The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Death Domain, Fas
".
FunFam 74: NLR family pyrin domain containing 7
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Aspartic-type endopeptidase inhibitor activity GO:0019828
Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.
|
1 | Q8WX94 (/IDA) |
|
Interleukin-1 binding GO:0019966
Interacting selectively and non-covalently with interleukin-1.
|
1 | Q8WX94 (/IPI) |
|
Caspase binding GO:0089720
Interacting selectively and non-covalently with a caspase family protein.
|
1 | Q8WX94 (/IPI) |
There are 6 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of protein processing GO:0010955
Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage.
|
1 | Q8WX94 (/IDA) |
|
Negative regulation of interleukin-1 beta secretion GO:0050713
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.
|
1 | Q8WX94 (/IMP) |
|
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
1 | Q8WX94 (/IEP) |
|
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
|
1 | Q8WX94 (/IEP) |
|
Negative regulation of cytokine production involved in inflammatory response GO:1900016
Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.
|
1 | Q8WX94 (/IMP) |
|
Negative regulation of aspartic-type peptidase activity GO:1905246
Any process that stops, prevents or reduces the frequency, rate or extent of aspartic-type peptidase activity.
|
1 | Q8WX94 (/IDA) |
There are 0 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.