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CATH Superfamily 1.10.287.540

Helix hairpin bin

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Helix hairpin bin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Pyrrolysine--tRNA(Pyl) ligase. [EC: 6.1.1.26]
ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl- tRNA(Pyl).
  • In organisms such as Methanosarcina barkeri that incorporate the modified amino acid pyrrolysine (Pyl) into certain methylamine methyltransferases, an unusual tRNA(Pyl), with a CUA anticodon, can be charged directly with pyrrolysine by this class II aminoacyl- -tRNA ligase.
  • Specific for pyrrolysine as substrate as it cannot be replaced by lysine or any of the other natural amino acids.
 16 A0A0E3LT83 A0A0E3PZI8 A0A0E3QHZ4 A0A0E3QQZ0 A0A0E3R5G6 A0A0E3RUJ0 A0A0E3RZQ6 A0A0E3WPC9 A0A0F8GPG2 A0A1D2WWG1
(6 more...)
23S rRNA (guanine(2535)-N(1))-methyltransferase. [EC: 2.1.1.209]
S-adenosyl-L-methionine + guanine(2535) in 23S rRNA = S-adenosyl-L- homocysteine + N(1)-methylguanine(2535) in 23S rRNA.
  • Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis.
  • To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (guanine(2535)-N(1))- methyltransferase and EC 2.1.1.208 whose actions confer avilamycin resistance to the RNA.
 1 Q9F5K5