The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Death Domain, Fas
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 59: Fas-associated via death domain

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 20 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q13158 (/IPI) Q61160 (/IPI) Q8R2E7 (/IPI)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
2 Q13158 (/IPI) Q8R2E7 (/IPI)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
1 Q61160 (/ISO)
Death receptor binding GO:0005123
Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD).
1 Q8R2E7 (/IPI)
Death receptor binding GO:0005123
Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD).
1 Q61160 (/ISO)
Death receptor binding GO:0005123
Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD).
1 Q13158 (/TAS)
Tumor necrosis factor receptor binding GO:0005164
Interacting selectively and non-covalently with the tumor necrosis factor receptor.
1 Q8R2E7 (/IPI)
Tumor necrosis factor receptor binding GO:0005164
Interacting selectively and non-covalently with the tumor necrosis factor receptor.
1 Q61160 (/ISO)
Tumor necrosis factor receptor superfamily binding GO:0032813
Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily.
1 Q13158 (/IPI)
Tumor necrosis factor receptor superfamily binding GO:0032813
Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily.
1 Q61160 (/ISO)
Receptor serine/threonine kinase binding GO:0033612
Interacting selectively and non-covalently with a receptor that possesses protein serine/threonine kinase activity.
1 Q8R2E7 (/IPI)
Receptor serine/threonine kinase binding GO:0033612
Interacting selectively and non-covalently with a receptor that possesses protein serine/threonine kinase activity.
1 Q61160 (/ISO)
Death effector domain binding GO:0035877
Interacting selectively and non-covalently with a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD).
1 Q13158 (/IPI)
Death effector domain binding GO:0035877
Interacting selectively and non-covalently with a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD).
1 Q61160 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q13158 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q61160 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 Q8R2E7 (/IPI)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 Q61160 (/ISO)
Caspase binding GO:0089720
Interacting selectively and non-covalently with a caspase family protein.
1 Q13158 (/IPI)
Caspase binding GO:0089720
Interacting selectively and non-covalently with a caspase family protein.
1 Q61160 (/ISO)

There are 82 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of T cell mediated cytotoxicity GO:0001916
Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.
20 D2CXD5 (/ISS) F6YFY4 (/ISS) G1LKV0 (/ISS) G1RHN0 (/ISS) G3HQ71 (/ISS) G3RWC4 (/ISS) G5BSS5 (/ISS) G7NBN7 (/ISS) H0VIU7 (/ISS) H0XF51 (/ISS)
(10 more)
Positive regulation of adaptive immune response GO:0002821
Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.
20 D2CXD5 (/ISS) F6YFY4 (/ISS) G1LKV0 (/ISS) G1RHN0 (/ISS) G3HQ71 (/ISS) G3RWC4 (/ISS) G5BSS5 (/ISS) G7NBN7 (/ISS) H0VIU7 (/ISS) H0XF51 (/ISS)
(10 more)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
20 D2CXD5 (/ISS) F6YFY4 (/ISS) G1LKV0 (/ISS) G1RHN0 (/ISS) G3HQ71 (/ISS) G3RWC4 (/ISS) G5BSS5 (/ISS) G7NBN7 (/ISS) H0VIU7 (/ISS) H0XF51 (/ISS)
(10 more)
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
20 D2CXD5 (/ISS) F6YFY4 (/ISS) G1LKV0 (/ISS) G1RHN0 (/ISS) G3HQ71 (/ISS) G3RWC4 (/ISS) G5BSS5 (/ISS) G7NBN7 (/ISS) H0VIU7 (/ISS) H0XF51 (/ISS)
(10 more)
T cell differentiation in thymus GO:0033077
The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.
20 D2CXD5 (/ISS) F6YFY4 (/ISS) G1LKV0 (/ISS) G1RHN0 (/ISS) G3HQ71 (/ISS) G3RWC4 (/ISS) G5BSS5 (/ISS) G7NBN7 (/ISS) H0VIU7 (/ISS) H0XF51 (/ISS)
(10 more)
Positive regulation of activated T cell proliferation GO:0042104
Any process that activates or increases the rate or extent of activated T cell proliferation.
20 D2CXD5 (/ISS) F6YFY4 (/ISS) G1LKV0 (/ISS) G1RHN0 (/ISS) G3HQ71 (/ISS) G3RWC4 (/ISS) G5BSS5 (/ISS) G7NBN7 (/ISS) H0VIU7 (/ISS) H0XF51 (/ISS)
(10 more)
T cell homeostasis GO:0043029
The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
20 D2CXD5 (/ISS) F6YFY4 (/ISS) G1LKV0 (/ISS) G1RHN0 (/ISS) G3HQ71 (/ISS) G3RWC4 (/ISS) G5BSS5 (/ISS) G7NBN7 (/ISS) H0VIU7 (/ISS) H0XF51 (/ISS)
(10 more)
Lymph node development GO:0048535
The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes.
20 D2CXD5 (/ISS) F6YFY4 (/ISS) G1LKV0 (/ISS) G1RHN0 (/ISS) G3HQ71 (/ISS) G3RWC4 (/ISS) G5BSS5 (/ISS) G7NBN7 (/ISS) H0VIU7 (/ISS) H0XF51 (/ISS)
(10 more)
Spleen development GO:0048536
The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions.
20 D2CXD5 (/ISS) F6YFY4 (/ISS) G1LKV0 (/ISS) G1RHN0 (/ISS) G3HQ71 (/ISS) G3RWC4 (/ISS) G5BSS5 (/ISS) G7NBN7 (/ISS) H0VIU7 (/ISS) H0XF51 (/ISS)
(10 more)
Thymus development GO:0048538
The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.
20 D2CXD5 (/ISS) F6YFY4 (/ISS) G1LKV0 (/ISS) G1RHN0 (/ISS) G3HQ71 (/ISS) G3RWC4 (/ISS) G5BSS5 (/ISS) G7NBN7 (/ISS) H0VIU7 (/ISS) H0XF51 (/ISS)
(10 more)
Negative regulation of activation-induced cell death of T cells GO:0070236
Any process that stops, prevents, or reduces the frequency, rate or extent of activation-induced cell death of T cells.
20 D2CXD5 (/ISS) F6YFY4 (/ISS) G1LKV0 (/ISS) G1RHN0 (/ISS) G3HQ71 (/ISS) G3RWC4 (/ISS) G5BSS5 (/ISS) G7NBN7 (/ISS) H0VIU7 (/ISS) H0XF51 (/ISS)
(10 more)
Positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation GO:2000454
Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation.
20 D2CXD5 (/ISS) F6YFY4 (/ISS) G1LKV0 (/ISS) G1RHN0 (/ISS) G3HQ71 (/ISS) G3RWC4 (/ISS) G5BSS5 (/ISS) G7NBN7 (/ISS) H0VIU7 (/ISS) H0XF51 (/ISS)
(10 more)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
2 A0A0R4IXF0 (/IDA) Q13158 (/IDA)
Extrinsic apoptotic signaling pathway GO:0097191
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
2 Q13158 (/IDA) Q61160 (/IDA)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
1 Q8R2E7 (/IEP)
Positive regulation of T cell mediated cytotoxicity GO:0001916
Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.
1 Q61160 (/IMP)
Positive regulation of adaptive immune response GO:0002821
Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.
1 Q61160 (/IMP)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 Q13158 (/IMP)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 Q61160 (/ISO)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
1 Q13158 (/TAS)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 Q13158 (/TAS)
Extrinsic apoptotic signaling pathway via death domain receptors GO:0008625
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
1 Q13158 (/TAS)
T cell differentiation GO:0030217
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
1 Q61160 (/TAS)
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
1 Q61160 (/IMP)
Positive regulation of interleukin-8 production GO:0032757
Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.
1 Q13158 (/IDA)
Positive regulation of interleukin-8 production GO:0032757
Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.
1 Q61160 (/ISO)
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
1 Q13158 (/IDA)
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
1 Q61160 (/ISO)
T cell differentiation in thymus GO:0033077
The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.
1 Q61160 (/IMP)
Toll-like receptor 3 signaling pathway GO:0034138
Any series of molecular signals generated as a consequence of binding to toll-like receptor 3.
1 Q13158 (/TAS)
TRIF-dependent toll-like receptor signaling pathway GO:0035666
Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
1 Q13158 (/TAS)
TRAIL-activated apoptotic signaling pathway GO:0036462
An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface.
1 Q13158 (/IDA)
TRAIL-activated apoptotic signaling pathway GO:0036462
An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface.
1 Q61160 (/ISO)
Positive regulation of activated T cell proliferation GO:0042104
Any process that activates or increases the rate or extent of activated T cell proliferation.
1 Q61160 (/IMP)
Response to cocaine GO:0042220
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.
1 Q8R2E7 (/IEP)
T cell homeostasis GO:0043029
The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
1 Q61160 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q13158 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q61160 (/ISO)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
1 Q13158 (/IEP)
Response to morphine GO:0043278
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
1 Q8R2E7 (/IDA)
Response to morphine GO:0043278
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
1 Q61160 (/ISO)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
1 Q61160 (/TAS)
Positive regulation of macrophage differentiation GO:0045651
Any process that activates or increases the frequency, rate or extent of macrophage differentiation.
1 Q13158 (/IMP)
Positive regulation of macrophage differentiation GO:0045651
Any process that activates or increases the frequency, rate or extent of macrophage differentiation.
1 Q61160 (/ISO)
Positive regulation of proteolysis GO:0045862
Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
1 Q13158 (/IDA)
Positive regulation of proteolysis GO:0045862
Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
1 Q61160 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q13158 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q61160 (/ISO)
Behavioral response to cocaine GO:0048148
Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus.
1 Q8R2E7 (/IEP)
Lymph node development GO:0048535
The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes.
1 Q61160 (/IGI)
Spleen development GO:0048536
The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions.
1 Q61160 (/IGI)
Thymus development GO:0048538
The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.
1 Q61160 (/IGI)
Cardiac muscle tissue development GO:0048738
The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.
1 Q61160 (/TAS)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
1 Q13158 (/IMP)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
1 Q61160 (/ISO)
Positive regulation of type I interferon-mediated signaling pathway GO:0060340
Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor.
1 Q13158 (/IMP)
Positive regulation of type I interferon-mediated signaling pathway GO:0060340
Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor.
1 Q61160 (/ISO)
Regulation of necroptotic process GO:0060544
Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.
1 Q8R2E7 (/IMP)
Regulation of necroptotic process GO:0060544
Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.
1 Q61160 (/ISO)
Negative regulation of necroptotic process GO:0060546
Any process that decreases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.
1 Q61160 (/IGI)
Negative regulation of activation-induced cell death of T cells GO:0070236
Any process that stops, prevents, or reduces the frequency, rate or extent of activation-induced cell death of T cells.
1 Q61160 (/IMP)
Cellular response to mechanical stimulus GO:0071260
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 Q13158 (/IEP)
Death-inducing signaling complex assembly GO:0071550
A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a death domain (DD) interaction, as part of the extrinsic apoptotic signaling pathway.
1 Q13158 (/TAS)
Motor neuron apoptotic process GO:0097049
Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.
1 Q61160 (/IMP)
Apoptotic signaling pathway GO:0097190
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
1 Q13158 (/IDA)
Apoptotic signaling pathway GO:0097190
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
1 Q61160 (/ISO)
Apoptotic signaling pathway GO:0097190
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
1 Q13158 (/TAS)
Extrinsic apoptotic signaling pathway GO:0097191
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
1 Q61160 (/IGI)
Extrinsic apoptotic signaling pathway GO:0097191
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
1 Q13158 (/IMP)
Extrinsic apoptotic signaling pathway GO:0097191
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
1 Q61160 (/ISO)
Extrinsic apoptotic signaling pathway GO:0097191
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
1 Q13158 (/TAS)
Extrinsic apoptotic signaling pathway in absence of ligand GO:0097192
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered.
1 Q61160 (/IMP)
Activation of cysteine-type endopeptidase activity GO:0097202
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase.
1 Q13158 (/IDA)
Activation of cysteine-type endopeptidase activity GO:0097202
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase.
1 Q61160 (/ISO)
Necroptotic signaling pathway GO:0097527
A series of molecular signals which triggers the necroptotic death of a cell. The pathway starts with reception of a signal, is characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and ends when the execution phase of necroptosis is triggered.
1 Q13158 (/IMP)
Necroptotic signaling pathway GO:0097527
A series of molecular signals which triggers the necroptotic death of a cell. The pathway starts with reception of a signal, is characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and ends when the execution phase of necroptosis is triggered.
1 Q61160 (/ISO)
Regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041
Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
1 Q13158 (/TAS)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
1 Q13158 (/TAS)
Positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation GO:2000454
Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation.
1 Q61160 (/IMP)
Positive regulation of extrinsic apoptotic signaling pathway GO:2001238
Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway.
1 Q61160 (/IGI)
Positive regulation of extrinsic apoptotic signaling pathway GO:2001238
Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway.
1 Q13158 (/IMP)
Positive regulation of extrinsic apoptotic signaling pathway GO:2001238
Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway.
1 Q61160 (/ISO)

There are 25 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ripoptosome GO:0097342
A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more.
20 D2CXD5 (/ISS) F6YFY4 (/ISS) G1LKV0 (/ISS) G1RHN0 (/ISS) G3HQ71 (/ISS) G3RWC4 (/ISS) G5BSS5 (/ISS) G7NBN7 (/ISS) H0VIU7 (/ISS) H0XF51 (/ISS)
(10 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q13158 (/IDA) Q8R2E7 (/IDA)
Death-inducing signaling complex GO:0031264
A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10.
2 Q13158 (/IDA) Q8R2E7 (/IDA)
CD95 death-inducing signaling complex GO:0031265
A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor.
2 Q13158 (/IDA) Q8R2E7 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8R2E7 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q61160 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q61160 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q13158 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q61160 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q13158 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q13158 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q61160 (/ISO)
Death-inducing signaling complex GO:0031264
A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10.
1 Q61160 (/ISO)
Death-inducing signaling complex GO:0031264
A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10.
1 Q13158 (/TAS)
CD95 death-inducing signaling complex GO:0031265
A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor.
1 Q61160 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q8R2E7 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q61160 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q8R2E7 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q61160 (/ISO)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
1 Q8R2E7 (/IDA)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
1 Q61160 (/ISO)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 Q8R2E7 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 Q61160 (/ISO)
Ripoptosome GO:0097342
A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more.
1 Q13158 (/IDA)
Ripoptosome GO:0097342
A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more.
1 Q61160 (/ISO)