The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 32: Voltage-dependent T-type calcium channel subunit a...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Low voltage-gated calcium channel activity GO:0008332
Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded.
17 E9PWL1 (/IDA) O43497 (/IDA) O54898 (/IDA) Q27YN9 (/IDA) Q3UQG9 (/IDA) Q5SUF5 (/IDA) Q5SUF6 (/IDA) Q5SUF7 (/IDA) Q5SUF8 (/IDA) Q5SUF9 (/IDA)
(7 more)
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
15 E9PWL1 (/IDA) Q27YN9 (/IDA) Q3UQG9 (/IDA) Q5SUF5 (/IDA) Q5SUF6 (/IDA) Q5SUF7 (/IDA) Q5SUF8 (/IDA) Q5SUF9 (/IDA) Q5SUG0 (/IDA) Q5SUG1 (/IDA)
(5 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
15 E9PWL1 (/IPI) Q27YN9 (/IPI) Q3UQG9 (/IPI) Q5SUF5 (/IPI) Q5SUF6 (/IPI) Q5SUF7 (/IPI) Q5SUF8 (/IPI) Q5SUF9 (/IPI) Q5SUG0 (/IPI) Q5SUG1 (/IPI)
(5 more)
Low voltage-gated calcium channel activity GO:0008332
Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded.
15 E9PWL1 (/ISO) Q27YN9 (/ISO) Q3UQG9 (/ISO) Q5SUF5 (/ISO) Q5SUF6 (/ISO) Q5SUF7 (/ISO) Q5SUF8 (/ISO) Q5SUF9 (/ISO) Q5SUG0 (/ISO) Q5SUG1 (/ISO)
(5 more)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
15 E9PWL1 (/ISO) Q27YN9 (/ISO) Q3UQG9 (/ISO) Q5SUF5 (/ISO) Q5SUF6 (/ISO) Q5SUF7 (/ISO) Q5SUF8 (/ISO) Q5SUF9 (/ISO) Q5SUG0 (/ISO) Q5SUG1 (/ISO)
(5 more)
Voltage-gated calcium channel activity involved in AV node cell action potential GO:0086056
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
2 O43497 (/ISS) O54898 (/ISS)
Voltage-gated calcium channel activity involved SA node cell action potential GO:0086059
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
2 O43497 (/ISS) O54898 (/ISS)
Voltage-gated calcium channel activity involved in AV node cell action potential GO:0086056
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
1 Q5SUG4 (/IMP)
Voltage-gated calcium channel activity involved SA node cell action potential GO:0086059
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
1 Q5SUG4 (/IMP)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
1 O43497 (/IPI)

There are 39 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Action potential GO:0001508
A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.
15 E9PWL1 (/IMP) Q27YN9 (/IMP) Q3UQG9 (/IMP) Q5SUF5 (/IMP) Q5SUF6 (/IMP) Q5SUF7 (/IMP) Q5SUF8 (/IMP) Q5SUF9 (/IMP) Q5SUG0 (/IMP) Q5SUG1 (/IMP)
(5 more)
Regulation of heart rate GO:0002027
Any process that modulates the frequency or rate of heart contraction.
15 E9PWL1 (/IMP) Q27YN9 (/IMP) Q3UQG9 (/IMP) Q5SUF5 (/IMP) Q5SUF6 (/IMP) Q5SUF7 (/IMP) Q5SUF8 (/IMP) Q5SUF9 (/IMP) Q5SUG0 (/IMP) Q5SUG1 (/IMP)
(5 more)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
15 E9PWL1 (/ISO) Q27YN9 (/ISO) Q3UQG9 (/ISO) Q5SUF5 (/ISO) Q5SUF6 (/ISO) Q5SUF7 (/ISO) Q5SUF8 (/ISO) Q5SUF9 (/ISO) Q5SUG0 (/ISO) Q5SUG1 (/ISO)
(5 more)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
15 E9PWL1 (/IGI) Q27YN9 (/IGI) Q3UQG9 (/IGI) Q5SUF5 (/IGI) Q5SUF6 (/IGI) Q5SUF7 (/IGI) Q5SUF8 (/IGI) Q5SUF9 (/IGI) Q5SUG0 (/IGI) Q5SUG1 (/IGI)
(5 more)
Response to nickel cation GO:0010045
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus.
15 E9PWL1 (/IMP) Q27YN9 (/IMP) Q3UQG9 (/IMP) Q5SUF5 (/IMP) Q5SUF6 (/IMP) Q5SUF7 (/IMP) Q5SUF8 (/IMP) Q5SUF9 (/IMP) Q5SUG0 (/IMP) Q5SUG1 (/IMP)
(5 more)
Artery smooth muscle contraction GO:0014824
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart.
15 E9PWL1 (/ISO) Q27YN9 (/ISO) Q3UQG9 (/ISO) Q5SUF5 (/ISO) Q5SUF6 (/ISO) Q5SUF7 (/ISO) Q5SUF8 (/ISO) Q5SUF9 (/ISO) Q5SUG0 (/ISO) Q5SUG1 (/ISO)
(5 more)
Regulation of membrane potential GO:0042391
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
15 E9PWL1 (/ISO) Q27YN9 (/ISO) Q3UQG9 (/ISO) Q5SUF5 (/ISO) Q5SUF6 (/ISO) Q5SUF7 (/ISO) Q5SUF8 (/ISO) Q5SUF9 (/ISO) Q5SUG0 (/ISO) Q5SUG1 (/ISO)
(5 more)
Positive regulation of calcium ion-dependent exocytosis GO:0045956
Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis.
15 E9PWL1 (/ISO) Q27YN9 (/ISO) Q3UQG9 (/ISO) Q5SUF5 (/ISO) Q5SUF6 (/ISO) Q5SUF7 (/ISO) Q5SUF8 (/ISO) Q5SUF9 (/ISO) Q5SUG0 (/ISO) Q5SUG1 (/ISO)
(5 more)
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
15 E9PWL1 (/ISO) Q27YN9 (/ISO) Q3UQG9 (/ISO) Q5SUF5 (/ISO) Q5SUF6 (/ISO) Q5SUF7 (/ISO) Q5SUF8 (/ISO) Q5SUF9 (/ISO) Q5SUG0 (/ISO) Q5SUG1 (/ISO)
(5 more)
Regulation of atrial cardiac muscle cell membrane depolarization GO:0060371
Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte.
15 E9PWL1 (/IMP) Q27YN9 (/IMP) Q3UQG9 (/IMP) Q5SUF5 (/IMP) Q5SUF6 (/IMP) Q5SUF7 (/IMP) Q5SUF8 (/IMP) Q5SUF9 (/IMP) Q5SUG0 (/IMP) Q5SUG1 (/IMP)
(5 more)
Calcium ion transport into cytosol GO:0060402
The directed movement of calcium ions (Ca2+) into the cytosol.
15 E9PWL1 (/ISO) Q27YN9 (/ISO) Q3UQG9 (/ISO) Q5SUF5 (/ISO) Q5SUF6 (/ISO) Q5SUF7 (/ISO) Q5SUF8 (/ISO) Q5SUF9 (/ISO) Q5SUG0 (/ISO) Q5SUG1 (/ISO)
(5 more)
Calcium ion import GO:0070509
The directed movement of calcium ions into a cell or organelle.
15 E9PWL1 (/ISO) Q27YN9 (/ISO) Q3UQG9 (/ISO) Q5SUF5 (/ISO) Q5SUF6 (/ISO) Q5SUF7 (/ISO) Q5SUF8 (/ISO) Q5SUF9 (/ISO) Q5SUG0 (/ISO) Q5SUG1 (/ISO)
(5 more)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
15 E9PWL1 (/ISO) Q27YN9 (/ISO) Q3UQG9 (/ISO) Q5SUF5 (/ISO) Q5SUF6 (/ISO) Q5SUF7 (/ISO) Q5SUF8 (/ISO) Q5SUF9 (/ISO) Q5SUG0 (/ISO) Q5SUG1 (/ISO)
(5 more)
Calcium ion import GO:0070509
The directed movement of calcium ions into a cell or organelle.
2 O43497 (/IDA) O54898 (/IDA)
Cardiac muscle cell action potential involved in contraction GO:0086002
An action potential that occurs in a cardiac muscle cell and is involved in its contraction.
2 O43497 (/ISS) O54898 (/ISS)
SA node cell action potential GO:0086015
An action potential that occurs in a sinoatrial node cardiac muscle cell.
2 O43497 (/ISS) O54898 (/ISS)
AV node cell action potential GO:0086016
An action potential that occurs in an atrioventricular node cardiac muscle cell.
2 O43497 (/ISS) O54898 (/ISS)
SA node cell to atrial cardiac muscle cell signaling GO:0086018
Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte.
2 O43497 (/ISS) O54898 (/ISS)
AV node cell to bundle of His cell signaling GO:0086027
Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte.
2 O43497 (/ISS) O54898 (/ISS)
Membrane depolarization during AV node cell action potential GO:0086045
The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
2 O43497 (/ISS) O54898 (/ISS)
Membrane depolarization during SA node cell action potential GO:0086046
The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
2 O43497 (/ISS) O54898 (/ISS)
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
2 O43497 (/ISS) O54898 (/ISS)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
1 O54898 (/IMP)
Artery smooth muscle contraction GO:0014824
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart.
1 O54898 (/IMP)
Regulation of membrane potential GO:0042391
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
1 O43497 (/IDA)
Positive regulation of calcium ion-dependent exocytosis GO:0045956
Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis.
1 O54898 (/IMP)
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 O54898 (/IMP)
Calcium ion transport into cytosol GO:0060402
The directed movement of calcium ions (Ca2+) into the cytosol.
1 O54898 (/IDA)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 O43497 (/IDA)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 Q5SUG4 (/IMP)
Cellular response to dexamethasone stimulus GO:0071549
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
1 O54898 (/IEP)
Cardiac muscle cell action potential involved in contraction GO:0086002
An action potential that occurs in a cardiac muscle cell and is involved in its contraction.
1 Q5SUG4 (/IMP)
SA node cell action potential GO:0086015
An action potential that occurs in a sinoatrial node cardiac muscle cell.
1 Q5SUG4 (/IMP)
AV node cell action potential GO:0086016
An action potential that occurs in an atrioventricular node cardiac muscle cell.
1 Q5SUG4 (/IMP)
SA node cell to atrial cardiac muscle cell signaling GO:0086018
Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte.
1 Q5SUG4 (/IMP)
AV node cell to bundle of His cell signaling GO:0086027
Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte.
1 Q5SUG4 (/IMP)
Membrane depolarization during AV node cell action potential GO:0086045
The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
1 Q5SUG4 (/IMP)
Membrane depolarization during SA node cell action potential GO:0086046
The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
1 Q5SUG4 (/IMP)
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
1 Q5SUG4 (/IMP)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
17 E9PWL1 (/IDA) O43497 (/IDA) O54898 (/IDA) Q27YN9 (/IDA) Q3UQG9 (/IDA) Q5SUF5 (/IDA) Q5SUF6 (/IDA) Q5SUF7 (/IDA) Q5SUF8 (/IDA) Q5SUF9 (/IDA)
(7 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
15 E9PWL1 (/ISO) Q27YN9 (/ISO) Q3UQG9 (/ISO) Q5SUF5 (/ISO) Q5SUF6 (/ISO) Q5SUF7 (/ISO) Q5SUF8 (/ISO) Q5SUF9 (/ISO) Q5SUG0 (/ISO) Q5SUG1 (/ISO)
(5 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
15 E9PWL1 (/ISO) Q27YN9 (/ISO) Q3UQG9 (/ISO) Q5SUF5 (/ISO) Q5SUF6 (/ISO) Q5SUF7 (/ISO) Q5SUF8 (/ISO) Q5SUF9 (/ISO) Q5SUG0 (/ISO) Q5SUG1 (/ISO)
(5 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
15 E9PWL1 (/ISO) Q27YN9 (/ISO) Q3UQG9 (/ISO) Q5SUF5 (/ISO) Q5SUF6 (/ISO) Q5SUF7 (/ISO) Q5SUF8 (/ISO) Q5SUF9 (/ISO) Q5SUG0 (/ISO) Q5SUG1 (/ISO)
(5 more)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
15 E9PWL1 (/ISO) Q27YN9 (/ISO) Q3UQG9 (/ISO) Q5SUF5 (/ISO) Q5SUF6 (/ISO) Q5SUF7 (/ISO) Q5SUF8 (/ISO) Q5SUF9 (/ISO) Q5SUG0 (/ISO) Q5SUG1 (/ISO)
(5 more)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
15 E9PWL1 (/ISO) Q27YN9 (/ISO) Q3UQG9 (/ISO) Q5SUF5 (/ISO) Q5SUF6 (/ISO) Q5SUF7 (/ISO) Q5SUF8 (/ISO) Q5SUF9 (/ISO) Q5SUG0 (/ISO) Q5SUG1 (/ISO)
(5 more)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
15 E9PWL1 (/ISO) Q27YN9 (/ISO) Q3UQG9 (/ISO) Q5SUF5 (/ISO) Q5SUF6 (/ISO) Q5SUF7 (/ISO) Q5SUF8 (/ISO) Q5SUF9 (/ISO) Q5SUG0 (/ISO) Q5SUG1 (/ISO)
(5 more)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
15 E9PWL1 (/ISO) Q27YN9 (/ISO) Q3UQG9 (/ISO) Q5SUF5 (/ISO) Q5SUF6 (/ISO) Q5SUF7 (/ISO) Q5SUF8 (/ISO) Q5SUF9 (/ISO) Q5SUG0 (/ISO) Q5SUG1 (/ISO)
(5 more)
Voltage-gated calcium channel complex GO:0005891
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
2 O43497 (/ISS) O54898 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O43497 (/IDA)
Voltage-gated calcium channel complex GO:0005891
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
1 O54898 (/IC)
Voltage-gated calcium channel complex GO:0005891
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
1 Q5SUG4 (/IDA)
Voltage-gated calcium channel complex GO:0005891
A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.
1 O43497 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 O54898 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 O54898 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 O54898 (/IDA)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
1 O54898 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 O54898 (/IDA)