The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 304: Receptor protein serine/threonine kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transforming growth factor beta receptor activity, type I GO:0005025
Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals.
6 A0A060YBJ3 (/ISS) G3H7H0 (/ISS) G5AZ36 (/ISS) L5KNR8 (/ISS) Q3U485 (/ISS) Q9D5H8 (/ISS)
Transforming growth factor beta binding GO:0050431
Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types.
4 A0A060YBJ3 (/ISS) G3H7H0 (/ISS) G5AZ36 (/ISS) L5KNR8 (/ISS)
Transforming growth factor beta-activated receptor activity GO:0005024
Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 P20792 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P20792 (/IPI)
Activin-activated receptor activity GO:0017002
Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta.
1 Q95T01 (/IDA)
Activin binding GO:0048185
Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits.
1 Q95T01 (/IDA)

There are 40 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
6 A0A060YBJ3 (/ISS) G3H7H0 (/ISS) G5AZ36 (/ISS) L5KNR8 (/ISS) Q3U485 (/ISS) Q9D5H8 (/ISS)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
6 A0A060YBJ3 (/ISS) G3H7H0 (/ISS) G5AZ36 (/ISS) L5KNR8 (/ISS) Q3U485 (/ISS) Q9D5H8 (/ISS)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
6 A0A060YBJ3 (/ISS) G3H7H0 (/ISS) G5AZ36 (/ISS) L5KNR8 (/ISS) Q3U485 (/ISS) Q9D5H8 (/ISS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
6 A0A060YBJ3 (/ISS) G3H7H0 (/ISS) G5AZ36 (/ISS) L5KNR8 (/ISS) Q3U485 (/ISS) Q9D5H8 (/ISS)
Regulation of epithelial to mesenchymal transition GO:0010717
Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
6 A0A060YBJ3 (/ISS) G3H7H0 (/ISS) G5AZ36 (/ISS) L5KNR8 (/ISS) Q3U485 (/ISS) Q9D5H8 (/ISS)
Activin receptor signaling pathway GO:0032924
A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
6 A0A060YBJ3 (/ISS) G3H7H0 (/ISS) G5AZ36 (/ISS) L5KNR8 (/ISS) Q3U485 (/ISS) Q9D5H8 (/ISS)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
6 A0A060YBJ3 (/ISS) G3H7H0 (/ISS) G5AZ36 (/ISS) L5KNR8 (/ISS) Q3U485 (/ISS) Q9D5H8 (/ISS)
Endothelial cell activation GO:0042118
The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
6 A0A060YBJ3 (/ISS) G3H7H0 (/ISS) G5AZ36 (/ISS) L5KNR8 (/ISS) Q3U485 (/ISS) Q9D5H8 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
6 A0A060YBJ3 (/ISS) G3H7H0 (/ISS) G5AZ36 (/ISS) L5KNR8 (/ISS) Q3U485 (/ISS) Q9D5H8 (/ISS)
Mesenchymal cell differentiation GO:0048762
The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.
6 A0A060YBJ3 (/ISS) G3H7H0 (/ISS) G5AZ36 (/ISS) L5KNR8 (/ISS) Q3U485 (/ISS) Q9D5H8 (/ISS)
Cardiac epithelial to mesenchymal transition GO:0060317
A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
6 A0A060YBJ3 (/ISS) G3H7H0 (/ISS) G5AZ36 (/ISS) L5KNR8 (/ISS) Q3U485 (/ISS) Q9D5H8 (/ISS)
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
5 A0A060YBJ3 (/ISS) G3H7H0 (/ISS) G5AZ36 (/ISS) L5KNR8 (/ISS) P20792 (/ISS)
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
1 Q95T01 (/NAS)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
1 Q95T01 (/IMP)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
1 Q95T01 (/TAS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 Q95T01 (/IMP)
Open tracheal system development GO:0007424
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
1 Q95T01 (/IMP)
Primary branching, open tracheal system GO:0007428
Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster.
1 Q95T01 (/IMP)
Malpighian tubule morphogenesis GO:0007443
The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut.
1 Q95T01 (/IMP)
Head involution GO:0008258
Movement of the anterior ectoderm to the interior of the embryo.
1 Q95T01 (/IMP)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 P20792 (/IMP)
Detection of bacterium GO:0016045
The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.
1 P20792 (/IMP)
Larval feeding behavior GO:0030536
Feeding behavior in a larval (immature) organism.
1 P20792 (/IGI)
Larval feeding behavior GO:0030536
Feeding behavior in a larval (immature) organism.
1 P20792 (/IMP)
Germ-line stem cell population maintenance GO:0030718
Any process by which an organism or tissue maintains a population of germ-line stem cells.
1 Q95T01 (/IMP)
Dauer larval development GO:0040024
The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.
1 P20792 (/IGI)
Dauer larval development GO:0040024
The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.
1 P20792 (/IMP)
Germ-line stem cell division GO:0042078
The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.
1 Q95T01 (/IMP)
Regulation of pharyngeal pumping GO:0043051
Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes.
1 P20792 (/IMP)
Dauer entry GO:0043053
Entry into the facultative diapause of the dauer (enduring) larval stage of nematode development.
1 P20792 (/IGI)
Negative regulation of salivary gland boundary specification GO:0045705
Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination.
1 Q95T01 (/TAS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P20792 (/IMP)
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
1 Q95T01 (/IMP)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
1 Q95T01 (/NAS)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
1 P20792 (/IMP)
Regulation of dauer larval development GO:0061065
Any process that modulates the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.
1 P20792 (/IGI)
Regulation of dauer larval development GO:0061065
Any process that modulates the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.
1 P20792 (/IMP)
Negative regulation of dauer larval development GO:0061067
Any process that decreases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.
1 P20792 (/IMP)
Regulation of eating behavior GO:1903998
Any process that modulates the frequency, rate or extent of eating behavior.
1 P20792 (/IGI)
Regulation of eating behavior GO:1903998
Any process that modulates the frequency, rate or extent of eating behavior.
1 P20792 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
6 A0A060YBJ3 (/ISS) G3H7H0 (/ISS) G5AZ36 (/ISS) L5KNR8 (/ISS) Q3U485 (/ISS) Q9D5H8 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
6 A0A060YBJ3 (/ISS) G3H7H0 (/ISS) G5AZ36 (/ISS) L5KNR8 (/ISS) Q3U485 (/ISS) Q9D5H8 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q95T01 (/ISM)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P20792 (/ISS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q569A5 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q569A5 (/IDA)
Activin receptor complex GO:0048179
A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed.
1 Q95T01 (/IPI)