The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: potassium voltage-gated channel subfamily G member...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Delayed rectifier potassium channel activity GO:0005251
Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.
14 D4AD53 (/IDA) Q8TAE7 (/IDA) Q8TAE7 (/IDA) Q8TAE7 (/IDA) Q8TDN1 (/IDA) Q8TDN1 (/IDA) Q96KK3 (/IDA) Q96KK3 (/IDA) Q9UIX4 (/IDA) Q9UIX4 (/IDA)
(4 more)
Delayed rectifier potassium channel activity GO:0005251
Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.
14 A2BDX4 (/ISS) A2BDX4 (/ISS) O35173 (/ISS) O88758 (/ISS) P59053 (/ISS) Q80XM3 (/ISS) Q8R523 (/ISS) Q8R523 (/ISS) Q9UIX4 (/ISS) Q9UIX4 (/ISS)
(4 more)
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
10 Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q96KK3 (/TAS) Q96KK3 (/TAS) Q9BQ31 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 H2KZE7 (/IPI) H2KZE8 (/IPI) Q7JPF0 (/IPI) Q8TAE7 (/IPI) Q8TAE7 (/IPI) Q8TAE7 (/IPI) Q96KK3 (/IPI) Q96KK3 (/IPI) Q9ULS6 (/IPI)
Ion channel inhibitor activity GO:0008200
Stops, prevents, or reduces the activity of an ion channel.
7 Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS)
Potassium channel activity GO:0005267
Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
6 Q9UIX4 (/NAS) Q9UIX4 (/NAS) Q9UIX4 (/NAS) Q9UIX4 (/NAS) Q9UIX4 (/NAS) Q9UIX4 (/NAS)
Voltage-gated potassium channel activity GO:0005249
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
5 H2KZE7 (/IDA) H2KZE8 (/IDA) Q7JPF0 (/IDA) Q8R523 (/IDA) Q8R523 (/IDA)
Delayed rectifier potassium channel activity GO:0005251
Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.
5 A2BDX4 (/ISO) A2BDX4 (/ISO) O35173 (/ISO) P59053 (/ISO) Q80XM3 (/ISO)
Potassium channel activity GO:0005267
Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
5 Q9H3M0 (/TAS) Q9H3M0 (/TAS) Q9H3M0 (/TAS) Q9H3M0 (/TAS) Q9H3M0 (/TAS)
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
3 E7F5Q8 (/IDA) Q96KK3 (/IDA) Q96KK3 (/IDA)
Delayed rectifier potassium channel activity GO:0005251
Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.
2 Q9BQ31 (/TAS) Q9UJ96 (/TAS)
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
2 O35173 (/ISS) O88758 (/ISS)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
2 Q8TDN1 (/IPI) Q8TDN1 (/IPI)
Inward rectifier potassium channel activity GO:0005242
Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
1 H2KZQ6 (/IDA)
Voltage-gated potassium channel activity GO:0005249
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
1 P59053 (/ISO)
Potassium channel activity GO:0005267
Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
1 P97557 (/IDA)
Potassium channel activity GO:0005267
Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
1 Q8BZN2 (/ISO)
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
1 O35173 (/ISO)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
1 Q80XM3 (/ISO)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of delayed rectifier potassium channel activity GO:1902259
Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity.
28 A2BDX4 (/ISS) A2BDX4 (/ISS) A4K2M4 (/ISS) A4K2N8 (/ISS) A4K2N8 (/ISS) A4K2N8 (/ISS) A4K2P6 (/ISS) A4K2P6 (/ISS) A4K2Q6 (/ISS) A4K2R3 (/ISS)
(18 more)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
20 A2BDX4 (/ISS) A2BDX4 (/ISS) A4K2M4 (/ISS) A4K2N8 (/ISS) A4K2N8 (/ISS) A4K2N8 (/ISS) A4K2P6 (/ISS) A4K2P6 (/ISS) A4K2Q6 (/ISS) A4K2R3 (/ISS)
(10 more)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
16 Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q96KK3 (/TAS) Q96KK3 (/TAS) Q9BQ31 (/TAS)
(6 more)
Potassium ion transmembrane transport GO:0071805
A process in which a potassium ion is transported from one side of a membrane to the other.
13 D4AD53 (/IDA) H2KZQ6 (/IDA) Q8TAE7 (/IDA) Q8TAE7 (/IDA) Q8TAE7 (/IDA) Q8TDN1 (/IDA) Q8TDN1 (/IDA) Q9UIX4 (/IDA) Q9UIX4 (/IDA) Q9UIX4 (/IDA)
(3 more)
Potassium ion transmembrane transport GO:0071805
A process in which a potassium ion is transported from one side of a membrane to the other.
10 A2BDX4 (/ISS) A2BDX4 (/ISS) P59053 (/ISS) Q80XM3 (/ISS) Q9UIX4 (/ISS) Q9UIX4 (/ISS) Q9UIX4 (/ISS) Q9UIX4 (/ISS) Q9UIX4 (/ISS) Q9UIX4 (/ISS)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
8 D4AD53 (/IDA) H2KZE7 (/IDA) H2KZE8 (/IDA) O35173 (/IDA) O35174 (/IDA) Q7JPF0 (/IDA) Q8R523 (/IDA) Q8R523 (/IDA)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
6 Q9UIX4 (/NAS) Q9UIX4 (/NAS) Q9UIX4 (/NAS) Q9UIX4 (/NAS) Q9UIX4 (/NAS) Q9UIX4 (/NAS)
Potassium ion transmembrane transport GO:0071805
A process in which a potassium ion is transported from one side of a membrane to the other.
4 A2BDX4 (/ISO) A2BDX4 (/ISO) P59053 (/ISO) Q80XM3 (/ISO)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 A2BDX4 (/ISO) A2BDX4 (/ISO) P59053 (/ISO)
Hyperosmotic response GO:0006972
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
3 H2KZE7 (/IMP) H2KZE8 (/IMP) Q7JPF0 (/IMP)
Mechanosensory behavior GO:0007638
Behavior that is dependent upon the sensation of a mechanical stimulus.
3 H2KZE7 (/IMP) H2KZE8 (/IMP) Q7JPF0 (/IMP)
Forward locomotion GO:0043056
Anterior movement of an organism, following the direction of the head of the animal.
3 H2KZE7 (/IMP) H2KZE8 (/IMP) Q7JPF0 (/IMP)
Regulation of chemotaxis GO:0050920
Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
3 H2KZE7 (/IMP) H2KZE8 (/IMP) Q7JPF0 (/IMP)
Regulation of delayed rectifier potassium channel activity GO:1902259
Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity.
3 D4AD53 (/IDA) O35173 (/IDA) O35174 (/IDA)
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
2 Q9BQ31 (/TAS) Q9UJ96 (/TAS)
Regulation of delayed rectifier potassium channel activity GO:1902259
Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity.
2 A2BDX4 (/ISO) A2BDX4 (/ISO)
Regulation of heart contraction GO:0008016
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
1 Q9UJ96 (/TAS)
Ventricular system development GO:0021591
The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus.
1 E7F5Q8 (/IMP)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
1 E7F5Q8 (/IMP)
Establishment or maintenance of neuroblast polarity GO:0045196
Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.
1 E7F5Q8 (/IMP)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
31 A2BDX4 (/ISS) A2BDX4 (/ISS) A4K2M4 (/ISS) A4K2N8 (/ISS) A4K2N8 (/ISS) A4K2N8 (/ISS) A4K2P6 (/ISS) A4K2P6 (/ISS) A4K2Q6 (/ISS) A4K2R3 (/ISS)
(21 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
29 Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q8TAE7 (/TAS) Q8TAE7 (/TAS) Q8TAE7 (/TAS)
(19 more)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
20 A4K2M4 (/ISS) A4K2N8 (/ISS) A4K2N8 (/ISS) A4K2N8 (/ISS) A4K2P6 (/ISS) A4K2P6 (/ISS) A4K2Q6 (/ISS) A4K2R3 (/ISS) A4K2S2 (/ISS) A4K2T1 (/ISS)
(10 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
17 D4AD53 (/IDA) O35173 (/IDA) O35174 (/IDA) Q8TAE7 (/IDA) Q8TAE7 (/IDA) Q8TAE7 (/IDA) Q8TDN1 (/IDA) Q8TDN1 (/IDA) Q96KK3 (/IDA) Q96KK3 (/IDA)
(7 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
7 Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS) Q6PIU1 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 A2BDX4 (/ISO) A2BDX4 (/ISO) O35173 (/ISO) P59053 (/ISO) Q80XM3 (/ISO) Q8BQZ8 (/ISO)
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
5 H2KZE7 (/IDA) H2KZE8 (/IDA) Q7JPF0 (/IDA) Q96KK3 (/IDA) Q96KK3 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
3 Q8TAE7 (/IDA) Q8TAE7 (/IDA) Q8TAE7 (/IDA)
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
2 O35173 (/ISS) O88758 (/ISS)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 O35173 (/IDA) O35174 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 P59053 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q9BQ31 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q8BQZ8 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9BQ31 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8BQZ8 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q95XV8 (/HDA)
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
1 H2KZQ6 (/IC)
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
1 O35173 (/ISO)
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
1 Q9UJ96 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q9UJ96 (/HDA)