The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
DNA Polymerase alpha, zinc finger
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: DNA Polymerase alpha, zinc finger

Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. There are many superfamilies of Znf motifs, varying in both sequence and structure suggesting that this motifs are stable scaffolds that have evolved specialised functions.

Structural domains comprising this superfamily share the structure of the DNA Polymerase alpha zinc finger domain which a helix-turn-helix motif in contrast to other zinc finger domains that show anti-parallel sheet and helix conformation. Zinc binding occurs due to the presence of four cysteine residues positioned to bind the metal centre in a tetrahedral coordination geometry. The function of this domain is uncertain although it has been suggested that this zinc finger motif may be an essential part of the DNA binding domain PMID:14499601.

GO Diversity

Unique GO annotations
56 Unique GO terms

EC Diversity

Unique EC annotations
2 Unique EC terms

Species Diversity

Unique species annotations
1317 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 8
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 2
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 21
Function
Unique EC: 2
Unique GO: 56
Taxonomy
Unique Species: 1317