The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Cytochrome P450
".
FunFam 49: steroid 21-hydroxylase isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Steroid hydroxylase activity GO:0008395
Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.
|
9 | P00191 (/ISS) P03940 (/ISS) P15540 (/ISS) Q2LA59 (/ISS) Q2LA60 (/ISS) Q2LCM1 (/ISS) Q2LCM1 (/ISS) Q8WNW0 (/ISS) Q8WNW0 (/ISS) |
|
Steroid 21-monooxygenase activity GO:0004509
Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O.
|
3 | P08686 (/IDA) P08686 (/IDA) Q64562 (/IDA) |
|
Steroid 21-monooxygenase activity GO:0004509
Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O.
|
2 | P08686 (/TAS) P08686 (/TAS) |
|
Steroid hydroxylase activity GO:0008395
Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.
|
2 | P08686 (/IMP) P08686 (/IMP) |
|
Steroid hydroxylase activity GO:0008395
Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.
|
2 | P08686 (/TAS) P08686 (/TAS) |
|
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
|
2 | P08686 (/IDA) P08686 (/IDA) |
|
Steroid 21-monooxygenase activity GO:0004509
Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O.
|
1 | P03940 (/ISO) |
|
Steroid hydroxylase activity GO:0008395
Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.
|
1 | P03940 (/ISO) |
|
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
|
1 | P03940 (/ISO) |
There are 17 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Steroid metabolic process GO:0008202
The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
|
9 | P00191 (/ISS) P03940 (/ISS) P15540 (/ISS) Q2LA59 (/ISS) Q2LA60 (/ISS) Q2LCM1 (/ISS) Q2LCM1 (/ISS) Q8WNW0 (/ISS) Q8WNW0 (/ISS) |
|
Glucocorticoid biosynthetic process GO:0006704
The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
|
5 | A0A2R8Q0C9 (/IMP) A0A2R8QAP3 (/IMP) A0A2R8RPF8 (/IMP) F1QP74 (/IMP) H0WEK6 (/IMP) |
|
Steroid biosynthetic process GO:0006694
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
|
2 | P08686 (/IDA) P08686 (/IDA) |
|
Glucocorticoid biosynthetic process GO:0006704
The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
|
2 | P08686 (/TAS) P08686 (/TAS) |
|
Mineralocorticoid biosynthetic process GO:0006705
The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
|
2 | P08686 (/TAS) P08686 (/TAS) |
|
Steroid metabolic process GO:0008202
The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
|
2 | P08686 (/IMP) P08686 (/IMP) |
|
Sterol metabolic process GO:0016125
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
|
2 | P08686 (/TAS) P08686 (/TAS) |
|
Steroid biosynthetic process GO:0006694
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
|
1 | P03940 (/ISO) |
|
C21-steroid hormone biosynthetic process GO:0006700
The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.
|
1 | Q64562 (/IMP) |
|
C21-steroid hormone biosynthetic process GO:0006700
The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.
|
1 | P03940 (/ISO) |
|
Mineralocorticoid biosynthetic process GO:0006705
The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
|
1 | Q64562 (/IDA) |
|
Mineralocorticoid biosynthetic process GO:0006705
The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
|
1 | P03940 (/ISO) |
|
Steroid metabolic process GO:0008202
The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
|
1 | P03940 (/ISO) |
|
Progesterone metabolic process GO:0042448
The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants.
|
1 | Q64562 (/IDA) |
|
Progesterone metabolic process GO:0042448
The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants.
|
1 | P03940 (/ISO) |
|
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
|
1 | Q64562 (/IEP) |
|
Cellular response to peptide hormone stimulus GO:0071375
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
|
1 | Q64562 (/IEP) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
2 | P08686 (/TAS) P08686 (/TAS) |