The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Cyclin-like
".
FunFam 33: retinoblastoma-associated protein isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 25 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | P06400 (/IPI) P06400 (/IPI) P13405 (/IPI) P33568 (/IPI) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
4 | P06400 (/IPI) P06400 (/IPI) P13405 (/IPI) P33568 (/IPI) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
4 | P13405 (/ISS) P33568 (/ISS) Q08E68 (/ISS) Q9BDQ3 (/ISS) |
|
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
4 | P13405 (/ISS) P33568 (/ISS) Q08E68 (/ISS) Q9BDQ3 (/ISS) |
|
Disordered domain specific binding GO:0097718
Interacting selectively and non-covalently with a disordered domain of a protein.
|
3 | A0A0D9RYS3 (/IPI) P06400 (/IPI) P06400 (/IPI) |
|
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
|
2 | P06400 (/IDA) P06400 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | P06400 (/TAS) P06400 (/TAS) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
2 | P06400 (/TAS) P06400 (/TAS) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
2 | P06400 (/NAS) P06400 (/NAS) |
|
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
2 | P06400 (/IDA) P06400 (/IDA) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
2 | P06400 (/IPI) P06400 (/IPI) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
2 | P06400 (/IPI) P06400 (/IPI) |
|
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
|
2 | P06400 (/NAS) P06400 (/NAS) |
|
Phosphoprotein binding GO:0051219
Interacting selectively and non-covalently with a phosphorylated protein.
|
2 | P06400 (/IPI) P06400 (/IPI) |
|
Importin-alpha family protein binding GO:0061676
Interacting selectively and non-covalently with any member of the importin-alpha family.
|
2 | P06400 (/IPI) P06400 (/IPI) |
|
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | P13405 (/ISO) |
|
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
1 | P13405 (/IPI) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | P13405 (/ISO) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | P13405 (/IPI) |
|
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
1 | P13405 (/ISO) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
1 | P13405 (/ISO) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | P13405 (/ISO) |
|
Phosphoprotein binding GO:0051219
Interacting selectively and non-covalently with a phosphorylated protein.
|
1 | P13405 (/ISO) |
|
Importin-alpha family protein binding GO:0061676
Interacting selectively and non-covalently with any member of the importin-alpha family.
|
1 | P13405 (/ISO) |
|
Disordered domain specific binding GO:0097718
Interacting selectively and non-covalently with a disordered domain of a protein.
|
1 | P13405 (/ISO) |
There are 108 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
|
4 | P13405 (/ISS) P33568 (/ISS) Q08E68 (/ISS) Q9BDQ3 (/ISS) |
|
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
|
4 | A0JMQ4 (/IGI) A8WGI9 (/IGI) F1Q9D6 (/IGI) Q8JG55 (/IGI) |
|
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
|
4 | A0JMQ4 (/IMP) A8WGI9 (/IMP) F1Q9D6 (/IMP) Q8JG55 (/IMP) |
|
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
|
4 | A0JMQ4 (/IMP) A8WGI9 (/IMP) F1Q9D6 (/IMP) Q8JG55 (/IMP) |
|
Optic nerve development GO:0021554
The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.
|
4 | A0JMQ4 (/IMP) A8WGI9 (/IMP) F1Q9D6 (/IMP) Q8JG55 (/IMP) |
|
Retinal ganglion cell axon guidance GO:0031290
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
|
4 | A0JMQ4 (/IMP) A8WGI9 (/IMP) F1Q9D6 (/IMP) Q8JG55 (/IMP) |
|
Regulation of lipid kinase activity GO:0043550
Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid.
|
4 | P13405 (/ISS) P33568 (/ISS) Q08E68 (/ISS) Q9BDQ3 (/ISS) |
|
Myoblast differentiation GO:0045445
The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.
|
4 | P13405 (/ISS) P33568 (/ISS) Q08E68 (/ISS) Q9BDQ3 (/ISS) |
|
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
|
4 | A0JMQ4 (/IGI) A8WGI9 (/IGI) F1Q9D6 (/IGI) Q8JG55 (/IGI) |
|
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
|
4 | A0JMQ4 (/IMP) A8WGI9 (/IMP) F1Q9D6 (/IMP) Q8JG55 (/IMP) |
|
Anatomical structure maturation GO:0071695
A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state.
|
4 | A0JMQ4 (/IGI) A8WGI9 (/IGI) F1Q9D6 (/IGI) Q8JG55 (/IGI) |
|
Anatomical structure maturation GO:0071695
A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state.
|
4 | A0JMQ4 (/IMP) A8WGI9 (/IMP) F1Q9D6 (/IMP) Q8JG55 (/IMP) |
|
Negative regulation of cold-induced thermogenesis GO:0120163
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
|
4 | P06400 (/ISS) P06400 (/ISS) P33568 (/ISS) R9PXV5 (/ISS) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
3 | P06400 (/IMP) P06400 (/IMP) P13405 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | P06400 (/IDA) P06400 (/IDA) P13405 (/IDA) |
|
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
|
2 | P06400 (/TAS) P06400 (/TAS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | P06400 (/TAS) P06400 (/TAS) |
|
Aortic valve morphogenesis GO:0003180
The process in which the structure of the aortic valve is generated and organized.
|
2 | P06400 (/ISS) P06400 (/ISS) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
2 | P06400 (/TAS) P06400 (/TAS) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P06400 (/NAS) P06400 (/NAS) |
|
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
|
2 | P06400 (/IPI) P06400 (/IPI) |
|
Cell cycle arrest GO:0007050
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
|
2 | P06400 (/TAS) P06400 (/TAS) |
|
Mitotic cell cycle checkpoint GO:0007093
A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.
|
2 | P06400 (/TAS) P06400 (/TAS) |
|
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
|
2 | P06400 (/IEP) P06400 (/IEP) |
|
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
|
2 | P06400 (/IMP) P06400 (/IMP) |
|
Androgen receptor signaling pathway GO:0030521
Any series of molecular signals generated as a consequence of an androgen binding to its receptor.
|
2 | P06400 (/NAS) P06400 (/NAS) |
|
Sister chromatid biorientation GO:0031134
The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles.
|
2 | P06400 (/IMP) P06400 (/IMP) |
|
Maintenance of mitotic sister chromatid cohesion GO:0034088
The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle.
|
2 | P06400 (/IMP) P06400 (/IMP) |
|
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
2 | P06400 (/TAS) P06400 (/TAS) |
|
Regulation of lipid kinase activity GO:0043550
Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid.
|
2 | P06400 (/IDA) P06400 (/IDA) |
|
Myoblast differentiation GO:0045445
The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.
|
2 | P06400 (/IMP) P06400 (/IMP) |
|
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
|
2 | P13405 (/IMP) P33568 (/IMP) |
|
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
|
2 | P06400 (/ISS) P06400 (/ISS) |
|
Positive regulation of mitotic metaphase/anaphase transition GO:0045842
Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
|
2 | P06400 (/IMP) P06400 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P06400 (/TAS) P06400 (/TAS) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P06400 (/NAS) P06400 (/NAS) |
|
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
|
2 | P06400 (/ISS) P06400 (/ISS) |
|
Protein localization to chromosome, centromeric region GO:0071459
Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome.
|
2 | P06400 (/IMP) P06400 (/IMP) |
|
Negative regulation of protein serine/threonine kinase activity GO:0071901
Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
2 | P06400 (/ISS) P06400 (/ISS) |
|
Regulation of cohesin loading GO:0071922
Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin.
|
2 | P06400 (/IMP) P06400 (/IMP) |
|
Negative regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0071930
Any process that stop, prevents or decreases transcription as part of the G1/S transition of the mitotic cell cycle.
|
2 | P06400 (/TAS) P06400 (/TAS) |
|
Regulation of centromere complex assembly GO:0090230
Any process that modulates the rate, frequency, or extent of centromere complex assembly, the aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex.
|
2 | P06400 (/TAS) P06400 (/TAS) |
|
Negative regulation of tau-protein kinase activity GO:1902948
Any process that stops, prevents or reduces the frequency, rate or extent of tau-protein kinase activity.
|
2 | P06400 (/ISS) P06400 (/ISS) |
|
Positive regulation of extracellular matrix organization GO:1903055
Any process that activates or increases the frequency, rate or extent of extracellular matrix organization.
|
2 | P06400 (/ISS) P06400 (/ISS) |
|
Positive regulation of collagen fibril organization GO:1904028
Any process that activates or increases the frequency, rate or extent of collagen fibril organization.
|
2 | P06400 (/ISS) P06400 (/ISS) |
|
Negative regulation of myofibroblast differentiation GO:1904761
Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast differentiation.
|
2 | P06400 (/ISS) P06400 (/ISS) |
|
Negative regulation of G1/S transition of mitotic cell cycle GO:2000134
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
|
2 | P06400 (/TAS) P06400 (/TAS) |
|
Positive regulation of transcription regulatory region DNA binding GO:2000679
Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding.
|
2 | P06400 (/IDA) P06400 (/IDA) |
|
Negative regulation of apoptotic signaling pathway GO:2001234
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
|
2 | P06400 (/ISS) P06400 (/ISS) |
|
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
|
1 | P13405 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | P13405 (/IDA) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | P13405 (/IGI) |
|
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
|
1 | P13405 (/IGI) |
|
Tissue homeostasis GO:0001894
A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.
|
1 | P13405 (/IGI) |
|
Aortic valve morphogenesis GO:0003180
The process in which the structure of the aortic valve is generated and organized.
|
1 | P13405 (/IMP) |
|
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
|
1 | P13405 (/ISO) |
|
Cell cycle arrest GO:0007050
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
|
1 | P13405 (/IMP) |
|
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
1 | P33568 (/IEP) |
|
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
|
1 | P13405 (/ISO) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | P13405 (/IGI) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | P13405 (/IMP) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | P13405 (/ISO) |
|
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
|
1 | P13405 (/IMP) |
|
Sister chromatid biorientation GO:0031134
The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles.
|
1 | P13405 (/ISO) |
|
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | P13405 (/IMP) |
|
Maintenance of mitotic sister chromatid cohesion GO:0034088
The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle.
|
1 | P13405 (/ISO) |
|
Glial cell apoptotic process GO:0034349
Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system.
|
1 | P13405 (/IMP) |
|
Skeletal muscle cell differentiation GO:0035914
The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.
|
1 | P13405 (/IMP) |
|
Neuron maturation GO:0042551
A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state.
|
1 | P13405 (/IMP) |
|
Enucleate erythrocyte differentiation GO:0043353
The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus.
|
1 | P13405 (/IGI) |
|
Regulation of lipid kinase activity GO:0043550
Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid.
|
1 | P13405 (/ISO) |
|
Myoblast differentiation GO:0045445
The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.
|
1 | P13405 (/ISO) |
|
Positive regulation of macrophage differentiation GO:0045651
Any process that activates or increases the frequency, rate or extent of macrophage differentiation.
|
1 | P13405 (/IGI) |
|
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
|
1 | P13405 (/ISO) |
|
Positive regulation of mitotic metaphase/anaphase transition GO:0045842
Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
|
1 | P13405 (/ISO) |
|
Negative regulation of smoothened signaling pathway GO:0045879
Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
|
1 | P13405 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P13405 (/ISO) |
|
Negative regulation of mitotic cell cycle GO:0045930
Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
|
1 | P13405 (/IGI) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | P13405 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | P13405 (/IGI) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | P13405 (/IMP) |
|
Digestive tract development GO:0048565
The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.
|
1 | P13405 (/IMP) |
|
Cell morphogenesis involved in neuron differentiation GO:0048667
The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.
|
1 | P13405 (/IMP) |
|
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
|
1 | P13405 (/IMP) |
|
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
|
1 | P13405 (/IMP) |
|
Striated muscle cell differentiation GO:0051146
The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.
|
1 | P13405 (/IGI) |
|
Cell division GO:0051301
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
|
1 | P13405 (/IMP) |
|
Neuron apoptotic process GO:0051402
Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
|
1 | P13405 (/IMP) |
|
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
|
1 | P13405 (/IMP) |
|
Protein localization to chromosome, centromeric region GO:0071459
Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome.
|
1 | P13405 (/ISO) |
|
Cellular response to xenobiotic stimulus GO:0071466
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
|
1 | P13405 (/IMP) |
|
Negative regulation of protein serine/threonine kinase activity GO:0071901
Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
1 | P33568 (/IMP) |
|
Negative regulation of protein serine/threonine kinase activity GO:0071901
Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
1 | P13405 (/ISO) |
|
Regulation of cohesin loading GO:0071922
Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin.
|
1 | P13405 (/ISO) |
|
Negative regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0071930
Any process that stop, prevents or decreases transcription as part of the G1/S transition of the mitotic cell cycle.
|
1 | P13405 (/IGI) |
|
Hepatocyte apoptotic process GO:0097284
Any apoptotic process in a hepatocyte, the main structural component of the liver.
|
1 | P13405 (/IMP) |
|
Negative regulation of cold-induced thermogenesis GO:0120163
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
|
1 | P13405 (/IMP) |
|
Negative regulation of tau-protein kinase activity GO:1902948
Any process that stops, prevents or reduces the frequency, rate or extent of tau-protein kinase activity.
|
1 | P33568 (/IMP) |
|
Negative regulation of tau-protein kinase activity GO:1902948
Any process that stops, prevents or reduces the frequency, rate or extent of tau-protein kinase activity.
|
1 | P13405 (/ISO) |
|
Positive regulation of extracellular matrix organization GO:1903055
Any process that activates or increases the frequency, rate or extent of extracellular matrix organization.
|
1 | P13405 (/IMP) |
|
Negative regulation of hepatocyte apoptotic process GO:1903944
Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process.
|
1 | P33568 (/IMP) |
|
Negative regulation of hepatocyte apoptotic process GO:1903944
Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process.
|
1 | P13405 (/ISO) |
|
Positive regulation of collagen fibril organization GO:1904028
Any process that activates or increases the frequency, rate or extent of collagen fibril organization.
|
1 | P13405 (/IMP) |
|
Negative regulation of myofibroblast differentiation GO:1904761
Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast differentiation.
|
1 | P13405 (/IMP) |
|
Negative regulation of G1/S transition of mitotic cell cycle GO:2000134
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
|
1 | P13405 (/IMP) |
|
Positive regulation of transcription regulatory region DNA binding GO:2000679
Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding.
|
1 | P13405 (/ISO) |
|
Negative regulation of apoptotic signaling pathway GO:2001234
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
|
1 | P33568 (/IMP) |
|
Negative regulation of apoptotic signaling pathway GO:2001234
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
|
1 | P13405 (/ISO) |
There are 18 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | P06400 (/IDA) P06400 (/IDA) P13405 (/IDA) P33568 (/IDA) Q9YGE5 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | P13405 (/ISS) P33568 (/ISS) Q08E68 (/ISS) Q9BDQ3 (/ISS) |
|
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
|
4 | P13405 (/ISS) P33568 (/ISS) Q08E68 (/ISS) Q9BDQ3 (/ISS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | P06400 (/TAS) P06400 (/TAS) P13405 (/TAS) |
|
Rb-E2F complex GO:0035189
A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression.
|
3 | P06400 (/IDA) P06400 (/IDA) P13405 (/IDA) |
|
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
|
2 | P06400 (/TAS) P06400 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P06400 (/NAS) P06400 (/NAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | P06400 (/IDA) P06400 (/IDA) |
|
SWI/SNF complex GO:0016514
A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof.
|
2 | P06400 (/TAS) P06400 (/TAS) |
|
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
|
2 | P06400 (/IDA) P06400 (/IDA) |
|
Rb-E2F complex GO:0035189
A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression.
|
2 | P06400 (/TAS) P06400 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P13405 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | P13405 (/ISO) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
1 | P13405 (/IDA) |
|
Spindle GO:0005819
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
|
1 | P13405 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9YGE5 (/IDA) |
|
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
|
1 | P13405 (/ISO) |
|
Rb-E2F complex GO:0035189
A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression.
|
1 | P13405 (/ISO) |