The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SLC41 divalent cation transporters, integral membrane domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Solute carrier family 41 member 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Divalent inorganic cation transmembrane transporter activity GO:0072509
Enables the transfer of inorganic cations with a valency of two from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.
17 D3ZM22 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS)
(7 more)
Magnesium ion transmembrane transporter activity GO:0015095
Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other.
16 Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA)
(6 more)
Transmembrane transporter activity GO:0022857
Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
16 Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA)
(6 more)
Transmembrane transporter activity GO:0022857
Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
16 Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP)
(6 more)
Magnesium:sodium antiporter activity GO:0061768
Catalysis of the reaction: Na+(in) + Mg2+(out) = Na+(out) + Mg2+(in).
16 Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP)
(6 more)
Divalent inorganic cation transmembrane transporter activity GO:0072509
Enables the transfer of inorganic cations with a valency of two from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.
3 Q8BJA2 (/IDA) Q8BYR8 (/IDA) Q8BYR8 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q96GZ6 (/IPI) Q96JW4 (/IPI)
Magnesium ion transmembrane transporter activity GO:0015095
Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other.
1 Q8BJA2 (/ISO)
Transmembrane transporter activity GO:0022857
Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
1 Q8BJA2 (/ISO)
Magnesium:sodium antiporter activity GO:0061768
Catalysis of the reaction: Na+(in) + Mg2+(out) = Na+(out) + Mg2+(in).
1 Q8BJA2 (/ISO)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to magnesium ion GO:0071286
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.
18 E1C334 (/IGI) E1C334 (/IGI) Q8IVJ1 (/IGI) Q8IVJ1 (/IGI) Q8IVJ1 (/IGI) Q8IVJ1 (/IGI) Q8IVJ1 (/IGI) Q8IVJ1 (/IGI) Q8IVJ1 (/IGI) Q8IVJ1 (/IGI)
(8 more)
Divalent metal ion transport GO:0070838
The directed movement of divalent metal cations, any metal ion with a +2 electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
17 D3ZM22 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS)
(7 more)
Cellular response to magnesium ion GO:0071286
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.
17 D3ZM22 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS)
(7 more)
Magnesium ion transmembrane transport GO:1903830
The directed movement of magnesium ion across a membrane.
17 Q8BJA2 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA)
(7 more)
Magnesium ion transmembrane transport GO:1903830
The directed movement of magnesium ion across a membrane.
17 D3ZM22 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS) Q8IVJ1 (/ISS)
(7 more)
Cellular magnesium ion homeostasis GO:0010961
Any process involved in the maintenance of an internal steady state of magnesium ions at the level of a cell.
16 Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP)
(6 more)
Magnesium ion transport GO:0015693
The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
16 Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA)
(6 more)
Magnesium ion transport GO:0015693
The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
16 Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP) Q8IVJ1 (/IMP)
(6 more)
Divalent metal ion transport GO:0070838
The directed movement of divalent metal cations, any metal ion with a +2 electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 Q8BJA2 (/IDA) Q8BYR8 (/IDA) Q8BYR8 (/IDA)
Cellular magnesium ion homeostasis GO:0010961
Any process involved in the maintenance of an internal steady state of magnesium ions at the level of a cell.
1 Q8BJA2 (/ISO)
Magnesium ion transport GO:0015693
The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q8BJA2 (/ISO)
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
1 E7EXX2 (/IMP)
Pronephros development GO:0048793
The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.
1 E7EXX2 (/IMP)
Cellular response to magnesium ion GO:0071286
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.
1 Q8BJA2 (/IDA)
Cellular response to magnesium ion GO:0071286
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.
1 Q8BJA2 (/ISO)
Magnesium ion transmembrane transport GO:1903830
The directed movement of magnesium ion across a membrane.
1 Q8BJA2 (/ISO)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
20 D6R9X6 (/IDA) D6RDB0 (/IDA) D6RHE3 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA)
(10 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
17 Q8IVJ1 (/TAS) Q8IVJ1 (/TAS) Q8IVJ1 (/TAS) Q8IVJ1 (/TAS) Q8IVJ1 (/TAS) Q8IVJ1 (/TAS) Q8IVJ1 (/TAS) Q8IVJ1 (/TAS) Q8IVJ1 (/TAS) Q8IVJ1 (/TAS)
(7 more)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
16 Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA)
(6 more)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
16 Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA) Q8IVJ1 (/IDA)
(6 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q8BJA2 (/ISO) Q921R8 (/ISO)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 Q8BJA2 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q8BJA2 (/ISO)