The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 44: Voltage-dependent N-type calcium channel subunit a...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
4 G4SFC3 (/ISS) G5EFB0 (/ISS) Q86G45 (/ISS) Q8MPY5 (/ISS)
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
2 P91645 (/IDA) P91645 (/IDA)
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
2 P91645 (/IMP) P91645 (/IMP)
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
2 P91645 (/NAS) P91645 (/NAS)
High voltage-gated calcium channel activity GO:0008331
Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded.
2 P91645 (/IMP) P91645 (/IMP)
Low voltage-gated calcium channel activity GO:0008332
Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded.
2 P91645 (/IMP) P91645 (/IMP)

There are 38 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of neurotransmitter levels GO:0001505
Any process that modulates levels of neurotransmitter.
4 G4SFC3 (/IMP) G5EFB0 (/IMP) Q86G45 (/IMP) Q8MPY5 (/IMP)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
4 G4SFC3 (/IMP) G5EFB0 (/IMP) Q86G45 (/IMP) Q8MPY5 (/IMP)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
4 G4SFC3 (/IMP) G5EFB0 (/IMP) Q86G45 (/IMP) Q8MPY5 (/IMP)
Negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
4 G4SFC3 (/IGI) G5EFB0 (/IGI) Q86G45 (/IGI) Q8MPY5 (/IGI)
Determination of left/right asymmetry in nervous system GO:0035545
The establishment of the nervous system with respect to the left and right halves.
4 G4SFC3 (/IGI) G5EFB0 (/IGI) Q86G45 (/IGI) Q8MPY5 (/IGI)
Determination of left/right asymmetry in nervous system GO:0035545
The establishment of the nervous system with respect to the left and right halves.
4 G4SFC3 (/IMP) G5EFB0 (/IMP) Q86G45 (/IMP) Q8MPY5 (/IMP)
Response to starvation GO:0042594
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
4 G4SFC3 (/IMP) G5EFB0 (/IMP) Q86G45 (/IMP) Q8MPY5 (/IMP)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
4 G4SFC3 (/ISS) G5EFB0 (/ISS) Q86G45 (/ISS) Q8MPY5 (/ISS)
Regulation of heart rate GO:0002027
Any process that modulates the frequency or rate of heart contraction.
2 P91645 (/IMP) P91645 (/IMP)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P91645 (/IMP) P91645 (/IMP)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P91645 (/NAS) P91645 (/NAS)
Exocytosis GO:0006887
A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
2 P91645 (/IMP) P91645 (/IMP)
Autophagy GO:0006914
The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
2 P91645 (/IMP) P91645 (/IMP)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2 P91645 (/IDA) P91645 (/IDA)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2 P91645 (/IMP) P91645 (/IMP)
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
2 P91645 (/IMP) P91645 (/IMP)
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
2 P91645 (/NAS) P91645 (/NAS)
Courtship behavior GO:0007619
The behavioral interactions between organisms for the purpose of attracting sexual partners.
2 P91645 (/IMP) P91645 (/IMP)
Courtship behavior GO:0007619
The behavioral interactions between organisms for the purpose of attracting sexual partners.
2 P91645 (/NAS) P91645 (/NAS)
Visual behavior GO:0007632
The behavior of an organism in response to a visual stimulus.
2 P91645 (/NAS) P91645 (/NAS)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
2 P91645 (/IGI) P91645 (/IGI)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
2 P91645 (/IMP) P91645 (/IMP)
Positive regulation of calcium ion transport into cytosol GO:0010524
Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.
2 P91645 (/IMP) P91645 (/IMP)
Regulation of membrane potential in photoreceptor cell GO:0016057
Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon.
2 P91645 (/IGI) P91645 (/IGI)
Neuron remodeling GO:0016322
The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development.
2 P91645 (/IMP) P91645 (/IMP)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
2 P91645 (/IMP) P91645 (/IMP)
Epithelial fluid transport GO:0042045
The directed movement of fluid across epithelia.
2 P91645 (/IDA) P91645 (/IDA)
Epithelial fluid transport GO:0042045
The directed movement of fluid across epithelia.
2 P91645 (/IEP) P91645 (/IEP)
Male courtship behavior, veined wing generated song production GO:0045433
The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song.
2 P91645 (/IMP) P91645 (/IMP)
Male courtship behavior, veined wing generated song production GO:0045433
The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song.
2 P91645 (/NAS) P91645 (/NAS)
Male courtship behavior, veined wing generated song production GO:0045433
The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song.
2 P91645 (/TAS) P91645 (/TAS)
Positive regulation of synaptic growth at neuromuscular junction GO:0045887
Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction.
2 P91645 (/IMP) P91645 (/IMP)
Regulation of neurotransmitter secretion GO:0046928
Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.
2 P91645 (/IGI) P91645 (/IGI)
Detection of light stimulus involved in visual perception GO:0050908
The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.
2 P91645 (/IMP) P91645 (/IMP)
Neuron cellular homeostasis GO:0070050
The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.
2 P91645 (/IMP) P91645 (/IMP)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
2 P91645 (/IMP) P91645 (/IMP)
Autophagosome maturation GO:0097352
Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling.
2 P91645 (/IMP) P91645 (/IMP)
Positive regulation of adenylate cyclase activity GO:0045762
Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.
1 Q99244 (/ISS)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Presynaptic active zone membrane GO:0048787
The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters.
4 G4SFC3 (/IDA) G5EFB0 (/IDA) Q86G45 (/IDA) Q8MPY5 (/IDA)
Voltage-gated calcium channel complex GO:0005891
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
2 P91645 (/IGI) P91645 (/IGI)
Voltage-gated calcium channel complex GO:0005891
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
2 P91645 (/NAS) P91645 (/NAS)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
2 P91645 (/IDA) P91645 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 P91645 (/IDA) P91645 (/IDA)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
2 P91645 (/IMP) P91645 (/IMP)
Presynaptic active zone GO:0048786
A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.
2 P91645 (/IDA) P91645 (/IDA)