The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Rho GTPase activation protein
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 72: Protein RGD1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
6 P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
6 P38339 (/IGI) P38339 (/IGI) P38339 (/IGI) P38339 (/IGI) P38339 (/IGI) P38339 (/IGI)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
6 P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA)
Phosphatidylinositol-5-phosphate binding GO:0010314
Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position.
6 P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA)
Phosphatidylinositol-5-phosphate binding GO:0010314
Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position.
6 P38339 (/IMP) P38339 (/IMP) P38339 (/IMP) P38339 (/IMP) P38339 (/IMP) P38339 (/IMP)
Phosphatidylinositol-3-phosphate binding GO:0032266
Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
6 P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA)
Phosphatidylinositol-3-phosphate binding GO:0032266
Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
6 P38339 (/IMP) P38339 (/IMP) P38339 (/IMP) P38339 (/IMP) P38339 (/IMP) P38339 (/IMP)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
6 P38339 (/IPI) P38339 (/IPI) P38339 (/IPI) P38339 (/IPI) P38339 (/IPI) P38339 (/IPI)
Phosphatidylinositol-4-phosphate binding GO:0070273
Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
6 P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA)
Phosphatidylinositol-4-phosphate binding GO:0070273
Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
6 P38339 (/IMP) P38339 (/IMP) P38339 (/IMP) P38339 (/IMP) P38339 (/IMP) P38339 (/IMP)
Phosphatidylinositol-3,5-bisphosphate binding GO:0080025
Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions.
6 P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA)
Phosphatidylinositol-3,5-bisphosphate binding GO:0080025
Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions.
6 P38339 (/IMP) P38339 (/IMP) P38339 (/IMP) P38339 (/IMP) P38339 (/IMP) P38339 (/IMP)

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
6 P38339 (/IGI) P38339 (/IGI) P38339 (/IGI) P38339 (/IGI) P38339 (/IGI) P38339 (/IGI)
Response to acidic pH GO:0010447
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
6 P38339 (/IMP) P38339 (/IMP) P38339 (/IMP) P38339 (/IMP) P38339 (/IMP) P38339 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Prospore membrane GO:0005628
The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe.
6 P38339 (/HDA) P38339 (/HDA) P38339 (/HDA) P38339 (/HDA) P38339 (/HDA) P38339 (/HDA)
Cellular bud GO:0005933
A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated.
6 P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA)
Actin cortical patch GO:0030479
An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae.
6 P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA) P38339 (/IDA)
Mating projection tip GO:0043332
The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
6 P38339 (/HDA) P38339 (/HDA) P38339 (/HDA) P38339 (/HDA) P38339 (/HDA) P38339 (/HDA)