The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Death Domain, Fas
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 68: NLR family CARD domain containing 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q3UP24 (/IPI) Q9NPP4 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q3UP24 (/IPI) Q9NPP4 (/IPI)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 Q9NPP4 (/TAS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q9NPP4 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q3UP24 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q3UP24 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q3UP24 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9NPP4 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q3UP24 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q3UP24 (/ISS)

There are 30 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Activation of innate immune response GO:0002218
Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
3 F1M649 (/ISS) F1MHT9 (/ISS) Q9NPP4 (/ISS)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
3 F1M649 (/ISS) F1MHT9 (/ISS) Q9NPP4 (/ISS)
Detection of bacterium GO:0016045
The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.
3 F1M649 (/ISS) F1MHT9 (/ISS) Q3UP24 (/ISS)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
3 F1M649 (/ISS) F1MHT9 (/ISS) Q3UP24 (/ISS)
Interleukin-1 beta secretion GO:0050702
The regulated release of interleukin 1 beta from a cell.
3 F1M649 (/ISS) F1MHT9 (/ISS) Q3UP24 (/ISS)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
3 F1M649 (/ISS) F1MHT9 (/ISS) Q9NPP4 (/ISS)
Pyroptosis GO:0070269
A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.
3 F1M649 (/ISS) F1MHT9 (/ISS) Q9NPP4 (/ISS)
Activation of innate immune response GO:0002218
Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
1 Q3UP24 (/IMP)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
1 Q9NPP4 (/IDA)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
1 Q3UP24 (/ISO)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
1 Q3UP24 (/ISS)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 Q3UP24 (/IMP)
Detection of bacterium GO:0016045
The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.
1 Q9NPP4 (/IDA)
Detection of bacterium GO:0016045
The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.
1 Q3UP24 (/IMP)
Detection of bacterium GO:0016045
The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.
1 Q3UP24 (/ISO)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 Q9NPP4 (/IDA)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 Q3UP24 (/IMP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 Q3UP24 (/ISO)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 Q3UP24 (/IMP)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 Q9NPP4 (/TAS)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q9NPP4 (/IDA)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q3UP24 (/ISO)
Regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281
Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis.
1 Q3UP24 (/IMP)
Interleukin-1 beta secretion GO:0050702
The regulated release of interleukin 1 beta from a cell.
1 Q9NPP4 (/IDA)
Interleukin-1 beta secretion GO:0050702
The regulated release of interleukin 1 beta from a cell.
1 Q3UP24 (/IMP)
Interleukin-1 beta secretion GO:0050702
The regulated release of interleukin 1 beta from a cell.
1 Q3UP24 (/ISO)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
1 Q9NPP4 (/IDA)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
1 Q3UP24 (/ISO)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 Q3UP24 (/IDA)
Pyroptosis GO:0070269
A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.
1 Q3UP24 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 F1M649 (/ISS) F1MHT9 (/ISS) Q9NPP4 (/ISS)
IPAF inflammasome complex GO:0072557
A protein complex that consists of three components, IPAF, NAIP and caspase-1, and includes among its functions the sensing of flagellin derived from Legionella pneumophila, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella flexneri.
3 F1M649 (/ISS) F1MHT9 (/ISS) Q9NPP4 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q3UP24 (/TAS) Q9NPP4 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q3UP24 (/IDA)
IPAF inflammasome complex GO:0072557
A protein complex that consists of three components, IPAF, NAIP and caspase-1, and includes among its functions the sensing of flagellin derived from Legionella pneumophila, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella flexneri.
1 Q3UP24 (/IDA)