The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 462: Receptor tyrosine kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
4 Q7JQD5 (/ISS) Q7KA88 (/ISS) Q7KT06 (/ISS) Q9BHA9 (/ISS)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
4 Q7JQD5 (/IPI) Q7KA88 (/IPI) Q7KT06 (/IPI) Q9BHA9 (/IPI)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
4 Q7JQD5 (/ISS) Q7KA88 (/ISS) Q7KT06 (/ISS) Q9BHA9 (/ISS)
Fibroblast growth factor-activated receptor activity GO:0005007
Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 Q63240 (/IDA)
Fibroblast growth factor-activated receptor activity GO:0005007
Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 Q63240 (/TAS)
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 Q7KT06 (/IDA)
Fibroblast growth factor binding GO:0017134
Interacting selectively and non-covalently with a fibroblast growth factor.
1 Q63240 (/IDA)
Fibroblast growth factor binding GO:0017134
Interacting selectively and non-covalently with a fibroblast growth factor.
1 Q63240 (/IPI)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cell-matrix adhesion GO:0001954
Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
4 Q7JQD5 (/IMP) Q7KA88 (/IMP) Q7KT06 (/IMP) Q9BHA9 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
4 Q7JQD5 (/ISS) Q7KA88 (/ISS) Q7KT06 (/ISS) Q9BHA9 (/ISS)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
4 Q7JQD5 (/IMP) Q7KA88 (/IMP) Q7KT06 (/IMP) Q9BHA9 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
4 Q7JQD5 (/ISS) Q7KA88 (/ISS) Q7KT06 (/ISS) Q9BHA9 (/ISS)
Dendrite development GO:0016358
The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure.
4 Q7JQD5 (/IMP) Q7KA88 (/IMP) Q7KT06 (/IMP) Q9BHA9 (/IMP)
Epithelial to mesenchymal transition GO:0001837
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
1 Q63240 (/IDA)
Endochondral bone growth GO:0003416
The increase in size or mass of an endochondral bone that contributes to the shaping of the bone.
1 Q63240 (/IEP)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
1 Q63240 (/IDA)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
1 Q63240 (/IMP)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q63240 (/IEP)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
1 Q63240 (/IEP)
Cellular response to fibroblast growth factor stimulus GO:0044344
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.
1 Q63240 (/IEP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 Q63240 (/IEP)
Mesodermal cell differentiation GO:0048333
The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell.
1 Q63240 (/IEP)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
1 Q63240 (/IMP)
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
1 Q63240 (/IDA)
Regulation of dendrite development GO:0050773
Any process that modulates the frequency, rate or extent of dendrite development.
1 Q7KT06 (/IMP)
Cellular response to retinoic acid GO:0071300
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
1 Q63240 (/IEP)
Cellular response to transforming growth factor beta stimulus GO:0071560
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
1 Q63240 (/IEP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
5 Q63240 (/IDA) Q7JQD5 (/IDA) Q7KA88 (/IDA) Q7KT06 (/IDA) Q9BHA9 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 Q7JQD5 (/ISS) Q7KA88 (/ISS) Q7KT06 (/ISS) Q9BHA9 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 Q7JQD5 (/IDA) Q7KA88 (/IDA) Q7KT06 (/IDA) Q9BHA9 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 Q7JQD5 (/ISS) Q7KA88 (/ISS) Q7KT06 (/ISS) Q9BHA9 (/ISS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
4 Q7JQD5 (/IDA) Q7KA88 (/IDA) Q7KT06 (/IDA) Q9BHA9 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q63240 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q63240 (/IDA)