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CATH Superfamily 1.10.260.40

lambda repressor-like DNA-binding domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
lambda repressor-like DNA-binding domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: HTH-type transcriptional repressor PurR

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 277 A0A0E2J8L1 (/IDA) A0A0E2J8L1 (/IDA) A8AWB2 (/IDA) A8AWB2 (/IDA) F9UQH6 (/IDA) F9UQH6 (/IDA) F9UQH6 (/IDA) F9UQH6 (/IDA) F9UQH6 (/IDA) F9UQH6 (/IDA)
(267 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 275 P03024 (/IPI) P03024 (/IPI) P03024 (/IPI) P03024 (/IPI) P03024 (/IPI) P03024 (/IPI) P03024 (/IPI) P03024 (/IPI) P03024 (/IPI) P03024 (/IPI)
(265 more)
Guanine binding GO:0002057
Interacting selectively and non-covalently with guanine.
 148 P0ACP7 (/IDA) P0ACP7 (/IDA) P0ACP7 (/IDA) P0ACP7 (/IDA) P0ACP7 (/IDA) P0ACP7 (/IDA) P0ACP7 (/IDA) P0ACP7 (/IDA) P0ACP7 (/IDA) P0ACP7 (/IDA)
(138 more)
Bacterial-type proximal promoter sequence-specific DNA binding GO:0000986
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a bacterial gene (or cistron, or operon). The proximal promoter is in cis with and relatively close to the core promoter.
 106 P03023 (/IDA) P03023 (/IDA) P03023 (/IDA) P03023 (/IDA) P03023 (/IDA) P03023 (/IDA) P03023 (/IDA) P03023 (/IDA) P03023 (/IDA) P03023 (/IDA)
(96 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 94 A0A0E2J8L1 (/IDA) A0A0E2J8L1 (/IDA) A8AWB2 (/IDA) A8AWB2 (/IDA) F9UQH6 (/IDA) F9UQH6 (/IDA) F9UQH6 (/IDA) F9UQH6 (/IDA) F9UQH6 (/IDA) F9UQH6 (/IDA)
(84 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 85 P0ACQ0 (/IDA) P0ACQ0 (/IDA) P0ACQ0 (/IDA) P0ACQ0 (/IDA) P0ACQ0 (/IDA) P0ACQ0 (/IDA) P0ACQ0 (/IDA) P0ACQ0 (/IDA) P0ACQ0 (/IDA) P0ACQ0 (/IDA)
(75 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 71 A0A0E2J8L1 (/IMP) A0A0E2J8L1 (/IMP) A8AWB2 (/IMP) A8AWB2 (/IMP) F9UQH6 (/IMP) F9UQH6 (/IMP) F9UQH6 (/IMP) F9UQH6 (/IMP) F9UQH6 (/IMP) F9UQH6 (/IMP)
(61 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 67 P03023 (/IPI) P03023 (/IPI) P03023 (/IPI) P03023 (/IPI) P03023 (/IPI) P03023 (/IPI) P03023 (/IPI) P03023 (/IPI) P03023 (/IPI) P03023 (/IPI)
(57 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 61 A0A0E2J8L1 (/IMP) A0A0E2J8L1 (/IMP) A8AWB2 (/IMP) A8AWB2 (/IMP) F9UQH6 (/IMP) F9UQH6 (/IMP) F9UQH6 (/IMP) F9UQH6 (/IMP) F9UQH6 (/IMP) F9UQH6 (/IMP)
(51 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
 46 P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA)
(36 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
 41 Q9KLR8 (/ISS) Q9KLR8 (/ISS) Q9KLR8 (/ISS) Q9KLR8 (/ISS) Q9KLR8 (/ISS) Q9KLR8 (/ISS) Q9KLR8 (/ISS) Q9KN33 (/ISS) Q9KN33 (/ISS) Q9KN33 (/ISS)
(31 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 30 F9UQH6 (/IPI) F9UQH6 (/IPI) F9UQH6 (/IPI) F9UQH6 (/IPI) F9UQH6 (/IPI) F9UQH6 (/IPI) P25144 (/IPI) P25144 (/IPI) P25144 (/IPI) P25144 (/IPI)
(20 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 30 F9UQH6 (/IPI) F9UQH6 (/IPI) F9UQH6 (/IPI) F9UQH6 (/IPI) F9UQH6 (/IPI) F9UQH6 (/IPI) P25144 (/IPI) P25144 (/IPI) P25144 (/IPI) P25144 (/IPI)
(20 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 10 P25144 (/IMP) P25144 (/IMP) P25144 (/IMP) P25144 (/IMP) P25144 (/IMP) P25144 (/IMP) P25144 (/IMP) P25144 (/IMP) P25144 (/IMP) P25144 (/IMP)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 10 P25144 (/IPI) P25144 (/IPI) P25144 (/IPI) P25144 (/IPI) P25144 (/IPI) P25144 (/IPI) P25144 (/IPI) P25144 (/IPI) P25144 (/IPI) P25144 (/IPI)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 3 Q9A3Y5 (/EXP) Q9A3Y5 (/EXP) Q9A3Y5 (/EXP)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 3 Q9A3Y5 (/EXP) Q9A3Y5 (/EXP) Q9A3Y5 (/EXP)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 183 P03023 (/IMP) P03023 (/IMP) P03023 (/IMP) P03023 (/IMP) P03023 (/IMP) P03023 (/IMP) P03023 (/IMP) P03023 (/IMP) P03023 (/IMP) P03023 (/IMP)
(173 more)
Negative regulation of purine nucleotide biosynthetic process GO:1900372
Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide biosynthetic processes.
 148 P0ACP7 (/IMP) P0ACP7 (/IMP) P0ACP7 (/IMP) P0ACP7 (/IMP) P0ACP7 (/IMP) P0ACP7 (/IMP) P0ACP7 (/IMP) P0ACP7 (/IMP) P0ACP7 (/IMP) P0ACP7 (/IMP)
(138 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
 71 P0ACQ0 (/IEP) P0ACQ0 (/IEP) P0ACQ0 (/IEP) P0ACQ0 (/IEP) P0ACQ0 (/IEP) P0ACQ0 (/IEP) P0ACQ0 (/IEP) P0ACQ0 (/IEP) P0ACQ0 (/IEP) P0ACQ0 (/IEP)
(61 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
 53 Q81KR1 (/ISS) Q81KR1 (/ISS) Q81KR1 (/ISS) Q81KR1 (/ISS) Q81KR1 (/ISS) Q81KR1 (/ISS) Q81KR1 (/ISS) Q81KR1 (/ISS) Q81KR1 (/ISS) Q81KR1 (/ISS)
(43 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 50 H7C6V6 (/IDA) H7C6V6 (/IDA) H7C6V6 (/IDA) H7C6V6 (/IDA) H7C6V6 (/IDA) H7C6V6 (/IDA) H7C6V6 (/IDA) H7C6V6 (/IDA) H7C6V6 (/IDA) H7C6V6 (/IDA)
(40 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
 46 P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA)
(36 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 45 F9UQH6 (/IEP) F9UQH6 (/IEP) F9UQH6 (/IEP) F9UQH6 (/IEP) F9UQH6 (/IEP) F9UQH6 (/IEP) N0CDN9 (/IEP) P25144 (/IEP) P25144 (/IEP) P25144 (/IEP)
(35 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
 32 P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA) P03024 (/IDA)
(22 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
 29 P77615 (/ISS) P77615 (/ISS) P77615 (/ISS) P77615 (/ISS) P77615 (/ISS) P77615 (/ISS) P77615 (/ISS) P77615 (/ISS) P77615 (/ISS) P77615 (/ISS)
(19 more)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
 29 P77615 (/IMP) P77615 (/IMP) P77615 (/IMP) P77615 (/IMP) P77615 (/IMP) P77615 (/IMP) P77615 (/IMP) P77615 (/IMP) P77615 (/IMP) P77615 (/IMP)
(19 more)
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
 12 Q81KR1 (/ISS) Q81KR1 (/ISS) Q81KR1 (/ISS) Q81KR1 (/ISS) Q81KR1 (/ISS) Q81KR1 (/ISS) Q81KR1 (/ISS) Q81KR1 (/ISS) Q81KR1 (/ISS) Q81KR1 (/ISS)
(2 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 10 A0A0E2J8L1 (/EXP) A0A0E2J8L1 (/EXP) A8AWB2 (/EXP) A8AWB2 (/EXP) N0CDN9 (/EXP) Q18AR8 (/EXP) Q18AR8 (/EXP) Q18AR8 (/EXP) Q18AR8 (/EXP) Q8EBJ8 (/EXP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
 10 P25144 (/IDA) P25144 (/IDA) P25144 (/IDA) P25144 (/IDA) P25144 (/IDA) P25144 (/IDA) P25144 (/IDA) P25144 (/IDA) P25144 (/IDA) P25144 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
 7 Q18AR8 (/EXP) Q18AR8 (/EXP) Q18AR8 (/EXP) Q18AR8 (/EXP) S5RJF3 (/EXP) S5RJF3 (/EXP) S5RJF3 (/EXP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 148 P0ACP7 (/IDA) P0ACP7 (/IDA) P0ACP7 (/IDA) P0ACP7 (/IDA) P0ACP7 (/IDA) P0ACP7 (/IDA) P0ACP7 (/IDA) P0ACP7 (/IDA) P0ACP7 (/IDA) P0ACP7 (/IDA)
(138 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 94 A0A0E2J8L1 (/IDA) A0A0E2J8L1 (/IDA) A8AWB2 (/IDA) A8AWB2 (/IDA) F9UQH6 (/IDA) F9UQH6 (/IDA) F9UQH6 (/IDA) F9UQH6 (/IDA) F9UQH6 (/IDA) F9UQH6 (/IDA)
(84 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 71 A0A0E2J8L1 (/IMP) A0A0E2J8L1 (/IMP) A8AWB2 (/IMP) A8AWB2 (/IMP) F9UQH6 (/IMP) F9UQH6 (/IMP) F9UQH6 (/IMP) F9UQH6 (/IMP) F9UQH6 (/IMP) F9UQH6 (/IMP)
(61 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 35 P03023 (/HDA) P03023 (/HDA) P03023 (/HDA) P03023 (/HDA) P03023 (/HDA) P03023 (/HDA) P03023 (/HDA) P03023 (/HDA) P03023 (/HDA) P03023 (/HDA)
(25 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 30 F9UQH6 (/IPI) F9UQH6 (/IPI) F9UQH6 (/IPI) F9UQH6 (/IPI) F9UQH6 (/IPI) F9UQH6 (/IPI) P25144 (/IPI) P25144 (/IPI) P25144 (/IPI) P25144 (/IPI)
(20 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 3 Q9A3Y5 (/EXP) Q9A3Y5 (/EXP) Q9A3Y5 (/EXP)