The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 281: Cyclin-dependent kinase 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 P04551 (/IPI) P25859 (/IPI) P25859 (/IPI) P34112 (/IPI) Q2V419 (/IPI) Q8LF80 (/IPI) Q8LF80 (/IPI) Q8LG64 (/IPI)
Cyclin-dependent protein serine/threonine kinase activity GO:0004693
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
4 P04551 (/IDA) P34112 (/IDA) Q8LF80 (/IDA) Q8LF80 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
2 P04551 (/IDA) Q8LG64 (/IDA)
Cyclin-dependent protein serine/threonine kinase activity GO:0004693
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
2 P25859 (/ISS) P25859 (/ISS)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 P04551 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 Q2V419 (/ISS)
Cyclin-dependent protein serine/threonine kinase activity GO:0004693
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
1 P04551 (/EXP)
Cyclin-dependent protein serine/threonine kinase activity GO:0004693
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
1 P04551 (/IGI)
Cyclin-dependent protein serine/threonine kinase activity GO:0004693
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
1 P04551 (/IMP)
Cyclin-dependent protein serine/threonine kinase activity GO:0004693
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
1 Q8LG64 (/TAS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P34112 (/IDA)
Cyclin-dependent protein kinase activity GO:0097472
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
1 P04551 (/IDA)

There are 53 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of G2/M transition of mitotic cell cycle GO:0010389
Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
4 P04551 (/IMP) Q8LF80 (/IMP) Q8LF80 (/IMP) Q8LG64 (/IMP)
Hormone-mediated signaling pathway GO:0009755
A series of molecular signals mediated by the detection of a hormone.
3 Q8LF80 (/IEP) Q8LF80 (/IEP) Q8LG64 (/IEP)
Hormone-mediated signaling pathway GO:0009755
A series of molecular signals mediated by the detection of a hormone.
3 Q8LF80 (/IMP) Q8LF80 (/IMP) Q8LG64 (/IMP)
Regulation of meristem structural organization GO:0009934
Any process that modulates the frequency, rate or extent of meristem organization.
3 Q8LF80 (/IMP) Q8LF80 (/IMP) Q8LG64 (/IMP)
Guard mother cell differentiation GO:0010444
The process in which a meristemoid acquires the specialized features of a guard mother cell.
3 P25859 (/IMP) P25859 (/IMP) Q2V419 (/IMP)
Regulation of DNA endoreduplication GO:0032875
Any process that modulates the frequency, rate or extent of DNA endoreduplication.
3 P25859 (/IMP) P25859 (/IMP) Q2V419 (/IMP)
Regulation of cell cycle G1/S phase transition GO:1902806
Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.
3 P25859 (/IMP) P25859 (/IMP) Q2V419 (/IMP)
Regulation of stomatal complex patterning GO:2000037
Any process that modulates the frequency, rate or extent of stomatal complex patterning.
3 P25859 (/IMP) P25859 (/IMP) Q2V419 (/IMP)
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
2 Q8LF80 (/TAS) Q8LF80 (/TAS)
Unidimensional cell growth GO:0009826
The process in which a cell irreversibly increases in size in one
2 P25859 (/IMP) P25859 (/IMP)
Stomatal complex formation GO:0010376
The process that gives rise to the stomatal complex. This process pertains to the initial formation of a structure from unspecified parts. The stomatal complex is the stomatal guard cells and their associated epidermal cells.
2 P25859 (/IEP) P25859 (/IEP)
Stomatal complex formation GO:0010376
The process that gives rise to the stomatal complex. This process pertains to the initial formation of a structure from unspecified parts. The stomatal complex is the stomatal guard cells and their associated epidermal cells.
2 P25859 (/TAS) P25859 (/TAS)
Histone phosphorylation GO:0016572
The modification of histones by addition of phosphate groups.
2 Q8LF80 (/IDA) Q8LF80 (/IDA)
DNA endoreduplication GO:0042023
Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes.
2 P25859 (/TAS) P25859 (/TAS)
Cotyledon development GO:0048825
The process whose specific outcome is the progression of the cotyledon over time, from its formation to the mature structure. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling.
2 P25859 (/IEP) P25859 (/IEP)
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
1 P04551 (/IMP)
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
1 P04551 (/IMP)
Negative regulation of exit from mitosis GO:0001100
Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).
1 P04551 (/EXP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 P34112 (/IDA)
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
1 Q8LG64 (/TAS)
Positive regulation of septation initiation signaling GO:0031031
Any process that activates or increases the frequency, rate or extent of septation initiation signaling.
1 P04551 (/IC)
Positive regulation of septation initiation signaling GO:0031031
Any process that activates or increases the frequency, rate or extent of septation initiation signaling.
1 P04551 (/IMP)
Negative regulation of conjugation with cellular fusion GO:0031138
Any process that decreases the rate or frequency of conjugation with cellular fusion.
1 P04551 (/IMP)
Positive regulation of exit from mitosis GO:0031536
Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).
1 P04551 (/IMP)
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
1 P04551 (/IMP)
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
1 P04551 (/IMP)
Positive regulation of mitotic metaphase/anaphase transition GO:0045842
Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
1 P04551 (/IMP)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 Q8LG64 (/IDA)
Regulation of meiotic cell cycle GO:0051445
Any process that modulates the rate or extent of progression through the meiotic cell cycle.
1 P04551 (/IMP)
Positive regulation of meiotic cell cycle GO:0051446
Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle.
1 P04551 (/IMP)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 P34112 (/IGI)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 Q2V419 (/TAS)
Regulation of linear element maturation GO:0062123
Any process that modulates the rate, frequency or extent of linear element maturation.
1 P04551 (/IMP)
Response to intra-S DNA damage checkpoint signaling GO:0072429
A process that occurs in response to signals generated as a result of intra-S DNA damage checkpoint signaling.
1 P04551 (/IMP)
Response to mitotic G2 DNA damage checkpoint signaling GO:0072435
A process that occurs in response to signals generated as a result of mitotic G2/M transition DNA damage checkpoint signaling.
1 P04551 (/IMP)
Response to mitotic G2 DNA damage checkpoint signaling GO:0072435
A process that occurs in response to signals generated as a result of mitotic G2/M transition DNA damage checkpoint signaling.
1 P04551 (/IPI)
Response to meiotic DNA replication checkpoint signaling GO:0072441
A process that occurs in response to signals generated as a result of meiotic DNA replication checkpoint signaling.
1 P04551 (/EXP)
Repair of mitotic merotelic kinetochore attachment defect GO:0098783
The cell cycle process that corrects the anomalous association of a single chromatid kinetochore with mitotic spindle microtubules emanating from both spindle poles (otherwise known as merotelic attachment to the spindle).
1 P04551 (/IMP)
Negative regulation of attachment of mitotic spindle microtubules to kinetochore GO:1902424
Any process that stops, prevents or reduces the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation.
1 P04551 (/IMP)
Negative regulation of mitotic spindle elongation GO:1902845
Any process that stops, prevents or reduces the frequency, rate or extent of mitotic spindle elongation.
1 P04551 (/IMP)
Negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding GO:1903026
Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.
1 P04551 (/IDA)
Positive regulation of cellular protein catabolic process GO:1903364
Any process that activates or increases the frequency, rate or extent of cellular protein catabolic process.
1 P04551 (/EXP)
Positive regulation of mitotic chromosome condensation GO:1903380
Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation.
1 P04551 (/IMP)
Positive regulation of mitotic cell cycle DNA replication GO:1903465
Any process that activates or increases the frequency, rate or extent of mitotic cell cycle DNA replication.
1 P04551 (/EXP)
Negative regulation of mitotic DNA replication initiation GO:1903467
Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication.
1 P04551 (/IMP)
Negative regulation of mitotic actomyosin contractile ring assembly GO:1903500
Any process that stops, prevents or reduces the frequency, rate or extent of mitotic actomyosin contractile ring assembly.
1 P04551 (/IMP)
Negative regulation of mitotic telomere tethering at nuclear periphery GO:1904537
Any process that stops, prevents or reduces the frequency, rate or extent of mitotic telomere tethering at nuclear periphery.
1 P04551 (/IPI)
Positive regulation of double-strand break repair via homologous recombination GO:1905168
Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination.
1 P04551 (/IMP)
Positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination GO:1905263
Any process that activates or increases the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination.
1 P04551 (/IMP)
Negative regulation of primary cell septum biogenesis GO:1905757
Any process that stops, prevents or reduces the frequency, rate or extent of primary cell septum biogenesis.
1 P04551 (/IMP)
Negative regulation of anaphase-promoting complex-dependent catabolic process GO:1905785
Any process that stops, prevents or reduces the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process.
1 P04551 (/IMP)
Response to mitotic DNA integrity checkpoint signaling GO:1990820
A process that occurs in response to signals generated as a result of mitotic DNA integrity checkpoint signaling.
1 P04551 (/IGI)
Negative regulation of double-strand break repair via nonhomologous end joining GO:2001033
Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via nonhomologous end joining.
1 P04551 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cyclin-dependent protein kinase holoenzyme complex GO:0000307
Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
3 P04551 (/IDA) Q8LF80 (/IDA) Q8LF80 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P04551 (/IDA) P25859 (/IDA) P25859 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P25859 (/IDA) P25859 (/IDA)
Cyclin-dependent protein kinase holoenzyme complex GO:0000307
Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
1 P04551 (/IPI)
Cyclin-dependent protein kinase holoenzyme complex GO:0000307
Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
1 Q2V419 (/ISS)
Chromosome, centromeric region GO:0000775
The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
1 P04551 (/EXP)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 P04551 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P04551 (/EXP)
Nuclear telomeric heterochromatin GO:0005724
Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus.
1 P04551 (/EXP)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P04551 (/EXP)
Meiotic spindle pole body GO:0035974
The microtubule organizing center that forms as part of the meiotic cell cycle; functionally homologous to the animal cell centrosome.
1 P04551 (/EXP)
Mitotic spindle pole body GO:0044732
The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome.
1 P04551 (/EXP)
Mitotic spindle GO:0072686
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
1 P04551 (/EXP)
Mitotic spindle midzone GO:1990023
The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner.
1 P04551 (/IDA)