The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Rho GTPase activation protein
".
FunFam 26: Rho GTPase activating protein 4
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
8 | B1AUX5 (/ISO) B1AUY2 (/ISO) B1AUY3 (/ISO) E9PYS6 (/ISO) Q32MS4 (/ISO) Q3TE27 (/ISO) Q80Z68 (/ISO) Q8VHL8 (/ISO) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
8 | B1AUX5 (/ISO) B1AUY2 (/ISO) B1AUY3 (/ISO) E9PYS6 (/ISO) Q32MS4 (/ISO) Q3TE27 (/ISO) Q80Z68 (/ISO) Q8VHL8 (/ISO) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
5 | A0A0G2JVF0 (/IDA) D3YT53 (/IDA) D3YT54 (/IDA) Q19370 (/IDA) Q8K4G7 (/IDA) |
|
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
|
3 | D3YT53 (/IPI) D3YT54 (/IPI) Q19370 (/IPI) |
|
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
|
3 | D3YT53 (/IPI) D3YT54 (/IPI) Q19370 (/IPI) |
|
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
|
1 | P98171 (/TAS) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
1 | P98171 (/TAS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P98171 (/IPI) |
There are 14 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of fibroblast migration GO:0010764
Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.
|
8 | B1AUX5 (/ISO) B1AUY2 (/ISO) B1AUY3 (/ISO) E9PYS6 (/ISO) Q32MS4 (/ISO) Q3TE27 (/ISO) Q80Z68 (/ISO) Q8VHL8 (/ISO) |
|
Negative regulation of axon extension GO:0030517
Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.
|
8 | B1AUX5 (/ISO) B1AUY2 (/ISO) B1AUY3 (/ISO) E9PYS6 (/ISO) Q32MS4 (/ISO) Q3TE27 (/ISO) Q80Z68 (/ISO) Q8VHL8 (/ISO) |
|
Positive regulation of cell-cell adhesion GO:0022409
Any process that activates or increases the rate or extent of cell adhesion to another cell.
|
3 | D3YT53 (/IGI) D3YT54 (/IGI) Q19370 (/IGI) |
|
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
|
3 | D3YT53 (/IGI) D3YT54 (/IGI) Q19370 (/IGI) |
|
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
|
3 | D3YT53 (/IDA) D3YT54 (/IDA) Q19370 (/IDA) |
|
Negative regulation of phagocytosis, engulfment GO:0060101
Any process that stops, prevents, or reduces the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
|
3 | D3YT53 (/IGI) D3YT54 (/IGI) Q19370 (/IGI) |
|
Regulation of cell-cell adhesion involved in gastrulation GO:0070587
Any process that modulates the frequency, rate, or extent of attachment of a cell to another cell affecting gastrulation.
|
3 | D3YT53 (/IGI) D3YT54 (/IGI) Q19370 (/IGI) |
|
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
2 | A0A0G2JVF0 (/IEP) Q8K4G7 (/IEP) |
|
Negative regulation of fibroblast migration GO:0010764
Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.
|
2 | A0A0G2JVF0 (/IMP) Q8K4G7 (/IMP) |
|
Negative regulation of axon extension GO:0030517
Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.
|
2 | A0A0G2JVF0 (/IMP) Q8K4G7 (/IMP) |
|
Regulation of Rho protein signal transduction GO:0035023
Any process that modulates the frequency, rate or extent of Rho protein signal transduction.
|
2 | A0A0G2JVF0 (/NAS) Q8K4G7 (/NAS) |
|
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
|
1 | P98171 (/TAS) |
|
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
|
1 | P98171 (/TAS) |
|
Regulation of small GTPase mediated signal transduction GO:0051056
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
|
1 | P98171 (/TAS) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
8 | B1AUX5 (/ISO) B1AUY2 (/ISO) B1AUY3 (/ISO) E9PYS6 (/ISO) Q32MS4 (/ISO) Q3TE27 (/ISO) Q80Z68 (/ISO) Q8VHL8 (/ISO) |
|
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
|
8 | B1AUX5 (/ISO) B1AUY2 (/ISO) B1AUY3 (/ISO) E9PYS6 (/ISO) Q32MS4 (/ISO) Q3TE27 (/ISO) Q80Z68 (/ISO) Q8VHL8 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | A0A0G2JVF0 (/IDA) P98171 (/IDA) Q8K4G7 (/IDA) |
|
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
|
3 | D3YT53 (/IDA) D3YT54 (/IDA) Q19370 (/IDA) |
|
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
3 | D3YT53 (/IDA) D3YT54 (/IDA) Q19370 (/IDA) |
|
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
|
2 | A0A0G2JVF0 (/IDA) Q8K4G7 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P98171 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P98171 (/TAS) |