The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Calponin-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 51: Abnormal spindle-like microcephaly-associated prot...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
3 Q8CJ27 (/IDA) Q9VC45 (/IDA) Q9VC45 (/IDA)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
2 Q9VC45 (/IDA) Q9VC45 (/IDA)
Myosin light chain binding GO:0032027
Interacting selectively and non-covalently with a light chain of a myosin complex.
2 Q9VC45 (/IPI) Q9VC45 (/IPI)

There are 37 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Spindle organization GO:0007051
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.
3 Q8IZT6 (/IMP) Q9VC45 (/IMP) Q9VC45 (/IMP)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
3 Q8CJ27 (/IMP) Q9VC45 (/IMP) Q9VC45 (/IMP)
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
2 Q9VC45 (/IMP) Q9VC45 (/IMP)
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
2 Q9VC45 (/IDA) Q9VC45 (/IDA)
Mitotic spindle organization GO:0007052
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
2 Q9VC45 (/IMP) Q9VC45 (/IMP)
Nuclear migration GO:0007097
The directed movement of the nucleus to a specific location within a cell.
2 Q9VC45 (/IMP) Q9VC45 (/IMP)
Cystoblast division GO:0007282
Any of the rounds of incomplete mitosis undergone by a cystoblast to form a cyst of interconnected cells.
2 Q9VC45 (/IMP) Q9VC45 (/IMP)
Actin filament reorganization involved in cell cycle GO:0030037
The cell cycle process in which rearrangement of the spatial distribution of actin filaments and associated proteins occurs.
2 Q9VC45 (/IMP) Q9VC45 (/IMP)
Germarium-derived oocyte differentiation GO:0030706
The process in which one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte. An example of this process can be found in Drosophila melanogaster.
2 Q9VC45 (/IMP) Q9VC45 (/IMP)
Ovarian fusome organization GO:0030723
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions.
2 Q9VC45 (/IMP) Q9VC45 (/IMP)
Astral microtubule nucleation GO:0030954
The 'de novo' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule.
2 Q9VC45 (/IMP) Q9VC45 (/IMP)
Female germ-line stem cell asymmetric division GO:0048132
The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes.
2 Q9VC45 (/IMP) Q9VC45 (/IMP)
Brain morphogenesis GO:0048854
The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
2 Q9VC45 (/IMP) Q9VC45 (/IMP)
Establishment of meiotic spindle localization GO:0051295
The cell cycle process in which the directed movement of the meiotic spindle to a specific location in the cell occurs.
2 Q9VC45 (/IMP) Q9VC45 (/IMP)
Kinetochore organization GO:0051383
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
2 Q9VC45 (/IMP) Q9VC45 (/IMP)
Centrosome localization GO:0051642
Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell.
2 Q9VC45 (/IMP) Q9VC45 (/IMP)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
1 A0A0R4INR1 (/IMP)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
1 Q8CJ27 (/IGI)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
1 Q8CJ27 (/IMP)
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
1 Q8CJ27 (/IGI)
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
1 Q8CJ27 (/IMP)
Spindle organization GO:0007051
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.
1 Q8CJ27 (/ISO)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 Q8CJ27 (/IMP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 Q8CJ27 (/IMP)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
1 Q8CJ27 (/IMP)
Forebrain neuroblast division GO:0021873
The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast.
1 Q8CJ27 (/IMP)
Cerebral cortex development GO:0021987
The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.
1 Q8CJ27 (/IMP)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
1 Q8CJ27 (/IMP)
Negative regulation of asymmetric cell division GO:0045769
Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division.
1 Q8CJ27 (/IMP)
Developmental growth GO:0048589
The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
1 Q8CJ27 (/IMP)
Regulation of meiotic cell cycle GO:0051445
Any process that modulates the rate or extent of progression through the meiotic cell cycle.
1 Q8CJ27 (/IMP)
Spindle localization GO:0051653
Any process in which is the spindle is transported to, and/or maintained in, a specific location.
1 Q8IZT6 (/IMP)
Spindle localization GO:0051653
Any process in which is the spindle is transported to, and/or maintained in, a specific location.
1 Q8CJ27 (/ISO)
Maintenance of centrosome location GO:0051661
Any process in which a centrosome is maintained in a specific location within a cell and prevented from moving elsewhere.
1 Q8CJ27 (/IMP)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 Q8CJ27 (/IGI)
Spindle assembly involved in meiosis GO:0090306
The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis.
1 Q8CJ27 (/IMP)
Neuronal stem cell population maintenance GO:0097150
Any process in by an organism or tissue maintains a population of neuronal stem cells.
1 Q8CJ27 (/IMP)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Spindle pole GO:0000922
Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
3 Q8CJ27 (/IDA) Q9VC45 (/IDA) Q9VC45 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
3 D3ZZQ1 (/IDA) Q9VC45 (/IDA) Q9VC45 (/IDA)
Mitotic spindle pole GO:0097431
Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
3 D3ZZQ1 (/IDA) Q8CJ27 (/IDA) Q8IZT6 (/IDA)
Microtubule organizing center GO:0005815
An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
2 Q9VC45 (/IDA) Q9VC45 (/IDA)
Microtubule associated complex GO:0005875
Any multimeric complex connected to a microtubule.
2 Q9VC45 (/IDA) Q9VC45 (/IDA)
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
2 D3ZZQ1 (/IDA) Q8CJ27 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8IZT6 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8CJ27 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8CJ27 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 Q8CJ27 (/ISO)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
1 Q8CJ27 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 D3ZZQ1 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q8CJ27 (/ISO)
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
1 Q8CJ27 (/ISO)
Microtubule minus-end GO:0036449
The end of a microtubule that does not preferentially grow (polymerize).
1 Q8IZT6 (/IDA)
Microtubule minus-end GO:0036449
The end of a microtubule that does not preferentially grow (polymerize).
1 Q8CJ27 (/ISO)
Meiotic spindle GO:0072687
A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle.
1 Q8CJ27 (/IDA)
Mitotic spindle pole GO:0097431
Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
1 Q8CJ27 (/ISO)