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CATH Superfamily 1.10.390.10

Neutral Protease Domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Neutral Protease Domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: Thermolysin

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Bacillolysin. [EC: 3.4.24.28]
Similar, but not identical, to that of thermolysin.
  • Variants of this enzyme have been found in species of Bacillus including B.subtilis, B.amyloliquefaciens, B.megaterium, B.mesentericus, B.cereus and B.stearothermophilus.
  • Belongs to peptidase family M4.
  • Formerly EC 3.4.24.4.
 441 A0A023P0D4 A0A023P0D4 A0A023P0D4 A0A023P0D4 A0A023P0D4 A0A023P0D4 A0A023P0D4 A0A023P0D4 A0A023P0D4 A0A023P0D4
(431 more...)
Pseudolysin. [EC: 3.4.24.26]
Hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic group at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects.
  • Causes tissue damage.
  • Belongs to peptidase family M4.
  • Formerly EC 3.4.24.4.
 61 A0A157TCV8 A0A157TCV8 A0A157TCV8 A0A157TCV8 A0A157TCV8 A0A1F0IBL7 A0A1F0IBL7 A0A1F0IBL7 A0A1F0IBL7 A0A1F0IBL7
(51 more...)