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CATH Superfamily 1.10.600.10

Farnesyl Diphosphate Synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Farnesyl Diphosphate Synthase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 104: Diterpene cyclase DtcycB

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Cembrene A synthase. [EC: 4.2.3.150]
Geranylgeranyl diphosphate = (R)-cembrene A + diphosphate.
  • Isolated from the bacterium Streptomyces sp. SANK 60404.
  • This trifunctional enzyme also produces (R)-nephthenol and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol (cf. EC 4.2.3.149 and EC 4.2.3.151).
 1 M1VDX3
Nephthenol synthase. [EC: 4.2.3.149]
Geranylgeranyl diphosphate + H(2)O = (R)-nephthenol + diphosphate.
  • Two isozymes with this activity were isolated from the bacterium Streptomyces sp. SANK 60404.
  • The enzyme encoded by the DtcycA gene also produces cembrene C (see 4.2.3.148), while the enzyme encoded by the DtcycB gene also produces (R)-cembrene A and (1S,4E,8E,12E)-2,2,5,9,13- pentamethylcyclopentadeca-4,8,12-trien-1-ol (cf. EC 4.2.3.150 and EC 4.2.3.151).
 1 M1VDX3
Pentamethylcyclopentadecatrienol synthase. [EC: 4.2.3.151]
Geranylgeranyl diphosphate + H(2)O = (1S,4E,8E,12E)-2,2,5,9,13- pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate.
  • Isolated from the bacterium Streptomyces sp. SANK 60404.
  • This trifunctional enzyme also produces (R)-nephthenol and (R)- cembrene A (cf. EC 4.2.3.149 and EC 4.2.3.150).
 1 M1VDX3