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CATH Superfamily 1.10.290.10

Topoisomerase I, domain 4

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Topoisomerase I, domain 4
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
DNA topoisomerase. [EC: 5.6.2.2]
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
  • These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.3.
  • Formerly EC 5.99.1.2.
 383 A0A024L1A2 A0A024R1C2 A0A026V029 A0A028ABW5 A0A028E5I2 A0A069XLR7 A0A069XSL6 A0A070FGM9 A0A072ZS29 A0A073FV93
(373 more...)
DNA helicase. [EC: 3.6.4.12]
ATP + H(2)O = ADP + phosphate.
  • DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA.
  • Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15).
  • Some helicases unwind DNA as well as RNA (4,9).
  • May be identical with EC 3.6.4.13 (RNA helicase).
 26 A0A0E3GUZ3 A0A0E3MGP0 A0A101DBW6 D0KSB1 D0KTT3 G4FH87 I6TVD9 O29238 O51934 O58530
(16 more...)
DNA topoisomerase (ATP-hydrolyzing). [EC: 5.6.2.3]
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
  • The enzyme can introduce negative superhelical turns into double- stranded circular DNA.
  • One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2).
  • Formerly EC 5.99.1.3.
 26 A0A0E3GUZ3 A0A0E3MGP0 A0A101DBW6 D0KSB1 D0KTT3 G4FH87 I6TVD9 O29238 O51934 O58530
(16 more...)