The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Sec63 N-terminal domain-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: SEC63 homolog, protein translocation regulator

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
8 Q9UGP8 (/HDA) Q9UGP8 (/HDA) Q9UGP8 (/HDA) Q9UGP8 (/HDA) Q9UGP8 (/HDA) Q9UGP8 (/HDA) Q9UGP8 (/HDA) Q9UGP8 (/HDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 Q9UGP8 (/IPI) Q9UGP8 (/IPI) Q9UGP8 (/IPI) Q9UGP8 (/IPI) Q9UGP8 (/IPI) Q9UGP8 (/IPI) Q9UGP8 (/IPI) Q9UGP8 (/IPI)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
8 Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
SRP-dependent cotranslational protein targeting to membrane GO:0006614
The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
9 Q8VHE0 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP)
Posttranslational protein targeting to endoplasmic reticulum membrane GO:0006620
The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane.
9 Q8VHE0 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP)
Protein targeting to membrane GO:0006612
The process of directing proteins towards a membrane, usually using signals contained within the protein.
8 Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS)
Posttranslational protein targeting to membrane, translocation GO:0031204
The process in which a protein translocates through the ER membrane posttranslationally.
8 Q9UGP8 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP) Q9UGP8 (/IMP)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
3 F1QGI2 (/IMP) Q6DGY6 (/IMP) Q8VHE0 (/IMP)
Endoplasmic reticulum unfolded protein response GO:0030968
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
2 F1QGI2 (/IMP) Q6DGY6 (/IMP)
Posttranslational protein targeting to membrane, translocation GO:0031204
The process in which a protein translocates through the ER membrane posttranslationally.
2 Q5R660 (/ISS) Q8VHE0 (/ISS)
Myelination GO:0042552
The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
2 F1QGI2 (/IMP) Q6DGY6 (/IMP)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
1 Q8VHE0 (/IGI)
SRP-dependent cotranslational protein targeting to membrane GO:0006614
The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
1 Q8VHE0 (/ISO)
Posttranslational protein targeting to endoplasmic reticulum membrane GO:0006620
The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane.
1 Q8VHE0 (/ISO)
Nitrogen compound metabolic process GO:0006807
The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
1 Q8VHE0 (/IGI)
Multicellular organism aging GO:0010259
An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700).
1 Q8VHE0 (/IMP)
Posttranslational protein targeting to membrane, translocation GO:0031204
The process in which a protein translocates through the ER membrane posttranslationally.
1 Q8VHE0 (/ISO)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
16 A0A0S2Z5M1 (/IDA) A0A0S2Z5M1 (/IDA) A0A0S2Z5M1 (/IDA) A0A0S2Z5M1 (/IDA) A0A0S2Z5M1 (/IDA) A0A0S2Z5M1 (/IDA) A0A0S2Z5M1 (/IDA) A0A0S2Z5M1 (/IDA) Q9UGP8 (/IDA) Q9UGP8 (/IDA)
(6 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
8 Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
8 Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS) Q9UGP8 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
8 Q9UGP8 (/IDA) Q9UGP8 (/IDA) Q9UGP8 (/IDA) Q9UGP8 (/IDA) Q9UGP8 (/IDA) Q9UGP8 (/IDA) Q9UGP8 (/IDA) Q9UGP8 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q8VHE0 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q8VHE0 (/ISO)