7-alpha-hydroxylase. [EC: 1.14.14.29]
(1) Cholest-5-ene-3-beta,25-diol + [reduced NADPH--hemoprotein reductase] + O(2) = cholest-5-ene-3-beta,7-alpha,25-triol + [oxidized NADPH- -hemoprotein reductase] + H(2)O. (2) (25R)-cholest-5-ene-3-beta,26-diol + [reduced NADPH--hemoprotein reductase] + O(2) = (25R)-cholest-5-ene-3-beta,7-alpha,26-triol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • Unlike EC 1.14.14.26, which is specific for its oxysterol substrate, this enzyme can also metabolize the oxysterols 24,25- epoxycholesterol, 22-hydroxycholesterol and 24-hydroxycholesterol, but to a lesser extent.
  • The direct electron donor to the enzyme is EC 1.6.2.4.
  • Formerly EC 1.14.13.60 and EC 1.14.13.100.
 3 O75881 Q60991 Q63688