The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Death Domain, Fas
".
FunFam 58: death domain-containing protein CRADD isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
|
2 | P78560 (/IPI) P78560 (/IPI) |
|
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
|
2 | O88843 (/ISO) O88843 (/ISO) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P78560 (/IPI) P78560 (/IPI) |
|
Protein binding, bridging GO:0030674
The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
|
2 | P78560 (/IPI) P78560 (/IPI) |
|
Protein binding, bridging GO:0030674
The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
|
2 | O88843 (/ISO) O88843 (/ISO) |
|
Death domain binding GO:0070513
Interacting selectively and non-covalently with a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB.
|
2 | P78560 (/IPI) P78560 (/IPI) |
|
Death domain binding GO:0070513
Interacting selectively and non-covalently with a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB.
|
2 | O88843 (/ISO) O88843 (/ISO) |
There are 12 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Apoptotic signaling pathway GO:0097190
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
|
4 | O88843 (/ISS) O88843 (/ISS) Q5R6I4 (/ISS) Q5R6I4 (/ISS) |
|
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
|
2 | O88843 (/IGI) O88843 (/IGI) |
|
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
|
2 | P78560 (/IMP) P78560 (/IMP) |
|
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
|
2 | O88843 (/ISO) O88843 (/ISO) |
|
Extrinsic apoptotic signaling pathway via death domain receptors GO:0008625
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
|
2 | P78560 (/IC) P78560 (/IC) |
|
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
|
2 | P78560 (/TAS) P78560 (/TAS) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
2 | P78560 (/IDA) P78560 (/IDA) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
2 | O88843 (/ISO) O88843 (/ISO) |
|
Cellular response to mechanical stimulus GO:0071260
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
|
2 | P78560 (/IEP) P78560 (/IEP) |
|
Apoptotic signaling pathway GO:0097190
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
|
2 | P78560 (/IMP) P78560 (/IMP) |
|
Apoptotic signaling pathway GO:0097190
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
|
2 | O88843 (/ISO) O88843 (/ISO) |
|
Positive regulation of apoptotic signaling pathway GO:2001235
Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.
|
2 | O88843 (/IGI) O88843 (/IGI) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | O88843 (/IDA) O88843 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P78560 (/ISS) P78560 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | O88843 (/IDA) O88843 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P78560 (/ISS) P78560 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P78560 (/TAS) P78560 (/TAS) |