The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 91: Calcium/calmodulin-dependent protein kinase kinase...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calmodulin-dependent protein kinase activity GO:0004683
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin.
3 O88831 (/IDA) P97756 (/IDA) Q3Y416 (/IDA)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
3 Q96RR4 (/TAS) Q96RR4 (/TAS) Q96RR4 (/TAS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 Q96RR4 (/IDA) Q96RR4 (/IDA) Q96RR4 (/IDA)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
3 O88831 (/IDA) P97756 (/IDA) Q3Y416 (/IDA)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
3 Q96RR4 (/TAS) Q96RR4 (/TAS) Q96RR4 (/TAS)
Calmodulin-dependent protein kinase activity GO:0004683
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin.
2 Q8C078 (/ISO) Q8VBY2 (/ISO)
Calmodulin-dependent protein kinase activity GO:0004683
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin.
2 O88831 (/TAS) P97756 (/TAS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 O88831 (/ISS) Q8C078 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q8C078 (/IPI) Q8N5S9 (/IPI)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
2 Q8C078 (/ISO) Q8VBY2 (/ISO)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 O88831 (/TAS)
Calmodulin-dependent protein kinase activity GO:0004683
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin.
1 Q8VBY2 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q8C078 (/ISO)
Protein kinase activator activity GO:0030295
Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.
1 O88831 (/TAS)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
4 Q3Y416 (/IDA) Q96RR4 (/IDA) Q96RR4 (/IDA) Q96RR4 (/IDA)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
4 Q3Y416 (/TAS) Q96RR4 (/TAS) Q96RR4 (/TAS) Q96RR4 (/TAS)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
3 Q96RR4 (/TAS) Q96RR4 (/TAS) Q96RR4 (/TAS)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
3 Q96RR4 (/IMP) Q96RR4 (/IMP) Q96RR4 (/IMP)
Cellular response to reactive oxygen species GO:0034614
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
3 Q96RR4 (/TAS) Q96RR4 (/TAS) Q96RR4 (/TAS)
Regulation of protein kinase activity GO:0045859
Any process that modulates the frequency, rate or extent of protein kinase activity.
3 Q96RR4 (/TAS) Q96RR4 (/TAS) Q96RR4 (/TAS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
3 Q96RR4 (/TAS) Q96RR4 (/TAS) Q96RR4 (/TAS)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
3 Q96RR4 (/IDA) Q96RR4 (/IDA) Q96RR4 (/IDA)
CAMKK-AMPK signaling cascade GO:0061762
A series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity.
3 Q96RR4 (/IMP) Q96RR4 (/IMP) Q96RR4 (/IMP)
Positive regulation of autophagy of mitochondrion GO:1903599
Any process that activates or increases the frequency, rate or extent of mitochondrion degradation by autophagy.
3 Q96RR4 (/IC) Q96RR4 (/IC) Q96RR4 (/IC)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 O88831 (/ISS) Q8C078 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 O88831 (/TAS) P97756 (/TAS)
Activation of protein kinase activity GO:0032147
Any process that initiates the activity of an inactive protein kinase.
2 O88831 (/IDA) P97756 (/IDA)
Activation of protein kinase activity GO:0032147
Any process that initiates the activity of an inactive protein kinase.
2 Q8C078 (/ISO) Q8VBY2 (/ISO)
Positive regulation of protein kinase activity GO:0045860
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
2 P97756 (/IDA) Q3Y416 (/IDA)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
2 O88831 (/ISS) Q8C078 (/ISS)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 Q8C078 (/ISO)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
1 Q3Y416 (/IDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 Q8C078 (/ISO)
Positive regulation of CREB transcription factor activity GO:0032793
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.
1 Q3Y416 (/IDA)
Positive regulation of protein kinase activity GO:0045860
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
1 Q8VBY2 (/ISO)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 Q8C078 (/ISO)
CAMKK-AMPK signaling cascade GO:0061762
A series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity.
1 Q8C078 (/ISO)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
14 A0A024RBP6 (/IDA) A0A024RBP6 (/IDA) A0A024RBP6 (/IDA) A0A024RBP8 (/IDA) A0A024RBP8 (/IDA) A0A024RBP8 (/IDA) A0A024RBQ0 (/IDA) A0A024RBQ0 (/IDA) A0A024RBQ0 (/IDA) A0A024RBQ3 (/IDA)
(4 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
7 O88831 (/TAS) P97756 (/TAS) Q8N5S9 (/TAS) Q8VBY2 (/TAS) Q96RR4 (/TAS) Q96RR4 (/TAS) Q96RR4 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 F1RGR1 (/TAS) Q8N5S9 (/TAS) Q8VBY2 (/TAS) Q96RR4 (/TAS) Q96RR4 (/TAS) Q96RR4 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q96RR4 (/IMP) Q96RR4 (/IMP) Q96RR4 (/IMP)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q3Y416 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q3Y416 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8C078 (/ISO)