The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Transferase(Phosphotransferase) domain 1
".
FunFam 206: Mitogen-activated protein kinase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 10 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
20 |
P14681 (/IPI)
P14681 (/IPI)
P14681 (/IPI)
P14681 (/IPI)
P14681 (/IPI)
P14681 (/IPI)
P14681 (/IPI)
P14681 (/IPI)
P14681 (/IPI)
P14681 (/IPI)
(10 more) |
|
MAP kinase activity GO:0004707
Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
|
16 |
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
(6 more) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
14 |
P14681 (/HDA)
P14681 (/HDA)
P14681 (/HDA)
P14681 (/HDA)
P14681 (/HDA)
P14681 (/HDA)
P14681 (/HDA)
P14681 (/HDA)
P14681 (/HDA)
P14681 (/HDA)
(4 more) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
10 | P14681 (/IPI) P14681 (/IPI) P14681 (/IPI) P14681 (/IPI) P14681 (/IPI) P14681 (/IPI) P14681 (/IPI) P14681 (/IPI) P14681 (/IPI) P14681 (/IPI) |
|
MAP kinase activity GO:0004707
Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
|
4 | O23236 (/ISS) O23236 (/ISS) Q39027 (/ISS) Q39027 (/ISS) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
4 | P16892 (/IPI) P16892 (/IPI) P16892 (/IPI) P16892 (/IPI) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
2 | Q39022 (/IDA) Q39022 (/IDA) |
|
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
|
2 | Q39021 (/IDA) Q39021 (/IDA) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
1 | A5WYZ9 (/ISA) |
|
MAP kinase activity GO:0004707
Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
|
1 | A5WYZ9 (/RCA) |
There are 24 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
16 |
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
(6 more) |
|
Invasive growth in response to glucose limitation GO:0001403
A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae.
|
14 |
P14681 (/IMP)
P14681 (/IMP)
P14681 (/IMP)
P14681 (/IMP)
P14681 (/IMP)
P14681 (/IMP)
P14681 (/IMP)
P14681 (/IMP)
P14681 (/IMP)
P14681 (/IMP)
(4 more) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
14 |
P14681 (/HDA)
P14681 (/HDA)
P14681 (/HDA)
P14681 (/HDA)
P14681 (/HDA)
P14681 (/HDA)
P14681 (/HDA)
P14681 (/HDA)
P14681 (/HDA)
P14681 (/HDA)
(4 more) |
|
Pheromone-dependent signal transduction involved in conjugation with cellular fusion GO:0000750
A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.
|
10 | P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) |
|
Signal transduction involved in filamentous growth GO:0001402
Relaying of environmental signals promoting filamentous growth.
|
10 | P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
10 | P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) |
|
Positive regulation of division septum assembly GO:0010973
Any process that increases the frequency, rate or extent of division septum formation. division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.
|
10 | P14681 (/IGI) P14681 (/IGI) P14681 (/IGI) P14681 (/IGI) P14681 (/IGI) P14681 (/IGI) P14681 (/IGI) P14681 (/IGI) P14681 (/IGI) P14681 (/IGI) |
|
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
10 | P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) P14681 (/IMP) |
|
Pheromone-dependent signal transduction involved in conjugation with cellular fusion GO:0000750
A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.
|
4 | P16892 (/IDA) P16892 (/IDA) P16892 (/IDA) P16892 (/IDA) |
|
Cell cycle arrest GO:0007050
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
|
4 | P16892 (/IMP) P16892 (/IMP) P16892 (/IMP) P16892 (/IMP) |
|
Negative regulation of transposition, RNA-mediated GO:0010526
Any process that decreases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate.
|
4 | P16892 (/IMP) P16892 (/IMP) P16892 (/IMP) P16892 (/IMP) |
|
Negative regulation of MAPK cascade GO:0043409
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.
|
4 | P16892 (/IPI) P16892 (/IPI) P16892 (/IPI) P16892 (/IPI) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
4 | P16892 (/IDA) P16892 (/IDA) P16892 (/IDA) P16892 (/IDA) |
|
Positive regulation of protein export from nucleus GO:0046827
Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.
|
4 | P16892 (/IMP) P16892 (/IMP) P16892 (/IMP) P16892 (/IMP) |
|
Pheromone response MAPK cascade GO:0071507
A MAPK cascade that is part of a pheromone response ending in conjugation with cellular fusion.
|
4 | P16892 (/IDA) P16892 (/IDA) P16892 (/IDA) P16892 (/IDA) |
|
Auxin-activated signaling pathway GO:0009734
A series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription.
|
2 | Q39021 (/TAS) Q39021 (/TAS) |
|
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
2 | Q39027 (/IDA) Q39027 (/IDA) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | A5WYZ9 (/ISA) |
|
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
|
1 | A5WYZ9 (/IEP) |
|
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
|
1 | A5WYZ9 (/IEP) |
|
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
|
1 | A5WYZ9 (/IEP) |
|
Response to salicylic acid GO:0009751
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus.
|
1 | A5WYZ9 (/IEP) |
|
Defense response to fungus, incompatible interaction GO:0009817
A response of an organism to a fungus that prevents the occurrence or spread of disease.
|
1 | A5WYZ9 (/IEP) |
|
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
1 | A5WYZ9 (/IEP) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
14 |
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
P14681 (/IDA)
(4 more) |
|
Cellular bud neck GO:0005935
The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
|
10 | P14681 (/IDA) P14681 (/IDA) P14681 (/IDA) P14681 (/IDA) P14681 (/IDA) P14681 (/IDA) P14681 (/IDA) P14681 (/IDA) P14681 (/IDA) P14681 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | P16892 (/IDA) P16892 (/IDA) P16892 (/IDA) P16892 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
4 | P16892 (/HDA) P16892 (/HDA) P16892 (/HDA) P16892 (/HDA) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
4 | P16892 (/IDA) P16892 (/IDA) P16892 (/IDA) P16892 (/IDA) |
|
Mating projection tip GO:0043332
The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
|
4 | P16892 (/IDA) P16892 (/IDA) P16892 (/IDA) P16892 (/IDA) |