The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Tetracycline Repressor, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: HTH-type transcriptional regulator AcrR

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
205 P0ACS9 (/ISS) P0ACS9 (/ISS) P0ACS9 (/ISS) P0ACS9 (/ISS) P0ACS9 (/ISS) P0ACS9 (/ISS) P0ACS9 (/ISS) P0ACS9 (/ISS) P0ACS9 (/ISS) P0ACS9 (/ISS)
(195 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
145 P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA)
(135 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
145 P0ACS9 (/IPI) P0ACS9 (/IPI) P0ACS9 (/IPI) P0ACS9 (/IPI) P0ACS9 (/IPI) P0ACS9 (/IPI) P0ACS9 (/IPI) P0ACS9 (/IPI) P0ACS9 (/IPI) P0ACS9 (/IPI)
(135 more)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
145 P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA)
(135 more)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
145 P0ACS9 (/ISS) P0ACS9 (/ISS) P0ACS9 (/ISS) P0ACS9 (/ISS) P0ACS9 (/ISS) P0ACS9 (/ISS) P0ACS9 (/ISS) P0ACS9 (/ISS) P0ACS9 (/ISS) P0ACS9 (/ISS)
(135 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
145 P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA)
(135 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
50 P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP)
(40 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
10 Q9HY46 (/IDA) Q9HY46 (/IDA) Q9HY46 (/IDA) Q9HY46 (/IDA) Q9HY46 (/IDA) Q9HY46 (/IDA) Q9HY46 (/IDA) Q9HY46 (/IDA) Q9HY46 (/IDA) Q9HY46 (/IDA)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
10 Q9HY46 (/IDA) Q9HY46 (/IDA) Q9HY46 (/IDA) Q9HY46 (/IDA) Q9HY46 (/IDA) Q9HY46 (/IDA) Q9HY46 (/IDA) Q9HY46 (/IDA) Q9HY46 (/IDA) Q9HY46 (/IDA)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
1 Q9AIU0 (/IDA)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
1 Q9AIU0 (/IMP)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
1 Q9AIU0 (/IPI)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
1 Q9AIU0 (/IDA)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
1 Q9AIU0 (/IMP)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
1 Q9AIU0 (/IPI)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
145 P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA)
(135 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
145 P0ACS9 (/IEP) P0ACS9 (/IEP) P0ACS9 (/IEP) P0ACS9 (/IEP) P0ACS9 (/IEP) P0ACS9 (/IEP) P0ACS9 (/IEP) P0ACS9 (/IEP) P0ACS9 (/IEP) P0ACS9 (/IEP)
(135 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
145 P0ACS9 (/IMP) P0ACS9 (/IMP) P0ACS9 (/IMP) P0ACS9 (/IMP) P0ACS9 (/IMP) P0ACS9 (/IMP) P0ACS9 (/IMP) P0ACS9 (/IMP) P0ACS9 (/IMP) P0ACS9 (/IMP)
(135 more)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
145 P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA)
(135 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
145 P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA) P0ACS9 (/IDA)
(135 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
60 P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP)
(50 more)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
50 P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP) P0ACT2 (/IMP)
(40 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
50 P0ACT2 (/ISS) P0ACT2 (/ISS) P0ACT2 (/ISS) P0ACT2 (/ISS) P0ACT2 (/ISS) P0ACT2 (/ISS) P0ACT2 (/ISS) P0ACT2 (/ISS) P0ACT2 (/ISS) P0ACT2 (/ISS)
(40 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
10 Q87X86 (/ISS) Q87X86 (/ISS) Q87X86 (/ISS) Q87X86 (/ISS) Q87X86 (/ISS) Q87X86 (/ISS) Q87X86 (/ISS) Q87X86 (/ISS) Q87X86 (/ISS) Q87X86 (/ISS)
Negative regulation of transporter activity GO:0032410
Any process that stops or reduces the activity of a transporter.
10 Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP)
Negative regulation of transmembrane transport GO:0034763
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.
10 Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP)
Negative regulation of transport GO:0051051
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
10 Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP) Q9HY46 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
1 Q9AIU0 (/IDA)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
1 Q9AIU0 (/IMP)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
1 Q9AIU0 (/IPI)