The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 377: Checkpoint protein kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
6 P54199 (/HDA) P54199 (/HDA) P54199 (/HDA) P54199 (/HDA) P54199 (/HDA) P54199 (/HDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
6 P54199 (/IDA) P54199 (/IDA) P54199 (/IDA) P54199 (/IDA) P54199 (/IDA) P54199 (/IDA)
Protein serine/threonine/tyrosine kinase activity GO:0004712
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
6 P54199 (/IDA) P54199 (/IDA) P54199 (/IDA) P54199 (/IDA) P54199 (/IDA) P54199 (/IDA)
Protein serine/threonine/tyrosine kinase activity GO:0004712
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
6 P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 P54199 (/IPI) P54199 (/IPI) P54199 (/IPI) P54199 (/IPI) P54199 (/IPI) P54199 (/IPI)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitotic spindle assembly checkpoint GO:0007094
A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
8 A0A1D8PTW7 (/IMP) A0A1D8PTW7 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
6 P54199 (/HDA) P54199 (/HDA) P54199 (/HDA) P54199 (/HDA) P54199 (/HDA) P54199 (/HDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
6 P54199 (/IDA) P54199 (/IDA) P54199 (/IDA) P54199 (/IDA) P54199 (/IDA) P54199 (/IDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
6 P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP)
Mitotic spindle assembly checkpoint GO:0007094
A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
6 P54199 (/IGI) P54199 (/IGI) P54199 (/IGI) P54199 (/IGI) P54199 (/IGI) P54199 (/IGI)
Spindle pole body duplication GO:0030474
Construction of a new spindle pole body.
6 P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP)
Sister chromatid biorientation GO:0031134
The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles.
6 P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP)
Protein localization to kinetochore GO:0034501
Any process in which a protein is transported to, or maintained at, the kinetochore.
6 P54199 (/IGI) P54199 (/IGI) P54199 (/IGI) P54199 (/IGI) P54199 (/IGI) P54199 (/IGI)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
6 P54199 (/IDA) P54199 (/IDA) P54199 (/IDA) P54199 (/IDA) P54199 (/IDA) P54199 (/IDA)
Spindle assembly GO:0051225
The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.
6 P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP)
Regulation of attachment of spindle microtubules to kinetochore GO:0051988
Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore.
6 P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP) P54199 (/IMP)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 A0A1D8PTW7 (/IMP) A0A1D8PTW7 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Condensed nuclear chromosome kinetochore GO:0000778
A multisubunit complex that is located at the centromeric region of a condensed nuclear chromosome and provides an attachment point for the spindle microtubules.
6 P54199 (/IDA) P54199 (/IDA) P54199 (/IDA) P54199 (/IDA) P54199 (/IDA) P54199 (/IDA)
Spindle pole body GO:0005816
The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome.
6 P54199 (/IDA) P54199 (/IDA) P54199 (/IDA) P54199 (/IDA) P54199 (/IDA) P54199 (/IDA)
Mitotic spindle pole body GO:0044732
The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome.
2 Q5B953 (/IDA) Q5B953 (/IDA)