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CATH Superfamily 1.10.4100.10

2-methylcitrate dehydratase PrpD

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
2-methylcitrate dehydratase PrpD
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: 2-methylcitrate dehydratase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-methylcitrate dehydratase. [EC: 4.2.1.79]
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3- tricarboxylate + H(2)O.
  • Specific for (2S,3S)-methylcitrate, showing no activity with (2R,3S)- methylcitrate.
  • Can also use cis-aconitate as a substrate but more slowly.
  • Both this enzyme and EC 4.2.1.3 are required to complete the isomerization of (2S,3S)-methylcitrate to (2R,3S)-2-methylisocitrate.
 922 A0A024L6D7 A0A024L6D7 A0A024L6D7 A0A024L6D7 A0A024L6D7 A0A024L6D7 A0A024L6D7 A0A024L6D7 A0A024L6D7 A0A024L6D7
(912 more...)
Aconitate hydratase. [EC: 4.2.1.3]
Citrate = isocitrate.
  • Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate.
  • The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate.
  • Cis-aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3- tricarboxylate.
  • Formerly EC 4.2.1.4.
 837 A0A024L6D7 A0A024L6D7 A0A024L6D7 A0A024L6D7 A0A024L6D7 A0A024L6D7 A0A024L6D7 A0A024L6D7 A0A024L6D7 A0A024L6D7
(827 more...)