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CATH Superfamily 1.10.287.10

S15/NS1, RNA-binding

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
S15/NS1, RNA-binding
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 9 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Tryptophan--tRNA ligase. [EC: 6.1.1.2]
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl- tRNA(Trp).
    		 11 A0A024R6K8 A0A2J8SZZ4 A0A2R9C6X6 H2R965 P17248 P23381 P23612 P32921 Q5R4J1 Q5RCX9
    (1 more...)
    Glutamate--tRNA ligase. [EC: 6.1.1.17]
    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).
      		 11 P07814 P07814 P07814 P28668 P28668 Q7SIA2 Q7SIA2 Q7SIA2 Q8CGC7 Q8CGC7
      (1 more...)
      Ubiquitinyl hydrolase 1. [EC: 3.4.19.12]
      Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
      • Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides.
      • Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals.
      • Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde).
      • Belongs to peptidase family C12.
      		 11 A0A178VLA5 O17850 O35815 P54252 Q546X9 Q60XN1 Q8LQ36 Q9CVD2 Q9H3M9 Q9M391
      (1 more...)
      Proline--tRNA ligase. [EC: 6.1.1.15]
      ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).
        		 11 P07814 P07814 P07814 P28668 P28668 Q7SIA2 Q7SIA2 Q7SIA2 Q8CGC7 Q8CGC7
        (1 more...)
        Protein-serine/threonine phosphatase. [EC: 3.1.3.16]
        [a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
        • A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48).
        • The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).
        		 10 A0A0L8VJ76 A6ZMZ3 C7GTM2 C8ZFE4 N1NXR6 Q03254 Q7TSG2 Q95QG8 Q9P376 Q9Y5B0
        Glycine--tRNA ligase. [EC: 6.1.1.14]
        ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).
          		 6 O23627 P41250 Q04451 Q10039 Q5RBL1 Q9CZD3
          Histidine--tRNA ligase. [EC: 6.1.1.21]
          ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).
            		 6 O43011 P07178 P12081 Q2KI84 Q5R4R2 Q61035
            Methionine--tRNA ligase. [EC: 6.1.1.10]
            ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl- tRNA(Met).
            • In those organisms producing N-formylmethionyl-tRNA(fMet) for translation initiation, this enzyme also recognizes the initiator tRNA(fMet) and catalyzes the formation of L-methionyl-tRNA(fMet), the substrate for EC 2.1.2.9.
            		 4 P56192 Q2T9L8 Q68FL6 Q6PF21
            Asparagine--tRNA ligase. [EC: 6.1.1.22]
            ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl- tRNA(Asn).
              		 1 Q9SW96