The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 86: Non-specific serine/threonine protein kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
32 A4GW50 (/IPI) Q15208 (/IPI) Q15208 (/IPI) Q15208 (/IPI) Q15208 (/IPI) Q15208 (/IPI) Q15208 (/IPI) Q15208 (/IPI) Q15208 (/IPI) Q15208 (/IPI)
(22 more)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
30 Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA)
(20 more)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
30 Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA)
(20 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
30 Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA)
(20 more)
Mitogen-activated protein kinase kinase kinase binding GO:0031435
Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase.
26 Q15208 (/IPI) Q15208 (/IPI) Q15208 (/IPI) Q15208 (/IPI) Q15208 (/IPI) Q15208 (/IPI) Q15208 (/IPI) Q15208 (/IPI) Q15208 (/IPI) Q15208 (/IPI)
(16 more)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
26 Q15208 (/HDA) Q15208 (/HDA) Q15208 (/HDA) Q15208 (/HDA) Q15208 (/HDA) Q15208 (/HDA) Q15208 (/HDA) Q15208 (/HDA) Q15208 (/HDA) Q15208 (/HDA)
(16 more)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
5 Q2LZZ7 (/ISS) Q2LZZ7 (/ISS) Q5ZLR3 (/ISS) Q7TSE6 (/ISS) Q91VJ4 (/ISS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
5 Q2LZZ7 (/ISS) Q2LZZ7 (/ISS) Q5ZLR3 (/ISS) Q7TSE6 (/ISS) Q91VJ4 (/ISS)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
3 Q5ZLR3 (/ISS) Q7TSE6 (/ISS) Q91VJ4 (/ISS)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
2 Q7TSE6 (/ISO) Q91VJ4 (/ISO)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
2 Q7TSE6 (/ISO) Q91VJ4 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 Q7TSE6 (/ISO) Q91VJ4 (/ISO)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 Q582J2 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q582J2 (/ISM)
Mitogen-activated protein kinase kinase kinase binding GO:0031435
Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase.
1 Q91VJ4 (/ISO)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
30 Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA)
(20 more)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
30 Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA)
(20 more)
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
28 A2VDV2 (/ISS) Q5R8M1 (/ISS) Q5R8M1 (/ISS) Q5R8M1 (/ISS) Q5R8M1 (/ISS) Q5R8M1 (/ISS) Q5R8M1 (/ISS) Q5R8M1 (/ISS) Q5R8M1 (/ISS) Q5R8M1 (/ISS)
(18 more)
Cellular protein modification process GO:0006464
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
26 Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA)
(16 more)
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
26 Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA)
(16 more)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
5 Q2LZZ7 (/ISS) Q2LZZ7 (/ISS) Q5ZLR3 (/ISS) Q7TSE6 (/ISS) Q91VJ4 (/ISS)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
5 Q2LZZ7 (/ISS) Q2LZZ7 (/ISS) Q5ZLR3 (/ISS) Q7TSE6 (/ISS) Q91VJ4 (/ISS)
Regulation of cellular component organization GO:0051128
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
5 Q5ZLR3 (/ISS) Q9Y2H1 (/ISS) Q9Y2H1 (/ISS) Q9Y2H1 (/ISS) Q9Y2H1 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 Q7TSE6 (/ISO) Q91VJ4 (/ISO)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2 Q2LZZ7 (/ISS) Q2LZZ7 (/ISS)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2 Q7TSE6 (/ISO) Q91VJ4 (/ISO)
Regulation of dendrite development GO:0050773
Any process that modulates the frequency, rate or extent of dendrite development.
2 Q2LZZ7 (/ISS) Q2LZZ7 (/ISS)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
1 Q582J2 (/IMP)
Cellular protein modification process GO:0006464
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
1 Q91VJ4 (/ISO)
Cellular protein modification process GO:0006464
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
1 Q5ZLR3 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 Q582J2 (/ISM)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 Q582J2 (/IMP)
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
1 Q91VJ4 (/ISO)
Regulation of cellular component organization GO:0051128
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
1 Q7TSE6 (/IDA)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 Q582J2 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
57 A0A024RD18 (/IDA) A0A024RD18 (/IDA) A0A024RD18 (/IDA) A0A024RD18 (/IDA) A0A024RD18 (/IDA) A0A024RD18 (/IDA) A0A024RD18 (/IDA) A0A024RD18 (/IDA) A0A024RD18 (/IDA) A0A024RD18 (/IDA)
(47 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
32 Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA)
(22 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
31 A2VDV2 (/ISS) Q2LZZ7 (/ISS) Q2LZZ7 (/ISS) Q5R8M1 (/ISS) Q5R8M1 (/ISS) Q5R8M1 (/ISS) Q5R8M1 (/ISS) Q5R8M1 (/ISS) Q5R8M1 (/ISS) Q5R8M1 (/ISS)
(21 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
26 Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA) Q15208 (/IDA)
(16 more)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
5 Q5ZLR3 (/ISS) Q9Y2H1 (/ISS) Q9Y2H1 (/ISS) Q9Y2H1 (/ISS) Q9Y2H1 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 Q2LZZ7 (/ISS) Q2LZZ7 (/ISS) Q5ZLR3 (/ISS) Q91VJ4 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q4QIV8 (/ISO) Q7TSE6 (/ISO) Q91VJ4 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q7TSE6 (/ISO) Q91VJ4 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q91VJ4 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q582J2 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q4QIV8 (/ISO)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 Q7TSE6 (/IDA)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
1 Q582J2 (/IDA)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
1 Q4QIV8 (/ISO)