The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"TPP helical domain
".
FunFam 1: 2-oxoglutarate dehydrogenase, mitochondrial isofor...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 12 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Oxoglutarate dehydrogenase (succinyl-transferring) activity GO:0004591
Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2.
|
14 |
Q02218 (/ISS)
Q02218 (/ISS)
Q02218 (/ISS)
Q02218 (/ISS)
Q02218 (/ISS)
Q02218 (/ISS)
Q02218 (/ISS)
Q148N0 (/ISS)
Q5RCB8 (/ISS)
Q5RCB8 (/ISS)
(4 more) |
Oxoglutarate dehydrogenase (succinyl-transferring) activity GO:0004591
Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2.
|
8 | Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q5XI78 (/IDA) |
Thiamine pyrophosphate binding GO:0030976
Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.
|
7 | Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) |
Thiamine pyrophosphate binding GO:0030976
Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.
|
7 | Q148N0 (/ISS) Q5RCB8 (/ISS) Q5RCB8 (/ISS) Q5XI78 (/ISS) Q60597 (/ISS) Q60HE2 (/ISS) Q6P6Z8 (/ISS) |
Oxoglutarate dehydrogenase (succinyl-transferring) activity GO:0004591
Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2.
|
1 | Q60597 (/ISO) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q9ULD0 (/IPI) |
Thiamine pyrophosphate binding GO:0030976
Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.
|
1 | Q60597 (/ISO) |
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
|
1 | Q5XI78 (/IPI) |
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
|
1 | Q60597 (/ISO) |
Oxoglutarate dehydrogenase (NAD+) activity GO:0034602
Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH.
|
1 | Q60597 (/IDA) |
Chaperone binding GO:0051087
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
|
1 | Q5XI78 (/IPI) |
Chaperone binding GO:0051087
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
|
1 | Q60597 (/ISO) |
There are 24 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Generation of precursor metabolites and energy GO:0006091
The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
|
12 |
Q02218 (/ISS)
Q02218 (/ISS)
Q02218 (/ISS)
Q02218 (/ISS)
Q02218 (/ISS)
Q02218 (/ISS)
Q02218 (/ISS)
Q5RCB8 (/ISS)
Q5RCB8 (/ISS)
Q5XI78 (/ISS)
(2 more) |
2-oxoglutarate metabolic process GO:0006103
The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
|
8 | Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q5XI78 (/IDA) |
Succinyl-CoA metabolic process GO:0006104
The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A.
|
8 | Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q5XI78 (/IDA) |
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
|
7 | Q02218 (/TAS) Q02218 (/TAS) Q02218 (/TAS) Q02218 (/TAS) Q02218 (/TAS) Q02218 (/TAS) Q02218 (/TAS) |
Lysine catabolic process GO:0006554
The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid.
|
7 | Q02218 (/TAS) Q02218 (/TAS) Q02218 (/TAS) Q02218 (/TAS) Q02218 (/TAS) Q02218 (/TAS) Q02218 (/TAS) |
Histone succinylation GO:0106077
The modification of a histone by the addition of an succinyl group.
|
7 | Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) |
Histone succinylation GO:0106077
The modification of a histone by the addition of an succinyl group.
|
7 | Q148N0 (/ISS) Q5RCB8 (/ISS) Q5RCB8 (/ISS) Q5XI78 (/ISS) Q60597 (/ISS) Q60HE2 (/ISS) Q6P6Z8 (/ISS) |
2-oxoglutarate metabolic process GO:0006103
The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
|
6 | Q148N0 (/ISS) Q5RCB8 (/ISS) Q5RCB8 (/ISS) Q60597 (/ISS) Q60HE2 (/ISS) Q6P6Z8 (/ISS) |
Succinyl-CoA metabolic process GO:0006104
The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A.
|
6 | Q148N0 (/ISS) Q5RCB8 (/ISS) Q5RCB8 (/ISS) Q60597 (/ISS) Q60HE2 (/ISS) Q6P6Z8 (/ISS) |
Heart contraction GO:0060047
The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.
|
5 | A0A0R4IP01 (/IGI) A0A2R8Q9W1 (/IGI) B8JI08 (/IGI) E7EZ05 (/IGI) F1Q5B8 (/IGI) |
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
|
1 | Q5XI78 (/IDA) |
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
|
1 | Q60597 (/ISO) |
2-oxoglutarate metabolic process GO:0006103
The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
|
1 | Q60597 (/ISO) |
Succinyl-CoA metabolic process GO:0006104
The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A.
|
1 | Q60597 (/ISO) |
NADH metabolic process GO:0006734
The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
|
1 | Q5XI78 (/IDA) |
NADH metabolic process GO:0006734
The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
|
1 | Q60597 (/ISO) |
Cerebellar cortex development GO:0021695
The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
|
1 | Q60597 (/IEP) |
Striatum development GO:0021756
The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati.
|
1 | Q60597 (/IEP) |
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
|
1 | Q60597 (/IEP) |
Thalamus development GO:0021794
The process in which the thalamus changes over time, from its initial formation to its mature state.
|
1 | Q60597 (/IEP) |
Pyramidal neuron development GO:0021860
The progression of a pyramidal neuron from its initial formation to its mature state.
|
1 | Q60597 (/IEP) |
Tangential migration from the subventricular zone to the olfactory bulb GO:0022028
The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration.
|
1 | Q60597 (/IEP) |
Olfactory bulb mitral cell layer development GO:0061034
The progression of the olfactory bulb mitral cell layer over time from its initial formation until its mature state. The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer.
|
1 | Q60597 (/IEP) |
Histone succinylation GO:0106077
The modification of a histone by the addition of an succinyl group.
|
1 | Q60597 (/ISO) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
25 |
A0A0D9SFS3 (/IDA)
E9PCR7 (/IDA)
E9PCR7 (/IDA)
E9PCR7 (/IDA)
E9PCR7 (/IDA)
E9PCR7 (/IDA)
E9PCR7 (/IDA)
E9PCR7 (/IDA)
E9PCR7 (/IDA)
E9PDF2 (/IDA)
(15 more) |
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
|
12 |
Q02218 (/ISS)
Q02218 (/ISS)
Q02218 (/ISS)
Q02218 (/ISS)
Q02218 (/ISS)
Q02218 (/ISS)
Q02218 (/ISS)
Q5RCB8 (/ISS)
Q5RCB8 (/ISS)
Q5XI78 (/ISS)
(2 more) |
Oxoglutarate dehydrogenase complex GO:0045252
A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).
|
8 | Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q5XI78 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) Q02218 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | Q148N0 (/ISS) Q5RCB8 (/ISS) Q5RCB8 (/ISS) Q5XI78 (/ISS) Q60597 (/ISS) Q60HE2 (/ISS) Q6P6Z8 (/ISS) |
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
7 | Q02218 (/TAS) Q02218 (/TAS) Q02218 (/TAS) Q02218 (/TAS) Q02218 (/TAS) Q02218 (/TAS) Q02218 (/TAS) |
Oxoglutarate dehydrogenase complex GO:0045252
A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).
|
6 | Q148N0 (/ISS) Q5RCB8 (/ISS) Q5RCB8 (/ISS) Q60597 (/ISS) Q60HE2 (/ISS) Q6P6Z8 (/ISS) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
5 | Q148N0 (/ISS) Q5RCB8 (/ISS) Q5RCB8 (/ISS) Q60HE2 (/ISS) Q6P6Z8 (/ISS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q60597 (/ISO) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q60597 (/HDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q60597 (/ISO) |
Oxoglutarate dehydrogenase complex GO:0045252
A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).
|
1 | Q60597 (/ISO) |