The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Transcription factor IIA gamma subunit, alpha-helical domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Transcription factor IIA gamma subunit, alpha-helical domain

Structural domains comprising this superfamily share the structure of the alpha helical domain of the gamma subunit of the transcription factor IIA (TFIIA), which plays an important role in preinitiation complex (PIC) assembly in response to some transcriptional activators PMID:12972251.

Human and Drosophila TFIIA have three subunits: two large subunits, LN/alpha and LC/beta, derived from the same gene, and a small subunit, S/gamma. Yeast TFIIA on the other hand has two subunits: a large TOA1 subunit that shows sequence similarity to the N-terminal of LN/alpha and the C-terminal of LC/beta, and a small subunit, TOA2 that is highly homologous with S/gamma. This entry represents the alpha-helical domain found at the N-terminal of the gamma subunit of transcription factor TFIIA PMID:8610010.

GO Diversity

Unique GO annotations
21 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1290 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 7
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 7
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 3
Unique EC:
Unique GO: 21
Unique Species: 1290